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Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models

Satoshi Abe contributed equally to this work. Chinese hamster ovary (CHO), A9, and DT40 cells are mainly used as donor cells in MMCT (Fig. 1a) because they are capable of micronucleation with elongated

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9

Tottori prefecture. Author Contributions Conceptualization: Yasuhiro Kazuki. Data curation: Kazuhisa Honma, Satoshi Abe. Formal analysis: Kazuhisa Honma, Satoshi Abe. Funding acquisition: Mitsuo ... Oshimura, Yasuhiro Kazuki. 17 / 19 Investigation: Kazuhisa Honma. Methodology: Kazuhisa Honma, Satoshi Abe, Takeshi Endo, Narumi Uno. Project administration: Satoshi Abe. Resources: Tetsuya Ohbayashi

Observation of gold sub-nanocluster nucleation within a crystalline protein cage

, Satoshi Abe & Takafumi Ueno AuthorsSearch for Basudev Maity in:Nature Research journals • PubMed • Google ScholarSearch for Satoshi Abe in:Nature Research journals • PubMed • Google ScholarSearch for

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies

external funding received for this study. This research was partly performed at Tottori Bio Frontier managed by Tottori prefecture. Author Contributions Conceptualization: Satoshi Abe, Mitsuo Oshimura ... , Yasuhiro Kazuki. Data curation: Daisuke Satoh, Satoru Iwado, Satoshi Abe, Shinobu Wakuri, Mitsuo Oshimura, Yasuhiro Kazuki. Formal analysis: Daisuke Satoh, Satoru Iwado, Satoshi Abe, Shinobu Wakuri, Mitsuo

Effective prevention of sorafenib-induced hand–foot syndrome by dried-bonito broth

Effective prevention of sorafenib-induced hand-foot syndrome by dried-bonito broth Kenya Kamimura,1 Yoko Shinagawa-Kobayashi,1 Ryo Goto,1 Kohei Ogawa,1 Takeshi Yokoo,1 Akira Sakamaki,1 Satoshi Abe,1

Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient

A 56-year-old Japanese man with liver cirrhosis (LC) due to hepatitis C virus was admitted to our hospital for radiofrequency ablation of residual tumor following lusutrombopag administration. Laboratory tests revealed thrombocytopenia and leukopenia. The patient’s LC was managed, and he was classified as Child–Pugh A. After admission, lusutrombopag was administered for 7 days...

Long-term efficacy and safety of nalfurafine hydrochloride on pruritus in chronic liver disease patients: Patient-reported outcome based analyses

Background and aim Among various symptoms accompanied with chronic liver disease, pruritus affects the quality of life of patients, causing physical and mental stress, and worsens hepatic function. Recently, κ-opioid receptor agonist, nalfurafine hydrochloride was approved to treat central pruritus in patients with liver disease in Japan. This study aimed to assess the long-term...

Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient

A 56-year-old Japanese man with liver cirrhosis (LC) due to hepatitis C virus was admitted to our hospital for radiofrequency ablation of residual tumor following lusutrombopag administration. Laboratory tests revealed thrombocytopenia and leukopenia. The patient’s LC was managed, and he was classified as Child–Pugh A. After admission, lusutrombopag was administered for 7 days...

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology

, 683-8503, JapanKazuhisa Honma & Yasuhiro Kazuki AuthorsSearch for Satoshi Abe in:Nature Research journals • PubMed • Google Scholar Search for Kaoru Kobayashi in:Nature Research journals • PubMed

Cone-Beam Computed Tomography Correlates with Conventional Helical Computed Tomography in Evaluation of Lipiodol Accumulation in HCC after Chemoembolization

Background & Aims The amount of drug-loaded lipiodol in an HCC tumor post-transarterial chemoembolization (TACE) correlates with the risk of local tumor recurrence. Lipiodol enhancement of a tumor on conventional CT, measured in Hounsfield units (HU), can predict tumor response. Here we investigate whether cone-beam CT (CBCT) can also be used to predict tumor response, providing...

A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells

Telomeric and subtelomeric regions of human chromosomes largely consist of highly repetitive and redundant DNA sequences, resulting in a paucity of unique DNA sequences specific to individual telomeres. Accordingly, it is difficult to analyze telomere metabolism on a single-telomere basis. To circumvent this problem, we have exploited a human artificial chromosome (HAC#21...

Study on the Dependence of Reverse Simulation for Identifying a Pollutant Source on Grid Resolution and Filter Width in Cavity Flow

2 March 2012; Accepted 3 March 2012 Academic Editor: Fu-Yun Zhao Copyright © 2012 Satoshi Abe et al. This is an open access article distributed under the Creative Commons Attribution License

Study on the Dependence of Reverse Simulation for Identifying a Pollutant Source on Grid Resolution and Filter Width in Cavity Flow

2 March 2012; Accepted 3 March 2012 Academic Editor: Fu-Yun Zhao Copyright © 2012 Satoshi Abe et al. This is an open access article distributed under the Creative Commons Attribution License

Predictive Factor of Local Recurrence after Balloon-Occluded TACE with Miriplatin (MPT) in Hepatocellular Carcinoma

Background Miriplatin (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). However, rapid washout has been reported in some cases. Therefore, various methods of administration with MPT have been attempted to increase its therapeutic efficacy. One hopeful method is balloon-occluded TACE (B-TACE), but the therapeutic...

Impact of Sleep-Disordered Breathing on Heart Rate Turbulence in Heart Failure Patients

Background Sleep-disordered breathing (SDB) is associated with adverse outcomes in patients with chronic heart failure (CHF). Additionally, heart rate turbulence (HRT) reflects changes in the sinus cycle length of baroreceptor in response to hemodynamic fluctuations after ventricular premature beat. Recent studies have suggested that HRT as a marker of vagal activity has a...

Liver Dysfunction Assessed by Model for End-Stage Liver Disease Excluding INR (MELD-XI) Scoring System Predicts Adverse Prognosis in Heart Failure

Aims Liver dysfunction due to heart failure (HF) is often referred to as cardiac or congestive hepatopathy. The composite Model for End-Stage Liver Disease excluding INR (MELD-XI) is a robust scoring system of liver function, and a high score is associated with poor prognosis in advanced HF patients with a heart transplantation and/or ventricular assist device. However, the...

Technical approach to individualized respiratory-gated carbon-ion therapy for mobile organs

We propose a strategy of individualized image acquisitions and treatment planning for respiratory-gated carbon-ion therapy. We implemented it in clinical treatments for diseases of mobile organs such as lung cancers at the Gunma University Heavy Ion Medical Center in June 2010. Gated computed tomography (CT) scans were used for treatment planning, and four-dimensional (4D) CT...

Localization of an hTERTrepressor region on human chromosome 3p21.3 using chromosome engineering

Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA. The reactivation of telomerase activity by aberrant upregulation/expression of its catalytic subunit hTERT is a major pathway in human tumorigenesis. However, regulatory mechanisms that control hTERT expression are largely unknown. Previously, we and others have demonstrated that the introduction of human...

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

Human CYP3A is the most abundant P450 isozyme present in the human liver and small intestine, and metabolizes around 50% of medical drugs on the market. The human CYP3A subfamily comprises four members (CYP3A4, CYP3A5, CYP3A7, CYP3A43) encoded on human chromosome 7. However, transgenic mouse lines carrying the entire human CYP3A cluster have not been constructed because of...

Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance

Although particular chromosomal syndromes are phenotypically and clinically distinct, the majority of individuals with autosomal imbalance, such as aneuploidy, manifest mental retardation. A common abnormal phenotype of Down syndrome (DS), the most prevalent autosomal aneuploidy, shows a reduction in both the number and the density of neurons in the brain. As a DS model, we have...