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Search: authors:"Schlecht, Nicolas F."

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Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells

Crumbs 3 (CRB3) is a component of epithelial junctions, which has been implicated in apical-basal polarity, apical identity, apical stability, cell adhesion, and cell growth. CRB3 undergoes alternative splicing to yield two variants: CRB3a and CRB3b. Here, we describe novel data demonstrating that, as with previous studies on CRB3a, CRB3b also promotes the formation of tight...

Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers

The epidermal growth factor receptor (EGFR) signaling network is involved in lung carcinogenesis. This study examined whether ligands that activate or suppress the EGFR signaling network were associated with lung cancer risk in ever smokers.

Human Papillomavirus Infection and Time to Progression and Regression of Cervical Intraepithelial Neoplasia

Background: Little is known about the duration of precancerous cervical lesions in relation to human papillomavirus (HPV) infection. We estimated rates of progression and regression and sojourn times of cervical squamous intraepithelial lesions (SILs) according to HPV status. Methods: We used data from a longitudinal study of HPV infection and cervical neoplasia in São Paulo...

Natural History and Possible Reactivation of Human Papillomavirus in Human Immunodeficiency Virus–Positive Women

Background: Little is known in human immunodeficiency virus (HIV)–positive women about how the combination of plasma HIV RNA level and CD4 + T-cell count is associated with the natural history of human papillomavirus (HPV) infection or about HPV reactivation—whether it occurs and with what frequency in HIV-positive women. Methods: HIV-positive (n = 1848) and -negative (n = 514...