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A nested case-control study of 277 prediagnostic serum cytokines and glioma

Recent research shows bidirectional communication between the normal brain and the peripheral immune system. Glioma is a primary brain tumor characterized by systemic immunosuppression. To better understand gliomagenesis, we evaluated associations between 277 prediagnostic serum cytokines and glioma. We used glioma (n = 487) and matched control (n = 487) specimens from the Janus...

Deciphering Asthma Biomarkers with Protein Profiling Technology

Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and...

Deciphering Asthma Biomarkers with Protein Profiling Technology

Asthma is a chronic inflammatory disease of the airways, resulting in bronchial hyperresponsiveness with every allergen exposure. It is now clear that asthma is not a single disease, but rather a multifaceted syndrome that results from a variety of biologic mechanisms. Asthma is further problematic given that the disease consists of many variants, each with its own etiologic and...

Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma

manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. Competing Interests: Ruo-Pan Huang and Brett Burkholder are employed by RayBiotech, Inc. and Adam ... -Pan Huang, Brett Burkholder; Buckeye Psychiatry: Adam Brandemihl), but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the

Identification of Five Serum Protein Markers for Detection of Ovarian Cancer by Antibody Arrays

BackgroundProtein and antibody arrays have emerged as a promising technology to study protein expression and protein function in a high-throughput manner. These arrays also represent a new opportunity to profile protein expression levels in cancer patients’ samples and to identify useful biosignatures for clinical diagnosis, disease classification, prediction, drug development...

Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain

Vardarajan 8 Ruo-Pan Huang 6 7 Elizabeth D. Kirby 0 Rachelle Abbey 0 Bradley F. Boeve 5 Adam L. Boxer 10 Lindsay A. Farrer 8 9 NiCole Finch 4 Neill R. Graff-Radford Elizabeth Head Matan Hofree Ruochun Huang 6

Development of IGF Signaling Antibody Arrays for the Identification of Hepatocellular Carcinoma Biomarkers

Zhong-Sheng Wang 0 Ruo-Pan Huang 0 Bin He, Baylor College of Medicine, United States of America 0 1 Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University , Guangzhou ... , decision to publish, or preparation of the manuscript. Competing Interests: Ying-Qing Mao, Wei-Dong Jiang, Yun-Ru Chen, Zhi Shi, Yan-Li Liu and Ruo-Pan Huang are the employees of RayBiotech, Inc. This does

Tumor promotion by hydrogen peroxide in rat liver epithelial cells

Reactive oxygen species, including H2O2, play an important role in the tumor promotion process. Using an in vitro model of tumor promotion involving the rat liver epithelial oval cell line T51B, the tumor promoting activity of H2O2 in N-methyl-N′-nitro-N-nitrosoguanidine-initiated cells was studied. In this assay system, the promoting effect of H2O2 is evidenced by the formation...