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Variants of the PPARD Gene and Their Clinicopathological Significance in Colorectal Cancer

Background Peroxisome proliferator-activated receptor delta (PPARD) is nuclear hormone receptor involved in colorectal cancer (CRC) differentiation and progression. The purpose of this study was to determine prevalence and spectrum of variants in the PPARD gene in CRC, and their contribution to clinicopathological endpoints. Methods and Findings Direct sequencing of the PPARD...

Tafazzin Protein Expression Is Associated with Tumorigenesis and Radiation Response in Rectal Cancer: A Study of Swedish Clinical Trial on Preoperative Radiotherapy

Background Tafazzin (TAZ), a transmembrane protein contributes in mitochondrial structural and functional modifications through cardiolipin remodeling. TAZ mutations are associated with several diseases, but studies on the role of TAZ protein in carcinogenesis and radiotherapy (RT) response is lacking. Therefore we investigated the TAZ expression in rectal cancer, and its...

Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines

BackgroundAstrocyte elevated gene 1 (AEG-1), an important oncogene, has been shown to be overexpressed in several types of cancers. In colorectal cancer (CRC), the protein level of AEG-1 is up-regulated in tumour tissue compared to normal mucosa, showing prognostic significance. Since little is known about the transcriptional level of AEG-1 expression and its biological pathway...

Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines

in a p53 independent apoptotic pathway after DNA damage. Notes Sebastian Gnosa, Yang-Mei Shen contributed equally to this work. Abbreviation AEG-1:  Astrocyte elevated gene 1 CRC:  Colorectal

Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients

Johannes Stratmann 0 Chao-Jie Wang Sebastian Gnosa sa Wallin David Hinselwood Xiao-Feng Sun Hong Zhang 0 0 Division of Biomedicine, Systems Biology Research Centre, School of Life Sciences, Skovde