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Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers

, Department of Transfusion Medicine, Clinical Center; National Institutes of Health, Bethesda, Maryland, USAShutong Liu, Ping Jin, Sara Civini, Jiaqiang Ren & David F. StroncekSkeletal Biology Section, National ... ScholarSearch for Sara Civini in:Nature Research journals • PubMed • Google ScholarSearch for Jiaqiang Ren in:Nature Research journals • PubMed • Google ScholarSearch for Jo-Anna Reems in:Nature Research journals

Leukemia cells induce changes in human bone marrow stromal cells

Background Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metastasis. BMSCs secrete of a wide range of cytokines, growth factors and matrix proteins which contribute to the pro-tumorigenic marrow microenvironment. The...

Leukemia cells induce changes in human bone marrow stromal cells

Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metastasis. BMSCs secrete of a wide range of cytokines, growth factors and matrix proteins which contribute to the pro-tumorigenic marrow microenvironment. The inflammatory...

Comparison of endometrial regenerative cells and bone marrow stromal cells

Background Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared. Methods We compared micro RNA (miRNA) and gene expression profiles, soluble cytokine and growth factor levels and ability to inhibit ongoing mixed leukocyte...

Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting

David F Stroncek 0 Cornelis JM Melief Luciano Castiello 0 Alessandra Cesano Martin A Cheever Sara Civini 0 Begonya Comin-Anduix Thomas F Gajewski Philip D Greenberg Pawel Kalinski Howard L Kaufman