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IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

, TaiwanWei-Yu Chen, Jenq-Lin Yang, Lung-Chih Li, Ru-Fang Li, Ya-Ting Chang, Lo-Hsin Dai & Wan-Chen WangInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanYi-Hsiu Wu & Ya-Jen ChangDivision of ... Lung-Chih Li in:Nature Research journals • PubMed • Google Scholar Search for Ru-Fang Li in:Nature Research journals • PubMed • Google Scholar Search for Ya-Ting Chang in:Nature Research journals

Poincaré Inequalities for Composition Operators with Norm

; Published 1 April 2014 Academic Editor: Shusen Ding Copyright © 2014 Ru Fang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Miltefosine Suppresses Hepatic Steatosis by Activating AMPK Signal Pathway

Background and Purpose It has been accepted that AMPK (Adenosine monophosphate–activated protein kinase) activation exhibits many beneficial effects on glucolipid metabolism. Lysophosphatidylcholine (LPC) is an important lysophospholipid which can improve blood glucose levels in diabetic mice and attenuate inflammation by activating AMPK signal pathway in macrophages. Synthetic...

Nr2f1b control venous specification and angiogenic patterning during zebrafish vascular development

Background The specification of vein and the patterning of intersegmental vessels (ISV) controlled by transcription factor is not fully characterized. The orphan nuclear receptor Chicken ovalbumin upstream promoter transcription factor II (CoupTFII, a.k.a NR2F2) positively regulates vein identity in mice. In this study, we show that nr2f1b is important for vein and tip cell...

Singular integrals of the compositions of Laplace-Beltrami and Green's operators

We establish the Poincaré-type inequalities for the composition of the Laplace-Beltrami operator and the Green's operator applied to the solutions of the non-homogeneous A-harmonic equation in the John domain. We also obtain some estimates for the integrals of the composite operator with a singular density.

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays

Background Alternative splicing of exons in a pre-mRNA transcript is an important mechanism which contributes to protein diversity in human. Arrays for detecting alternative splicing are available using several different probe designs, including those based on exon-junctions. In this work, we introduce a new method for predicting alternatively skipped exons from exon-junction...

Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming

Pluripotent stem cells are derived from culture of early embryos or the germline and can be induced by reprogramming of somatic cells. Barriers to reprogramming that stabilize the differentiated state and have tumor suppression functions are expected to exist. However, we have a limited understanding of what such barriers might be. To find novel barriers to reprogramming to...

Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation

Major depressive disorder is a common neuropsychiatric disorder contributing to several socio-economic burdens including disability and suicide. As the underlying pathophysiology of major depressive disorder remains unclear, no objective test is yet available for aiding diagnosis or monitoring disease progression. To contribute to a better understanding of its pathogenesis, a...

Genetic and Cytological Analysis of a Novel Type of Low Temperature-Dependent Intrasubspecific Hybrid Weakness in Rice

Hybrid weakness (HW) is an important postzygotic isolation which occurs in both intra- and inter-specific crosses. In this study, we described a novel low temperature-dependent intrasubspecific hybrid weakness in the F1 plants derived from the cross between two indica rice varieties Taifeng A and V1134. HW plants showed growth retardation, reduced panicle number and pale green...

Phenotypic Differentiation Is Associated with Gender Plasticity and Its Responsive Delay to Environmental Changes in Alternanthera philoxeroides – Phenotypic Differentiation in Alligator Weed

Phenotypic plasticity is common in many taxa, and it may increase an organism's fitness in heterogeneous environments. However, in some cases, the frequency of environmental changes can be faster than the ability of the individual to produce new adaptive phenotypes. The importance of such a time delay in terms of individual fitness and species adaptability has not been well...

A multi-array multi-SNP genotyping algorithm for Affymetrix SNP microarrays

Motivation: Modern strategies for mapping disease loci require efficient genotyping of a large number of known polymorphic sites in the genome. The sensitive and high-throughput nature of hybridization-based DNA microarray technology provides an ideal platform for such an application by interrogating up to hundreds of thousands of single nucleotide polymorphisms (SNPs) in a...

Validity of the 32-item Hypomania Checklist (HCL-32) in a clinical sample with mood disorders in China

Background The 32-item Hypomania Checklist (HCL-32), a questionnaire for screening bipolar disorders, has been utilised in several countries, but it unclear if the Chinese version of the HCL-32 is valid. Methods Consecutive patients with bipolar disorders (BP, N = 300) and unipolar major depression (UP, N = 156) completed the Chinese version of the HCL-32. The subjects underwent...

CompMoby: Comparative MobyDick for detection of cis-regulatory motifs

Background The regulation of gene expression is complex and occurs at many levels, including transcriptional and post-transcriptional, in metazoans. Transcriptional regulation is mainly determined by sequence elements within the promoter regions of genes while sequence elements within the 3' untranslated regions of mRNAs play important roles in post-transcriptional regulation...

Evaluation of Mood Disorder Questionnaire (MDQ) in Patients with Mood Disorders: A Multicenter Trial across China

Background The aim of this study was to test the ability of the Chinese version of the Mood Disorder Questionnaire (MDQ) to identify Bipolar Disorders (BD) in patients diagnosed with Major Depressive Disorder (MDD) or Unipolar Disorder (UD) in the clinical setting. Methods 1,487 being treated for MDD or UD at 12 mental health centers across China, completed the MDQ and...

Molecular Biomarker Analyses Using Circulating Tumor Cells

Background Evaluation of cancer biomarkers from blood could significantly enable biomarker assessment by providing a relatively non-invasive source of representative tumor material. Circulating Tumor Cells (CTCs) isolated from blood of metastatic cancer patients hold significant promise in this regard. Methodology/Principal Findings Using spiked tumor-cells we evaluated CTC...

SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system

SNPLogic (http://www.snplogic.org) brings together single nucleotide polymorphism (SNP) information from numerous sources to provide a comprehensive SNP selection, annotation and prioritization system for design and analysis of genotyping projects. SNPLogic integrates information about the genetic context of SNPs (gene, chromosomal region, functional location, haplotypes tags and...

Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions

Background Epigenetics is the study of heritable changes in gene function that cannot be explained by changes in DNA sequence. One of the most commonly studied epigenetic alterations is cytosine methylation, which is a well recognized mechanism of epigenetic gene silencing and often occurs at tumor suppressor gene loci in human cancer. Arrays are now being used to study DNA...

Severe Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Sialic Acid-Binding Immunoglobulin-Like Lectin-6 and Pappalysin-2

Preeclampsia (PE), which affects 4–8% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. Within the basal plate, placental cytotrophoblasts (CTBs) of fetal origin invade the uterus and extensively remodel the maternal vasculature. In PE, CTB invasion is often shallow, and vascular remodeling is rudimentary. To better understand possible causes...

Demographic and Clinical Features and Prescribing Patterns of Psychotropic Medications in Patients with the Melancholic Subtype of Major Depressive Disorder in China

China Yu-Tao Xiang Gang Wang Chen Hu Tong Guo Gabor S. Ungvari Amy M. Kilbourne . Kelly Y. C. Lai Tian-Mei Si Qi-Wen Zheng Da-Fang Chen Yi-Ru Fang Zheng Lu Hai-Chen Yang Jian Hu Zhi-Yu Chen Yi Huang Jing