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Comparative transcriptome analysis reveals significant metabolic alterations in eri-silkworm (Samia cynthia ricini) haemolymph in response to 1-deoxynojirimycin

. Formal analysis: Shang-Zhi Zhang, Hai-Zhong Yu, Ming-Jie Deng, Yan Ma. Funding acquisition: Yan Meng, Jia-Ping Xu. Investigation: Shang-Zhi Zhang, Hai-Zhong Yu, Yan Ma, Dong-Qiong Fei, Jie Wang, Zhen Li ... . Visualization: Shang-Zhi Zhang, Hai-Zhong Yu. Writing ± original draft: Shang-Zhi Zhang, Hai-Zhong Yu. Writing ± review & editing: Jia-Ping Xu. 12 / 14 13 / 14 1. Ji X , Gai Y , Zheng C , Mu Z. Comparative

Metabolic changes in the midgut of Eri silkworm after Oral administration of 1-deoxynojirimycin: A 1H-NMR-based metabonomic study

1-deoxynojirimycin (DNJ) is a natural D-glucose analogue and has a strong physiological activity in inhibiting α-glucosidase in vivo. The antidiabetic effects of DNJ in mice or other mammals were extensively explored, but the physiological and toxic roles of DNJ in insects was seldom reported. In this study, the biological effects of DNJ were examined in midgut extracts of fourth...

Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near-Isogenic Resistant Strains

Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the primary pathogens causing severe economic losses in sericulture. However, the molecular mechanism of silkworm resistance to BmNPV remains largely unknown. Here, the recurrent parent P50 (susceptible strain) and the near-isogenic line BC9 (resistance strain) were used in a comparative transcriptome study examining the response...