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Single-molecule characterization of extrinsic transcription termination by Sen1 helicase

Extrinsic transcription termination typically involves remodeling of RNA polymerase by an accessory helicase. In yeast this is accomplished by the Sen1 helicase homologous to human senataxin (SETX). To gain insight into these processes we develop a DNA scaffold construct compatible with magnetic-trapping assays and from which S. cerevisiae RNA polymerase II (Pol II), as well as E...

Evaluation of blood culture epidemiology and efficiency in a large European teaching hospital

Author Contributions Conceptualization: T. A. M. Hekker, N. Alam, P. W. B. Nanayakkara. Data curation: R. S. Nannan Panday, S. Wang, T. A. M. Hekker. Formal analysis: P. M. van de Ven. Investigation: R ... . S. Nannan Panday, S. Wang. Methodology: R. S. Nannan Panday, S. Wang, P. W. B. Nanayakkara. Project administration: R. S. Nannan Panday. Resources: P. W. B. Nanayakkara. Supervision: P. W. B

Abnormality of visual neuromagnetic activation in female migraineurs without aura between attacks

affiliations Zhi Y. ZhouYan W. YuDi WuHong X. LiuJing XiangTing WuQi Q. ChenXiao SWang Open Access Research article First Online: 16 January 2019 219 Downloads Abstract Objective The present

On the Reliability of Accelerated Testing in AIGaAs/InGaAs/GaAs PHEMTs

Active and Passive Elec. Comp. 0882-7516 ON THE RELIABILITY OF ACCELERATED TESTING IN AlGaAs=InGaAs=GaAs PHEMTs K. F. YARN 1 W. C. CHIEN 1 C. S. WANG 0 0 National Cheng Kung University, Department

The influence of Arctic amplification on mid-latitude summer circulation

). ADSArticle Google Scholar38. Schubert, S., Wang, H. & Suarez, M. Warm season subseasonal variability and climate extremes in the Northern Hemisphere: The role of stationary Rossby waves. J. Clim. 24, 4773–4792 ... . Res. Lett. 44, 9938–9946 (2017). 129. Bandyopadhyay, S., Kanji, S. & Wang, L. The impact of rainfall and temperature variation on diarrheal prevalence in Sub-Saharan Africa. Appl. Geogr. 33, 63–72 (2012

An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells

human cells Ling-Ling Chang†1Email author, Wan-Song Alfred Wun2 and Paulus SWang†3, 4, 5, 6 †Contributed equally BMC Pharmacology and Toxicology201819:45 https://doi.org/10.1186/s40360-018-0235 ... syndrome, especially ENDR-induced Cushing’s syndrome. Notes Ling-Ling Chang and Paulus S. Wang contributed equally to this work. Abbreviations 11β-HSD1:  11β-hydroxysteroid dehydrogenase I BPA

Chronic Tenosynovitis due to Mycobacteria kansasii in an Immunocompetent Host

We report a case of a healthy 56-year-old male who presented with chronic swelling and erythema in his right hand. He had a prior chemical exposure several years ago and subsequent exposure to freshwater, fish tank, and soil. Laboratory data showed a slightly elevated CRP. An MRI was consistent with suggestive of flexor tenosynovitis. He underwent surgical debridement and was...

Chronic Tenosynovitis due to Mycobacteria kansasii in an Immunocompetent Host

, USA 4Infection Prevention, Lakeland Health, St. Joseph, MI, USA 5Department of Pathology, Lakeland Health, St. Joseph, MI, USA Correspondence should be addressed to Michael S. Wang; gro.cmws@gnawm ... Received 25 January 2018; Accepted 29 March 2018; Published 16 April 2018 Academic Editor: Larry M. Bush Copyright © 2018 Michael S. Wang et al. This is an open access article distributed under the

Uncertainty propagation analysis by an extended sparse grid technique

In this paper, an uncertainty propagation analysis method is developed based on an extended sparse grid technique and maximum entropy principle, aiming at improving the solving accuracy of the high-order moments and hence the fitting accuracy of the probability density function (PDF) of the system response. The proposed method incorporates the extended Gauss integration into the...

Characteristics of New-Onset and Chronic Sleep Medication Users Among Older Adults: A Retrospective Study of a US Medigap Plan Population using Propensity Score Matching

BackgroundPrescription sleep medications are often utilized to manage sleep problems among older adults even though these drugs are associated with multiple risks.ObjectiveThe aim was to determine the prevalence and characteristics of new-onset compared to chronic sleep medication users and to examine factors associated with the conversion from new to chronic use. A secondary...

Raman spectroscopic study of photosensitive damage to lysozyme structure sensitized by hypocrellin A

Laser Raman spectroscopy was used to detect the nature of the structural change in lysozyme sensitized by hypocrellin A (HA) at the molecular level. The results indicated that the orderly structure of lysozyme has been damaged by the active oxygen (1O2, O2−· and .OH, etc.) generated by HA, and cause the changes in H-bonds system of the main chain and the side chain of lysozyme.

A generic phase between disordered Weyl semimetal and diffusive metal

Quantum phase transitions of three-dimensional (3D) Weyl semimetals (WSMs) subject to uncorrelated on-site disorder are investigated through quantum conductance calculations and finite-size scaling of localization length. Contrary to previous claims that a direct transition from a WSM to a diffusive metal (DM) occurs, an intermediate phase of Chern insulator (CI) between the two...

Effect of therapeutic interchange on medication reconciliation during hospitalization and upon discharge in a geriatric population

. (DOCX) sectional studies. (DOC) S2 File. Deidentified study dataset. (XLSX) Author Contributions Conceptualization: Jessica S. Wang, Leora I. Horwitz. Data curation: Jessica S. Wang, Leora I. Horwitz ... . Formal analysis: Leora I. Horwitz. Funding acquisition: Leora I. Horwitz. Investigation: Jessica S. Wang, Robert L. Fogerty, Leora I. Horwitz. Methodology: Jessica S. Wang, Robert L. Fogerty, Leora I

Economic freedom and IPO underpricing

This paper examines how the difference in institutional environments constitutes differential IPO underpricing across countries. Using the Heritage Foundation’s Index of Economic Freedom (IEF) as a proxy for the heterogeneous institutional environment, and a sample of 3728 IPOs from 22 countries and regions over the period 1993–2014, we find that countries with higher economic...

Falls-Related Drug Use and Risk of Falls Among Older Adults: A Study in a US Medicare Population

BackgroundApproximately one-third of community-dwelling older adults fall each year, and approximately 10% have falls requiring medical services. Among other factors, research studies have linked certain medications with an increased risk of falls.ObjectiveThe aim of this study was to examine the risk of falls relative to use patterns among new and continuing falls-related drug...

Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma

L-S Wang 2 J-L Xia 0 0 Department of Oncology, Minhang Hospital, Fudan University , Shanghai , China 1 Department of Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander-University