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14 papers found.
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First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors

: Toshihiko Doi, Kohei Shitara, Hideaki Takahashi, Kiyotaka Yoh, Makoto Ueno, Satoshi Kobayashi, Manabu Morimoto, Takuji Okusaka, Hideki Ueno, Chigusa Morizane, Naohiro Okano, Fumio Nagashima, Junji Furuse ... . Data collection: Toshihiko Doi, Kohei Shitara, Hideaki Takahashi, Kiyotaka Yoh, Makoto Ueno, Satoshi Kobayashi, Manabu Morimoto, Takuji Okusaka, Hideki Ueno, Chigusa Morizane, Naohiro Okano, Fumio

Evaluation of renal oxygen saturation using photoacoustic imaging for the early prediction of chronic renal function in a model of ischemia-induced acute kidney injury

Matsumoto, Yasunori Iwata, Kotaro Yoshida, Norihide Yoneda, Takahiro Ogi, Azusa Kitao, Kazuto Kozaka, Wataru Koda, Satoshi Kobayashi, Dai Inoue, Norihiko Sakai, Kengo Furuichi, Takashi Wada, Toshifumi Gabata

Pathology and images of radiation-induced hepatitis: a review article

Recent advances in highly conformal radiotherapies greatly extend the indications for radiotherapy of liver tumors. However, because of poor tolerance to hepatic radiation, estimation of the intensity of irradiation of the liver is important, particularly for a cirrhotic liver. Knowledge of radiation-induced hepatitis is important for understanding how to optimize hepatic...

Prediction model for pancreatic cancer risk in the general Japanese population

, Takashi Sasaki, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Chaochen Wang, Takeshi Nishiyama, Takahisa ... . Funding acquisition: Masahiro Nakatochi, Yingsong Lin, Shogo Kikuchi, Keitaro Matsuo. Resources: Hidemi Ito, Kazuo Hara, Hiroshi Ishii, Masato Ozaka, Takashi Sasaki, Naoki Sasahira, Manabu Morimoto, Satoshi

Learning curve constraint cell automaton model for the lean production of CFRP airframe components

A new model is proposed for the lean production of carbon fiber reinforced plastic (CFRP) airframes. Our method improves the production rate by determining the ideal human-capital balance and inventory density on the factory line. The proposed model is derived as a two-step process: First, an analytical solution for the learning rate shift with a human-capital ratio is obtained...

Evaluation of Focal Liver Reaction after Proton Beam Therapy for Hepatocellular Carcinoma Examined Using Gd-EOB-DTPA Enhanced Hepatic Magnetic Resonance Imaging

Background Proton beam therapy (PBT) achieves good local control for hepatocellular carcinoma (HCC), and toxicity tends to be lower than for photon radiotherapy. Focal liver parenchymal damage in radiotherapy is described as the focal liver reaction (FLR); the threshold doses (TDs) for FLR in the background liver have been analyzed in stereotactic ablative body radiotherapy and...

Modified response evaluation criteria in solid tumors is superior to response evaluation criteria in solid tumors for assessment of responses to sorafenib in patients with advanced hepatocellular carcinoma

Background Modified response evaluation criteria in solid tumors (mRECIST) and RECIST are used to assess the effect of treatment with targeted agents for hepatocellular carcinoma (HCC). The aim of this study was to determine which set of criteria is superior in patients with advanced HCC treated with sorafenib. Methods A multicenter retrospective study to assess the tumor...

Hepatitis C Related Chronic Liver Cirrhosis: Feasibility of Texture Analysis of MR Images for Classification of Fibrosis Stage and Necroinflammatory Activity Grade

Purpose To assess the feasibility of texture analysis for classifying fibrosis stage and necroinflammatory activity grade in patients with chronic hepatitis C on T2-weighted (T2W), T1-weighted (T1W) and Gd-EOB-DTPA-enhanced hepatocyte-phase (EOB-HP) imaging. Materials and methods From April 2008 to June 2012, MR images from 123 patients with pathologically proven chronic...

Molecular Robotics: A New Paradigm for Artifacts

, Robotics, Self-organi- zation, Bottom-up Approach, Nano-devices, Grant-in-Aid for Sci- entific Research on Innovative Areas 2 Satoshi Kobayashi: He received the B.E., M.E. and D.E degrees from the University

The short- and long-term outcomes of radical antegrade modular pancreatosplenectomy for adenocarcinoma of the body and tail of the pancreas

Background Radical antegrade modular pancreatosplenectomy (RAMPS) is a relatively new modification of the standard distal pancreatosplenectomy. In this method, dissection proceeds from right-to-left to achieve negative posterior resection margins. However, short-term and long-term outcomes of RAMPS for pancreatic cancer have not yet been clarified. The aim of this study is to...

Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis

To understand the hemodynamics of hepatocellular carcinoma (HCC) is important for the precise imaging diagnosis and treatment, because there is an intense correlation between their hemodynamics and pathophysiology. Angiogenesis such as sinusoidal capillarization and unpaired arteries shows gradual increase during multi-step hepatocarcinogenesis from high-grade dysplastic nodule...

Optimal schedule of adjuvant chemotherapy with S-1 for stage III colon cancer: study protocol for a randomized controlled trial

Background Although, in Western countries, oxaliplatin-based regimens have been established as a gold standard treatment for patients with stage III or high risk stage II colon cancer after curative resection, in Japan fluorouracil-based regimens have been widely accepted and recommended in the guidelines for adjuvant settings in patients with stage III colon cancer. S-1, an oral...

Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces

Hirohiko Ise Satoshi Kobayashi Mitsuaki Goto Takao Sato Masatomo Kawakubo Masafumi Takahashi Uichi Ikeda Toshihiro Akaike The Author 2010. Published by Oxford University Press. All rights reserved