Advanced search    

Search: authors:"Sabrina Prudente"

14 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation

, Jacques Mercier, Ramon Gomis, Serghey Litvinov, Elza Khusnutdinova, Catalina Poiana, Renato Pasquali, Davide Lauro, Giorgio Sesti, Sabrina Prudente, Vincenzo Trischitta, Agathocles Tsatsoulis, Agron Ylli

Identification and Clinical Characterization of Adult Patients with Multigenerational Diabetes Mellitus

could be send to: Sabrina Prudente, PhD or Vincenzo Trischitta, MD CSS-Mendel Institute Viale Regina Margherita 261 00198 Rome Italy. E- mail adress: 2 Editor: Victor Sanchez-Margalet, Virgen Macarena

GALNT2 Expression Is Reduced in Patients with Type 2 Diabetes: Possible Role of Hyperglycemia

Impaired insulin action plays a major role in the pathogenesis of type 2 diabetes, a chronic metabolic disorder which imposes a tremendous burden to morbidity and mortality worldwide. Unraveling the molecular mechanisms underlying insulin resistance would improve setting up preventive and treatment strategies of type 2 diabetes. Down-regulation of GALNT2, an UDPN-acetyl-alpha-D...

PPARγ2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case–control studies

Background. Insulin resistance has a role in diabetic nephropathy. The A12 variant of the PPARγ2 P121A polymorphism has been firmly associated with reduced risk of insulin resistance, while its role on the risk of albuminuria in patients with type 2 diabetes is uncertain. This study investigated whether the PPARγ2 P12A polymorphism modulates the risk of albuminuria in these...

The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus

Background We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM).

Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes

Background High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes...

Role of the ENPP1 K121Q Polymorphism in Glucose Homeostasis

Roberto Baratta Paola Rossetti Sabrina Prudente Fabrizio Barbetti Dora Sudano Angela Nigro Maria Grazia Farina Fabio Pellegrini Vincenzo Trischitta Lucia Frittitta OBJECTIVETo study the role of the

ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies

The aim of this study was to deeper investigate the mechanisms through which ENPP1, a negative modulator of insulin receptor (IR) activation, plays a role on insulin signaling, insulin secretion and eventually glucose metabolism. ENPP1 cDNA (carrying either K121 or Q121 variant) was transfected in HepG2 liver-, L6 skeletal muscle- and INS1E beta-cells. Insulin-induced IR...

Impact of the PPAR-γ2 Pro12Ala Polymorphism and ACE Inhibitor Therapy on New-Onset Microalbuminuria in Type 2 Diabetes: Evidence From BENEDICT

Salvatore De Cosmo Nicola Motterlini Sabrina Prudente Fabio Pellegrini Roberto Trevisan Antonio Bossi Giuseppe Remuzzi Vincenzo Trischitta Piero Ruggenenti on behalf of the BENEDICT Study Group

The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European Populations: Evidence From an Updated Meta-Analysis in 42,042 Subjects

Jarred B. McAteer Sabrina Prudente Simonetta Bacci Helen N. Lyon Joel N. Hirschhorn Vincenzo Trischitta Jose C. Florez for the ENPP Consortium OBJECTIVE-Functional studies suggest that the

A Functional Variant of the Adipocyte Glycerol Channel Aquaporin 7 Gene Is Associated With Obesity and Related Metabolic Abnormalities

Sabrina Prudente Elisabetta Flex Eleonora Morini Federica Turchi Daria Capponi Salvatore De Cosmo Vittorio Tassi Valentina Guida Angelo Avogaro Franco Folli Francesca Maiani Lucia Frittitta Bruno

The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy

Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2 diabetes. TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance. We here report that the prevalent...

The ENPP1 Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals: Evidence for Interaction With Obesity in Diabetic Patients

Simonetta Bacci Stefano Rizza Sabrina Prudente Belinda Spoto Christine Powers Antonio Facciorusso Antonio Pacilli Davide Lauro Alessandra Testa Yuan-Yuan Zhang Giuseppe Di Stolfo Francesca Mallamaci

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control subjects (n = 638), type 2 diabetic patients without CAD (n = 535), and type 2 diabetic patients with...