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Perceived discrimination, health and wellbeing among middle-aged and older lesbian, gay and bisexual people: A prospective study

wellbeing outcomes. (DOCX) Author Contributions Conceptualization: Sarah E. Jackson, Ruth A. Hackett. Formal analysis: Sarah E. Jackson. Funding acquisition: Sarah E. Jackson, Andrew Steptoe ... . Investigation: Sarah E. Jackson. Methodology: Sarah E. Jackson, Andrew Steptoe. Supervision: Andrew Steptoe. Writing ? original draft: Sarah E. Jackson. Writing ? review & editing: Ruth A. Hackett, Igor

Generation, maintenance and tissue distribution of T cell responses to human cytomegalovirus in lytic and latent infection

Understanding how the T cell memory response directed towards human cytomegalovirus (HCMV) develops and changes over time while the virus persists is important. Whilst HCMV primary infection and periodic reactivation is well controlled by T cell responses in healthy people, when the immune system is compromised such as post-transplantation, during pregnancy, or underdeveloped...

Weight Loss and Mortality in Overweight and Obese Cancer Survivors: A Systematic Review

Background Excess adiposity is a risk factor for poorer cancer survival, but there is uncertainty over whether losing weight reduces the risk. We conducted a critical review of the literature examining weight loss and mortality in overweight or obese cancer survivors. Methods We systematically searched PubMed and EMBASE for articles reporting associations between weight loss and...

CMV immune evasion and manipulation of the immune system with aging

Human cytomegalovirus (HCMV) encodes numerous proteins and microRNAs that function to evade the immune response and allow the virus to replicate and disseminate in the face of a competent innate and acquired immune system. The establishment of a latent infection by CMV, which if completely quiescent at the level of viral gene expression would represent an ultimate in immune...

The impact of a cancer diagnosis on weight change: findings from prospective, population-based cohorts in the UK and the US

Background Obesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts of older adults, we examined weight change in cancer survivors and cancer-free controls in relation to baseline weight status. Methods In the English...

Psychological Changes following Weight Loss in Overweight and Obese Adults: A Prospective Cohort Study

Background Participation in weight loss programs is often associated with improved wellbeing alongside reduced cardio-metabolic risk. In contrast, population-based analyses have found no evidence of psychological benefits of weight loss, but this may be due to inclusion of healthy-weight individuals. We therefore examined cardio-metabolic and psychological changes following...