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Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain

Melatonin is a well-known potent endogenous antioxidant pharmacological agent with significant neuroprotective actions. Here in the current study, we explored the nuclear factor erythroid 2-related factor 2 (Nrf2) gene-dependent antioxidant mechanism underlying the neuroprotective effects of the acute melatonin against acute ethanol-induced elevated reactive oxygen species (ROS...

Nyctanthes arbor-tristis Ameliorated FCA-Induced Experimental Arthritis: A Comparative Study among Different Extracts

Nyctanthes arbor-tristis (NAT) is commonly used traditionally for the treatment of rheumatism and inflammatory diseases. Current study evaluates the antiarthritic potential of NAT using Freund’s adjuvant-induced arthritic rat model. Treatments with methanolic, ethyl acetate, and n-hexane extracts were continued for consecutive 20 days. Macroscopic arthritic scoring and water...

An Approach to Model Based Testing of Multiagent Systems

June 2014; Revised 11 September 2014; Accepted 14 September 2014 Academic Editor: Shifei Ding Copyright © 2015 Shafiq Ur Rehman and Aamer Nadeem. This is an open access article distributed under the

Frozen Jacobian Multistep Iterative Method for Solving Nonlinear IVPs and BVPs

In this paper, we present and illustrate a frozen Jacobian multistep iterative method to solve systems of nonlinear equations associated with initial value problems (IVPs) and boundary value problems (BVPs). We have used Jacobi-Gauss-Lobatto collocation (J-GL-C) methods to discretize the IVPs and BVPs. Frozen Jacobian multistep iterative methods are computationally very efficient...

Frozen Jacobian Multistep Iterative Method for Solving Nonlinear IVPs and BVPs

In this paper, we present and illustrate a frozen Jacobian multistep iterative method to solve systems of nonlinear equations associated with initial value problems (IVPs) and boundary value problems (BVPs). We have used Jacobi-Gauss-Lobatto collocation (J-GL-C) methods to discretize the IVPs and BVPs. Frozen Jacobian multistep iterative methods are computationally very efficient...

Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain

Glutamate-induced excitotoxicity, oxidative damage, and neuroinflammation are believed to play an important role in the development of a number of CNS disorders. We recently reported that a high dose of glutamate could induce AMPK-mediated neurodegeneration in the postnatal day 7 (PND7) rat brain. Yet, the mechanism of glutamate-induced oxidative stress and neuroinflammation in...

Spectral reflectance indices as a rapid and nondestructive phenotyping tool for estimating different morphophysiological traits of contrasting spring wheat germplasms under arid conditions

The aim of this study was to investigate whether spectral reflectance indices could be used to estimate different destructive morphophysiological traits of a wide and diverse range of spring wheat germplasm in a rapid and nondestructive manner. A total of 90 spring wheat germoplasms were evaluated under water shortage by applying only three irrigations during the growing cycle of...

Correction: Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

Cell Model Faiz Ahmed Raza Shafiq ur Rehman Ruqyya Khalid Jameel Ahmad Sajjad Ashraf Mazhar Iqbal Shahida Hasnain Figs 2, 3, 4, and 5 are each missing an internal color legend. The authors have

Demographic and Clinico-Epidemiological Features of Dengue Fever in Faisalabad, Pakistan

This cross-sectional study was carried out to explore the epidemiological and clinical features of dengue fever in Faisalabad, Pakistan during 2011 and 2012. During the study period, anti-dengue IgM positive cases were reported in the post-monsoon period during the months of August–December. Certain hotspots for the dengue infection were identified in the city that coincide with...

An intervention to stop smoking among patients suspected of TB - evaluation of an integrated approach

Background In many low- and middle-income countries, where tobacco use is common, tuberculosis is also a major problem. Tobacco use increases the risk of developing tuberculosis, secondary mortality, poor treatment compliance and relapses. In countries with TB epidemic, even a modest relative risk leads to a significant attributable risk. Treating tobacco dependence, therefore...