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28 papers found.
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Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity

, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency

-E-194-045-MY3, MOST104-2627B-194-001, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or

Self-Powered Active Sensor with Concentric Topography of Piezoelectric Fibers

In this study, we demonstrated a flexible and self-powered sensor based on piezoelectric fibers in the diameter range of nano- and micro-scales. Our work is distinctively different from previous electrospinning research; we fabricated this apparatus precisely via near-field electrospinning which has a spectacular performance to harvest mechanical deformation in arbitrary...

Use of Myometrium as an Internal Reference for Endometrial and Cervical Cancer on Multiphase Contrast-Enhanced MRI

Background Myometrial smooth muscle is normally within the field of view for the gynecological imaging. This study aimed to investigate the use of normal myometrium as an internal reference for endometrial and cervical cancer during multiphase contrast-enhanced magnetic resonance imaging (MCE-MRI) and to explore whether this information regarding tumor enhancement relative to the...

Fuzzy optimization for detecting enzyme targets of human uric acid metabolism

Motivation: Mathematical modeling and optimization have been used for detecting enzyme targets in human metabolic disorders. Such optimal drug design methods are generally differentiated as two stages, identification and decision-making, to find optimal targets. We developed a unified method named fuzzy equal metabolic adjustment to formulate an optimal enzyme target design...

Impacts of Pond Change on the Regional Sustainability of Water Resources in Taoyuan, Taiwan

Taoyuan tableland faces the increasing water demand associated with the expansion of industrialization and urbanization. The county currently relies on the Shihmen Reservoir as the single water supply system. It will be of great concern in the shortage of water resources. This study aims to explore the impact of changes in farm ponds on the regional agricultural environment in...

Impacts of Pond Change on the Regional Sustainability of Water Resources in Taoyuan, Taiwan

Taoyuan tableland faces the increasing water demand associated with the expansion of industrialization and urbanization. The county currently relies on the Shihmen Reservoir as the single water supply system. It will be of great concern in the shortage of water resources. This study aims to explore the impact of changes in farm ponds on the regional agricultural environment in...

Effects of Computer Navigation versus Conventional Total Knee Arthroplasty on Endothelial Damage Marker Levels: A Prospective Comparative Study

Total knee arthroplasty (TKA) inevitably perturbs the femoral medullary canal, which increases blood loss or morbidities associated with marrow embolization postoperatively. Computer navigation TKA reportedly minimizes medullary disturbance to alleviate perioperative blood loss. We performed a prospective comparative study, enrolling 87 patients with osteoarthritic knees from...

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

Background Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and that its downregulation influences the activation of hepatic stellate cells (HSCs). In addition, inhibition of the activity of histone deacetylases 4 (HDAC4) has been shown to strongly reduce HSC activation in the context of liver fibrosis. Objectives In this study, we...

Self-assembly behaviors of thermal- and pH- sensitive magnetic nanocarriers for stimuli-triggered release

In the present work, we prepare thermo- and pH-sensitive polymer-based nanoparticles incorporating with magnetic iron oxide as the remote-controlled, stimuli-response nanocarriers. Well-defined, dual functional tri-block copolymer poly[(acrylic acid)-block-(N-isopropylacrylamide)-block-(acrylic acid)], was synthesized via reversible addition-fragmentation chain-transfer (RAFT...

Multi-objective optimization of enzyme manipulations in metabolic networks considering resilience effects

Background Improving the synthesis rate of desired metabolites in metabolic systems is one of the main tasks in metabolic engineering. In the last decade, metabolic engineering approaches based on the mathematical optimization have been used extensively for the analysis and manipulation of metabolic networks. Experimental evidence shows that mutants reflect resilience phenomena...

EUS assisted transmural cholecystogastrostomy fistula creation as a bridge for endoscopic internal gallbladder therapy using a novel fully covered metal stent

Background Laparoscopic cholecystectomy (LC) has become the “gold standard” for treating symptomatic gallstones. Innovative methods, such as a scarless therapeutic procedure through a natural orifice are being introduced, and include transgastric or transcolonic endoscopic cholecystectomy. However, before clinical implementation, instruments still need modification, and a more...

Clinicopathological analysis of colorectal carcinoid tumors and patient outcomes

Background Colorectal carcinoid tumors are often described as being low-grade malignant. The objective of the current study was to address the clinicopathological features and outcomes of patients with colorectal carcinoid tumors. Methods A total of 63 patients with colorectal carcinoid tumors were identified and evaluated using surgical pathology files and medical records...

Inference of biochemical network models in S-system using multiobjective optimization approach

Pang-Kai Liu 0 Feng-Sheng Wang 0 Associate Editor: John Quackenbush 0 Department of Chemical Engineering, National Chung Cheng University , Chiayi 621-02, Taiwan , ROC Motivation: The inference of

Incoherent production reactions of positive and negative ions in matrix-assisted laser desorption/ionization

Utilizing synchronized dual-polarity matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, we found good evidence of the incoherent production of positive and negative matrix ions. Using thin, homogeneous 2,5-dehydroxybenzoic acid (DHB) matrix films, positive and negative matrix ions were found to appear at different threshold laser fluences. The presence of...

Estimating parameters for generalized mass action models with connectivity information

Background Determining the parameters of a mathematical model from quantitative measurements is the main bottleneck of modelling biological systems. Parameter values can be estimated from steady-state data or from dynamic data. The nature of suitable data for these two types of estimation is rather different. For instance, estimations of parameter values in pathway models, such...

Synchronized dual-polarity electrospray ionization mass spectrometry

This work describes the synchronized dual-polarity (DP) electrospray ionization (ESI) method and demonstrates the first DP ESI mass spectra obtained using two mass spectrometers. Stable double Taylor cones were produced by applying two counter electric voltages with opposite polarities to one electrosprayer. The development of double Taylor cones required higher extraction...

Evolutionary optimization with data collocation for reverse engineering of biological networks

Motivation: Modern experimental biology is moving away from analyses of single elements to whole-organism measurements. Such measured time-course data contain a wealth of information about the structure and dynamic of the pathway or network. The dynamic modeling of the whole systems is formulated as a reverse problem that requires a well-suited mathematical model and a very...

Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis

BackgroundNasopharyngeal carcinoma (NPC) is known for its high metastatic potential and locoregional recurrence, although the molecular alterations that are driving NPC metastasis remain unclear at this time. This study aimed to examine the expression of fibulin-5 in NPC, correlate the results with clinicopathological variables and survival, and to investigate the role of fibulin...

Using the decomposed theory of planning behavioural to analyse consumer behavioural intention towards mobile text message coupons

The rapid development and expansion of the global mobile phone market have made mobile phones another vital marketing communication channel, next to electronic and print media. Sending discount coupons through mobile phone text messages or short message service (m-coupons) has become the latest sales promotion trend for companies. As such, the factors influencing attitude and...