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Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model

Sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) and its inhibitory protein called phospholamban (PLN) are pivotal for Ca2+ handling in cardiomyocyte and are known that their expression level and activity were changed in the heart failure patients. To examine whether PLN inhibition can improve survival rate as well as cardiac function in heart failure, we performed PLN ablation in...

Acute aortic occlusion in a patient with chronic paralysis due to spinal cord injury: a case report

Patients with spinal cord injury experience changes in the cardiovascular system and a high morbidity associated with peripheral artery disease. We report a case of acute aortic occlusion in a patient with chronic paralysis due to spinal cord injury. A 65-year-old man with chronic paralysis due to spinal cord injury developed mottling of the right extremity. Because of the...

Environmental DNA reflects spatial and temporal jellyfish distribution

Recent development of environmental DNA (eDNA) analysis allows us to survey underwater macro-organisms easily and cost effectively; however, there have been no reports on eDNA detection or quantification for jellyfish. Here we present the first report on an eDNA analysis of marine jellyfish using Japanese sea nettle (Chrysaora pacifica) as a model species by combining a tank...

Environmental DNA metabarcoding reveals local fish communities in a species-rich coastal sea

Policy Bureau, Ministry of Land, Infrastructure, Transportation and Tourism (, edited by Satoshi Yamamoto]. Full size image Figure 4 ... Solution Technology, Faculty of Science and Technology, Ryukoku University, Shiga, JapanMichio Kondoh AuthorsSearch for Satoshi Yamamoto in:Nature Research journals • PubMed • Google ScholarSearch for Reiji

Acute myocardial infarction with “wrap around” right coronary artery mimicking Takotsubo cardiomyopathy: a case report

Background Takotsubo cardiomyopathy (TC) is a cardiomyopathy that shows distinctive clinical conditions first described more than 20 years ago. Because clinical features of TC mimic those of anterior acute myocardial infarction (AMI), the differential diagnosis is important in selecting the appropriate treatment strategy in the acute phase. But it was difficult to differentiate...

Diet disparity among sympatric herbivorous cichlids in the same ecomorphs in Lake Tanganyika: amplicon pyrosequences on algal farms and stomach contents

Hiroki Hata 0 Akifumi S Tanabe Satoshi Yamamoto Hirokazu Toju Masanori Kohda Michio Hori 0 Graduate School of Science and Engineering, Ehime University , 2-5 Bunkyo, Matsuyama, Ehime , Japan

Sharing of Diverse Mycorrhizal and Root-Endophytic Fungi among Plant Species in an Oak-Dominated Cool–Temperate Forest

Most terrestrial plants interact with diverse clades of mycorrhizal and root-endophytic fungi in their roots. Through belowground plant–fungal interactions, dominant plants can benefit by interacting with host-specific mutualistic fungi and proliferate in a community based on positive plant–mutualistic fungal feedback. On the other hand, subordinate plant species may persist in...

Spatial Segregation and Aggregation of Ectomycorrhizal and Root-Endophytic Fungi in the Seedlings of Two Quercus Species

Diverse clades of mycorrhizal and endophytic fungi are potentially involved in competitive or facilitative interactions within host-plant roots. We investigated the potential consequences of these ecological interactions on the assembly process of root-associated fungi by examining the co-occurrence of pairs of fungi in host-plant individuals. Based on massively-parallel...

Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia

Sympathetic Nerve Endings in Myocardial Ischemia Masashi Tawa,1,2 Satoshi Yamamoto,1,3 Mamoru Ohkita,1 and Yasuo Matsumura1 1Laboratory of Pathological and Molecular Pharmacology, Osaka University of

Aortic Dissection Occurring 18 Months after Successful Endovascular Repair in an Anatomically Difficult Case of Abdominal Aortic Aneurysm

Medicine, The University of Tokyo, Tokyo, Japan Received 9 August 2013; Accepted 25 September 2013 Academic Editors: J.-W. Chen, L. Masotti, and N. Papanas Copyright © 2013 Satoshi Yamamoto et al. This

High-Coverage ITS Primers for the DNA-Based Identification of Ascomycetes and Basidiomycetes in Environmental Samples

The kingdom Fungi is estimated to include 1.5 million or more species, playing key roles as decomposers, mutualists, and parasites in every biome on the earth. To comprehensively understand the diversity and ecology of this huge kingdom, DNA barcoding targeting the internal transcribed spacer (ITS) region of the nuclear ribosomal repeat has been regarded as a prerequisite...

Incipient allochronic speciation by climatic disruption of the reproductive period

Satoshi Yamamoto () 0 Teiji Sota 0 0 Department of Zoology, Graduate School of Science, Kyoto University , Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto 606-8502 , Japan Disruptive selection of life

Xilei San Ameliorates Experimental Colitis in Rats by Selectively Degrading Proinflammatory Mediators and Promoting Mucosal Repair

 Yoko Kogure,1,5 Ken Fukunaga,3 Shinichiro Kashiwamura,6 Satoshi Yamamoto,1 Shiro Nakamura,3 Junxiang Li,7 Hiroto Miwa,2 Koichi Noguchi,4,5 and Yi Dai1,4,5 1Department of Pharmacy, School of Pharmacy

Environmental DNA as a ‘Snapshot’ of Fish Distribution: A Case Study of Japanese Jack Mackerel in Maizuru Bay, Sea of Japan

Recent studies in streams and ponds have demonstrated that the distribution and biomass of aquatic organisms can be estimated by detection and quantification of environmental DNA (eDNA). In more open systems such as seas, it is not evident whether eDNA can represent the distribution and biomass of aquatic organisms because various environmental factors (e.g., water flow) are...

Splenic-intrahepatic left portal shunt in an adult patient with extrahepatic portal vein obstruction without recurrence after pancreaticoduodenectomy

In the last decade, a superior mesenteric-intrahepatic left portal shunt (Rex shunt) has been reported for successful management of extrahepatic portal vein obstruction in children. However, in adults, a mesocaval shunt has been generally performed for the surgical management of extrahepatic portal vein obstruction because of the complexity of the underlying disease and the...

Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer

Background p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis. To investigate the role of these genes in non-small cell lung cancer, we compared the relationship between p53AIP1 or survivin gene expression and the clinicopathological...

Th2 predominance at the single‐cell level in patients with IgA nephropathy

Background. Abnormalities of lymphocyte function have been reported to be involved in the pathogenesis of IgA nephropathy (IgA‐N). The aim of this study was to investigate helper T (Th) predominance at the single‐cell level, one of the abnormalities of lymphocyte function in IgA‐N. Methods. Using flowcytometry, we assessed the levels of circulating Th cells in IgA‐N patients (n...

A simple, noninvasively determined index predicting hepatic failure following liver resection for hepatocellular carcinoma

BackgroundA novel index, the serum aspartate aminotransferase activity/platelet count ratio index (APRI), has been identified as a biochemical surrogate for histological fibrogenesis and fibrosis in cirrhosis. We evaluated the ability of preoperative APRI to predict hepatic failure following liver resection for hepatocellular carcinoma.MethodsPotential preoperative risk factors...

Successful treatment with lamivudine may correlate with reduction of serum ferritin levels in the patients with chronic hepatitis and liver cirrhosis type B

Niigata University , 1-754, Asahimachi-Dori, Niigata-city 951-8122, Japan 1 A study of Niigata-Zeffix investigation meeting 2 Shogo Ohkoshi Akira Yoshimura Satoshi Yamamoto Masahiko Yano So Kurita