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7 papers found.
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Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients

Background Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the central nervous system with different pathogenesis, brain lesion patterns, and treatment strategies. However, it is still difficult to distinguish these two disease entities by neuroimaging studies. Herein, we attempt to differentiate NMOSD from MS by comparing...

High frequency of SPG4 in Taiwanese families with autosomal dominant hereditary spastic paraplegia

Hung-Chou Kuo 5 6 Yih-Ru Wu 5 6 Rong-Kuo Lyu 5 6 Jen-Wen Hung 4 Ying-Chao Chang 7 Chin-Song Lu 0 1 6 8 0 Neuroscience Research Center, Chang Gung Memorial Hospital , Linkou, Taoyuan , Taiwan 1 Section of

Clinical Correlations of Motor and Somatosensory Evoked Potentials in Neuromyelitis Optica

Background Motor and somatosensory evoked potentials (MEPs and SSEPs) are sensitive tools for detecting subclinical lesions, assessing disease severity, and determining the prognosis for outcomes of patients with inflammatory neurological diseases such as multiple sclerosis. However, their roles in neuromyelitis optica (NMO), a severe inflammatory neurological disease that...

SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population

Essential tremor (ET), which is one of the most common movement disorders, may lead to severe interference in quality of life. The first genome-wide association study (GWAS) has identified an association of the LINGO1 variant (rs9652490) with ET in Americans and Europeans. Recently, a second GWAS that was performed in a European population has discovered a new variant (rs3794087...

Painful ophthalmoplegia with normal cranial imaging

Background Painful ophthalmoplegia with normal cranial imaging is rare and confined to limited etiologies. In this study, we aimed to elucidate these causes by evaluating clinical presentations and treatment responses. Methods Cases of painful ophthalmoplegia with normal cranial MRI at a single center between January 2001 and June 2011 were retrospectively reviewed. Diagnoses of...

Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome

Background The underlying change of gene network expression of Guillain-Barré syndrome (GBS) remains elusive. We sought to identify GBS-associated gene networks and signaling pathways by analyzing the transcriptional profile of leukocytes in the patients with GBS. Methods and Findings Quantitative global gene expression microarray analysis of peripheral blood leukocytes was...

Validation of a Chinese version of disease specific quality of life scale (HFS-36) for hemifacial spasm in Taiwan

Background and object There was no Chinese questionnaire to evaluate the health-related quality of life (HRQoL) in patients with hemifacial spasm (HFS). In this study, we aimed to validate a new disease-specific HRQoL scale for HFS (HFS-36) in Chinese version, and compared it to SF-36, a generic HRQoL scale. Patients and Methods The HFS-36 Chinese version was modified from...