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Search: authors:"Seiichi Kobayashi"

8 papers found.
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Inflammatory biomarkers in asthma-COPD overlap syndrome

Inflammatory biomarkers in asthma-COPD overlap syndrome Seiichi Kobayashi, Masakazu Hanagama, Shinsuke Yamanda, Masatsugu Ishida, Masaru YanaiDepartment of Respiratory Medicine, Japanese Red Cross

Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis

Background Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis. Although the median survival is 3 years, the clinical course varies to a large extent among IPF patients. To date, there has been no definitive prognostic marker. Extracellular vesicles (EVs) are known to hold nucleic acid, including microRNAs, and to regulate gene expression in the recipient cells...

AutoGPA: An Automated 3D-QSAR Method Based on Pharmacophore Alignment and Grid Potential Analysis

3D-QSAR approach has been widely applied and proven to be useful in the case where no reliable crystal structure of the complex between a biologically active molecule and the receptor is available. At the same time, however, it also has highlighted the sensitivity of this approach. The main requirement of the traditional 3D-QSAR method is that molecules should be correctly...

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

Research journals • PubMed • Google ScholarSearch for Seiichi Kobayashi in:Nature Research journals • PubMed • Google ScholarSearch for Kota Ishizawa in:Nature Research journals • PubMed • Google

Prevention of acute and chronic allograft rejection by a novel retinoic acid receptor‐α‐selective agonist

To investigate the involvement of retinoic acid receptor (RAR)‐α in allograft rejection, we investigated the effect of a novel selective agonist to the receptor, ER‐38925, in a mouse cardiac allograft model. Prophylactic treatment with ER‐38925 inhibited the acute rejection of the mouse cardiac allograft (BALB/c → C3H/HeN) at 0.3 and 3 mg/kg, and its effect was enhanced in...