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Search: authors:"Sang Jin Kim"

18 papers found.
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Peripheral Reticular Pigmentary Degeneration and Choroidal Vascular Insufficiency, Studied by Ultra Wide-Field Fluorescein Angiography

Purpose To explore the pathogenesis of peripheral reticular pigmentary degeneration (PRPD) and its clinical significance. Methods This cross-sectional, observational study (conducted between January 2010 and May 2015) enrolled 441 eyes of 229 subjects, including 35 eyes with PRPD and 406 eyes without PRPD, which was identified by ultra-wide-field fluorescein angiography (UWFA...

Evaluating the efficacy of switching from lamivudine plus adefovir to tenofovir disoproxil fumarate monotherapy in lamivudine-resistant stable hepatitis B patients

/ 12 Author Contributions Conceptualization: Byoung Kuk Jang. Data curation: Heon Ju Lee, Sang Jin Kim, Young Oh Kweon, Soo Young Park, Jeong Heo, Hyun Young Woo, Jae Seok Hwang, Woo Jin Chung, Chang ... Hyeong Lee, Byung Seok Kim, Jeong Ill Suh, Won Young Tak, Byoung Kuk Jang. Formal analysis: Heon Ju Lee, Sang Jin Kim, Byoung Kuk Jang. Funding acquisition: Byoung Kuk Jang. Investigation: Heon Ju Lee

Complete genome sequence of Novosphingobium pentaromativorans US6-1T

Novosphingobium pentaromativorans US6-1T is a species in the family Sphingomonadaceae. According to the phylogenetic analysis based on 16S rRNA gene sequence of the N. pentaromativorans US6-1T and nine genome-sequenced strains in the genus Novosphingobium, the similarity ranged from 93.9 to 99.9 % and the highest similarity was found with Novosphingobium sp. PP1Y (99.9...

Morphologic Characteristics of Choroid in the Major Choroidal Thickening Diseases, Studied by Optical Coherence Tomography

We investigated morphologic features of choroid in the choroidal thickening diseases, including central serous chorioretinopathy (CSC), polypoidal choroidal vasculopathy (PCV), and Vogt-Koyanagi-Harada disease (VKH), by a novel tomographic classification system of the choroid. This cross-sectional study involved 30 patients with active CSC, 30 patients with active PCV, and 27...

Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings

Purpose The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). Methods This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched...

Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana

Background Vesicle fusion is an essential process for maintaining the structure and function of the endomembrane system. Fusion is mediated by t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) fusion proteins on the target membrane and v-SNAREs on the vesicle membrane; v-and t-SNAREs interact with each other, driving vesicle fusion with the target...

Tat-DJ-1 inhibits oxidative stress-mediated RINm5F cell death through suppression of NF-κB and MAPK activation

Oxidative stress is highly involved in the development of diabetes mellitus by destruction of pancreatic β-cells. DJ-1 is an antioxidant protein and DJ-1 expression levels are known to be reduced in diabetes mellitus. Thus, we examined the effects of DJ-1 protein against oxidative stress-induced pancreatic β-cell (RINm5F) death using cell permeable wild-type and mutant-type...

Surface-Engineered Graphene Quantum Dots Incorporated into Polymer Layers for High Performance Organic Photovoltaics

), Republic of Korea. Author information Author notesJung Kyu Kim & Sang Jin Kim These authors contributed equally to this work. AffiliationsDepartment of Mechanical Engineering, Stanford University ... KoreaJung Kyu Kim & Jong Hyeok Park AuthorsSearch for Jung Kyu Kim in:Nature Research journals • PubMed • Google ScholarSearch for Sang Jin Kim in:Nature Research journals • PubMed • Google ScholarSearch for

Origin of White Electroluminescence in Graphene Quantum Dots Embedded Host/Guest Polymer Light Emitting Diodes

, Seoul University, Seoul 151-747, Republic of KoreaMyung Jin Park, Sang Jin Kim & Byung Hee HongAdvanced Photonics Research Institute (APRI), Gwangju Institute of Science and Technology (GIST), Gwangju 500 ... in:Nature Research journals • PubMed • Google ScholarSearch for Myung Jin Park in:Nature Research journals • PubMed • Google ScholarSearch for Sang Jin Kim in:Nature Research journals • PubMed • Google

Targeted resequencing of candidate genes reveals novel variants associated with severe Behçet’s uveitis

Behçet’s disease (BD) is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent uveitis, oral and genital ulcers and skin lesions. To identify some pathogenic variants associated with severe Behçet’s uveitis, we used targeted and massively parallel sequencing methods to explore the genetic diversity of target regions. A solution-based...

Efficacy and Safety of Lobeglitazone Monotherapy in Patients with Type 2 Diabetes Mellitus over 24-Weeks: A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo Controlled Trial

Sang Jin Kim 0 Dong Seop Choi 0 Guoying Wang, Johns Hopkins Bloomberg School of Public Health, United States of America 0 1 Department of Internal Medicine, Korea University Anam Hospital , Seoul

Overexpression of Arabidopsis Sorting Nexin AtSNX2b Inhibits Endocytic Trafficking to the Vacuole

Sorting nexins are conserved proteins that function in vesicular trafficking and contain a characteristic phox homology (PX) domain. Here, we characterize the ubiquitously expressed Arabidopsis thaliana sorting nexin AtSNX2b. Sub-cellular fractionation studies indicate that AtSNX2b is peripherally associated with membranes. The AtSNX2b PX domain binds to phosphatidylinositol 3...

Proteomic Characterization of Plasmid pLA1 for Biodegradation of Polycyclic Aromatic Hydrocarbons in the Marine Bacterium, Novosphingobium pentaromativorans US6-1

Novosphingobium pentaromativorans US6-1 is a halophilic marine bacterium able to degrade polycyclic aromatic hydrocarbons (PAHs). Genome sequence analysis revealed that the large plasmid pLA1 present in N. pentaromativorans US6-1 consists of 199 ORFs and possess putative biodegradation genes that may be involved in PAH degradation. 1-DE/LC-MS/MS analysis of N. pentaromativorans...

Active control of all-fibre graphene devices with electrical gating

ScholarSearch for Sukang Bae in:Nature Research journals • PubMed • Google ScholarSearch for Sang Jin Kim in:Nature Research journals • PubMed • Google ScholarSearch for Kwanil Lee in:Nature Research journals

Stanniocalcin-1 Protects Retinal Ganglion Cells by Inhibiting Apoptosis and Oxidative Damage

Optic neuropathy including glaucoma is one of the leading causes of irreversible vision loss, and there are currently no effective therapies. The hallmark of pathophysiology of optic neuropathy is oxidative stress and apoptotic death of retinal ganglion cells (RGCs), a population of neurons in the central nervous system with their soma in the inner retina and axons in the optic...

Novel Lipolytic Enzymes Identified from Metagenomic Library of Deep-Sea Sediment

Metagenomic library was constructed from a deep-sea sediment sample and screened for lipolytic activity. Open-reading frames of six positive clones showed only 33–58% amino acid identities to the known proteins. One of them was assigned to a new group while others were grouped into Families I and V or EstD Family. By employing a combination of approaches such as removing the...

Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study

Despite the clinical impact of non-motor symptoms (NMS) in Parkinson’s disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into...

Mutations at codons 178, 200-129, and 232 contributed to the inherited prion diseases in Korean patients

Background Polymorphisms of the human prion protein gene (PRNP) contribute to the genetic determinants of Creutzfeldt-Jakob disease (CJD). Numerous polymorphisms in the promoter regions as well as the open reading frame of PRNP were investigated. Greater than 90% of Korean, Chinese, and Japanese carry the homozygote 129 MM codon. In Korea, polymorphisms have not been...