Advanced search    

Search: authors:"Shan Tang"

53 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne

Ethylene and ethyne are among the simplest two-carbon building blocks. However, quite limited methods can be applied to incorporate ethylene or ethyne into fine chemicals. Here we demonstrate a cobalt-catalyzed dehydrogenative C–H/N–H [4+2] annulation of aryl/vinyl amides with ethylene or ethyne by using an electrochemical reaction protocol. Significantly, this work shows an...

External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives

Shan Tang contributed equally to this work. AffiliationsCollege of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, Hubei, ChinaKun Liu, Shan ... AuthorsSearch for Kun Liu in:Nature Research journals • PubMed • Google Scholar Search for Shan Tang in:Nature Research journals • PubMed • Google Scholar Search for Pengfei Huang in:Nature Research journals

Computational Modeling of the Effect of Sulci during Tumor Growth and Cerebral Edema

declare that they have no competing interests. Acknowledgments Dan Peng appreciates the support of NHFPC of Chongqing (Project no. 2015MSXM075). Shan Tang thanks ?Young Thousand Talented Program,? NSF of

Computational Modeling of the Effect of Sulci during Tumor Growth and Cerebral Edema

declare that they have no competing interests. Acknowledgments Dan Peng appreciates the support of NHFPC of Chongqing (Project no. 2015MSXM075). Shan Tang thanks “Young Thousand Talented Program,” NSF of

Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells

assisted in the extraction, isolation and characterization of ATB. Xin-xin ZHANG, Jin-shan TANG, and Yong GAN designed and directed the study and participated in the overall editing and approval of the paper

Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy

Tuanyao Chai Tie-Shan Tang OPEN Mitochondrial sequestration by autophagosomes is a key step in mitophagy while the mechanisms mediating this process are not fully understood. It has been reported that

Optimization of Phenolics Extracted from Idesia polycarpa Defatted Fruit Residue and Its Antioxidant and Depigmenting Activity In Vitro and In Vivo

Extraction of phenolics from Idesia polycarpa defatted fruit residue was optimized by the maximization of the yield in total phenolics, using the response surface methodology. The optimized conditions were 50% ethanol, 5 h extraction time, 1 : 40 liquid to solid ratio, and 80°C extraction temperature. The experimental average total phenolics yield was  mg/g. These antioxidant...

The scaling conditions for ASP flooding oilfield in the fourth Plant of Daqing oilfield

The fourth Plant of Daqing oilfield which uses ASP flooding has a serious foul water problem. So, scaling conditions were analyzed to discuss the petroleum production and oil–gas–water treatment. In the flooding process in stratum, scaling in the ASP flooding is because of chemical condition changes. The silica and aluminum irons in the rocks are dissolved in the formation water...

CSB-PGBD3 Mutations Cause Premature Ovarian Failure

Premature ovarian failure (POF) is a rare, heterogeneous disorder characterized by cessation of menstruation occurring before the age of 40 years. Genetic etiology is responsible for perhaps 25% of cases, but most cases are sporadic and unexplained. In this study, through whole exome sequencing in a non-consanguineous family having four affected members with POF and Sanger...

COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production

Innate antiviral immunity is the first line of the host defense system that rapidly detects invading viruses. Mitochondria function as platforms for innate antiviral signal transduction in mammals through the adaptor protein, MAVS. Excessive activation of MAVS-mediated antiviral signaling leads to dysfunction of mitochondria and cell apoptosis that likely causes the pathogenesis...

Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal

Thimerosal is a vaccine antimicrobial preservative which has long been suspected an iatrogenic factor possibly contributing to neurodevelopmental disorders including autism. The association between infant vaccine thimerosal exposure and autism remains an open question. Although thimerosal has been removed from mandatory childhood vaccines in the United States, thimerosal...

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

REV1 is a eukaryotic member of the Y-family of DNA polymerases involved in translesion DNA synthesis and genome mutagenesis. Recently, REV1 is also found to function in homologous recombination. However, it remains unclear how REV1 is recruited to the sites where homologous recombination is processed. Here, we report that loss of mammalian REV1 results in a specific defect in...

Tetrabenazine is neuroprotective in Huntington's disease mice

Background Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in Huntingtin protein (Htt). PolyQ expansion in Httexp causes selective degeneration of striatal medium spiny neurons (MSN) in HD patients. A number of previous studies suggested that dopamine signaling plays an important role in HD pathogenesis. A specific inhibitor...

Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation

Translesion DNA synthesis (TLS) can use specialized DNA polymerases to insert and/or extend nucleotides across lesions, thereby limiting stalled replication fork collapse and the potential for cell death. Recent studies have shown that monoubiquitinated proliferating cell nuclear antigen (PCNA) plays an important role in recruitment of Y-family TLS polymerases to stalled...

Pharmacokinetics of repeated doses of misoprostol

BACKGROUND Misoprostol is widely used in obstetrics and gynaecology for medical abortion, cervical priming and induction of labour. To aid the design of effective and safe regimens, we have investigated the pharmacokinetic parameters after the vaginal or sublingual administration of repeated doses of 400 µg of misoprostol. METHODS Women undergoing termination of pregnancy by...

Sublingual misoprostol for first trimester termination of pregnancy: safety concerns

, National University of Singapore , Singapore 119074 2 Oi-Shan Tang Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital , 6/F Professional Block, 102 Pokfulam Rd, Pokfulam

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine. While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is known about its genomic distribution and function(s) in neurodegenerative diseases such as Huntington's disease (HD). We here observed a marked reduction of the 5-hmC signal in YAC128 (yeast artificial...

Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience

Objective To assess the usefulness of contrast–enhanced ultrasound (CEUS) in differentiating malignant from benign gallbladder (GB) diseases. Methods This study had institutional review board approval. 192 patients with GB diseases from 9 university hospitals were studied. After intravenous bonus injection of a phospholipid-stabilized shell microbubble contrast agent, lesions...

Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

DNA double-strand breaks (DSBs) are highly cytotoxic lesions and pose a major threat to genome stability if not properly repaired. We and others have previously shown that a class of DSB-induced small RNAs (diRNAs) is produced from sequences around DSB sites. DiRNAs are associated with Argonaute (Ago) proteins and play an important role in DSB repair, though the mechanism through...