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Search: authors:"Satoshi Nunomura"

5 papers found.
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The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma

Inhaled corticosteroids (ICSs) are used as first-line drugs for asthma, and various novel antiasthma drugs targeting type 2 immune mediators are now under development. However, molecularly targeted drugs are expensive, creating an economic burden on patients. We and others previously found pendrin/SLC26A4 as a downstream molecule of IL-13, a signature type 2 cytokine critical for...

Common marmoset CD117+ hematopoietic cells possess multipotency

Analysis of the hematopoiesis of non-human primates is important to clarify the evolution of primate-specific hematopoiesis and immune regulation. However, the engraftment and development of the primate hematopoietic system are well-documented only in humans and are not clear in non-human primates. Callithrix jacchus (common marmoset, CM) is a New World monkey with a high rate of...

Double expression of CD34 and CD117 on bone marrow progenitors is a hallmark of the development of functional mast cell of Callithrix jacchus (common marmoset)

Mast cells (MCs) are developed from hematopoietic progenitor cells and play an important role in inflammation. Study of the kinetics of development and accumulation of primate MC in vivo is crucial for the control of human inflammatory diseases, as evolution of the immune system is quite rapid and inflammation including MC response is considered to be different between mouse and...

Role of the FcϵRI β-chain ITAM as a signal regulator for mast cell activation with monomeric IgE

The β-chain of the high-affinity receptor for IgE (FcϵRI) plays a crucial role for amplification of the intracellular signaling in mast cells upon FcϵRI cross-linking by IgE•antigen complexes (IgE•Ag). Some monomeric IgE as well as IgE•Ag stimulate FcϵRI-signaling pathways, leading to cell activation, whereas the biological functions of the β-chain in the monomeric IgE-mediated...

CD45 can act as a negative regulator for the transition from early to late CD4+CD8+ thymocytes

The differentiation process from CD4–CD8– double-negative (DN) thymocytes to CD4+CD8+ double-positive (DP) stage is accompanied by vigorous proliferation. The resulting DP cells contain a sizable proportion of large cycling cells, but most DP cells are small resting cells. To explore the molecular mechanisms which regulate cell proliferation of DP thymocytes prior to further...