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14 papers found.
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Comparison of the fixed ratio and the Z-score of FEV1/FVC in the elderly population: a long-term mortality analysis from the Third National Health and Nutritional Examination Survey

Seunghee Baek,2 Sei Won Lee,1 Jae Seung Lee,1 Sang-Do Lee,1 Yeon-Mok Oh1 1Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical ... seunghee Baek 2 sei Won lee 1 Jae seung lee 1 sang-Do lee 1 Background and objective: Despite the ongoing intense debate on the definition of airflow limitation by spirometry in the elderly population, there

Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease

Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease Tae Hoon Kim, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh Department of Pulmonary

Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration

Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration Kang-Hyun Kim,1 Tai Sun Park,2,3 You-Sun Kim,1,3 Jae Seung Lee,2,3 Yeon-Mok Oh,2,3 Sang-Do Lee,2,3 Sei Won Lee2,3 1Asan Institute for Life Sciences, 2Department of Pulmonology and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center...

The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients

-Keun Kim Sunmi Yun Lokesh Sharma Charles S Dela Cruz Jae Seung Lee Yeon-Mok Oh Sang-Do Lee Sei Won Lee Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, and bacterial

Development of a spirometry T-score in the general population

Development of a spirometry T-score in the general population Sei Won Lee,1 Hyun Kuk Kim,2 Seunghee Baek,3 Ji-Ye Jung,4 Young Sam Kim,4 Jae Seung Lee,1 Sang-Do Lee,1 David M Mannino,5 Yeon-Mok Oh1 ... spirometry; T-score; COPD - saee ropF open access to scientific and medical research O r I g I n a l r e s e a r C h sei Won lee 1 hyun Kuk Kim 2 seunghee Baek 3 Ji-Ye Jung4 Young sam Kim 4 Jae seung lee

The Impact of Smoking on Airflow Limitation in Subjects with History of Asthma and Inactive Tuberculosis

Background Although smoking is the most important and modifiable cause of chronic obstructive pulmonary disease (COPD), other risk factors including asthma and tuberculosis (TB) are also associated. It is common for COPD patients to have more than one of these risk factors. The aims of this study were to determine the prevalence of airflow limitation (FEV1/FVC<0.7) according to...

Tuberculin Skin Test Distribution following a Change in BCG Vaccination Policy

Background Epidemiologic data regarding tuberculin skin test (TST) responses are an important basis for TB control strategies. This study analyzed TST responses in Korea, which experienced a rapid change in BCG vaccination status. Methods TST responses in young adults were examined over 5 years. Participants with active TB lesions were excluded. Results A total of 5,552...

Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report

Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report Tai Sun Park,1 Yoonki Hong,2 Jae Seung Lee,1 Sang Young Oh,3 Sang Min Lee,3 Namkug Kim,3 Joon Beom Seo,3 Yeon-Mok Oh,1 Sang-Do Lee,1 Sei Won Lee1 1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan...

The clinical utility of tuberculin skin test and interferon-γ release assay in the diagnosis of active tuberculosis among young adults: a prospective observational study

Background The roles of the tuberculin skin test (TST) and QuantiFERON®-TB Gold In-Tube assay (QFT-IT) in the diagnosis of active tuberculosis (TB) are not clear in young adults. We evaluated the diagnostic accuracy of the TST and QFT-IT in smear-negative TB among young adults with no underlying disease. Methods We prospectively enrolled 166 young participants 20-29 years of age...

Serial interferon-gamma release assays during treatment of active tuberculosis in young adults

Background The role of interferon-γ release assay (IGRA) in monitoring responses to anti-tuberculosis (TB) treatment is not clear. We evaluated the results of the QuantiFERON-TB Gold In-tube (QFT-GIT) assay over time during the anti-TB treatment of adults with no underlying disease. Methods We enrolled soldiers who were newly diagnosed with active TB and admitted to the central...

Phenotyping of chronic obstructive pulmonary disease: heterogeneity and its clinical relevance

Chronic obstructive pulmonary disease (COPD) is a spectrum of various syndromes that share airflow limitation but differ in many respects. Although airflow limitation is a defining element of COPD, forced expiratory volume in 1 s (FEV1) alone is not sufficient to explain the heterogeneity of COPD. Phenotypic characterization of clinically relevant subgroups of COPD will increase...

The health care burden of high grade chronic obstructive pulmonary disease in Korea: analysis of the Korean Health Insurance Review and Assessment Service data

Yoo,3 Young Sam Kim,4 Sei Won Lee,5 Yong Bum Park,6 Jin Hwa Lee,7 YeonMok Oh,5 Sang Do Lee,5 Yuri Kim,8 KyungJoo Kim,8 HyoungKyu Yoon9 1Office of Health Service Research, National Evidence-Based ... 4 sei Won lee 5 Jin hwa lee 7 sang Do lee 5 hyoungKyu Yoon 9 cally and economically. Background: Patients with high grade chronic pulmonary obstructive disease (COPD) account for much of the COPD

The association of down-regulated toll-like receptor 4 expression with airflow limitation and emphysema in smokers

Background An association between innate immunity including Toll-like receptors (TLRs) and COPD is reported recently; TLR4 deficiency in lung can cause emphysema in animals, which is not evident in humans. We analyzed the association of TLR4 expression, airflow limitation and emphysema in smokers. Methods We enrolled patients of ≥40years old with smoking histories of ≥10 pack...

Biological Resistance of Hydroxychloroquine for Plasmodium vivax Malaria in the Republic of Korea

The Republic of Korea (ROK) Army instituted a vivax malaria chemoprophylaxis program (hydroxychloroquine [HCQ] 400 mg per week) in 1997 that was expanded to nearly 200,000 soldiers by 2007, raising concerns for the emergence of drug-resistant vivax malaria. Therefore, a study of whole blood HCQ concentrations for all malaria patients admitted to four ROK Army hospitals was...