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Effect of ZFN-edited myostatin loss-of-function mutation on gut microbiota in Meishan pigs

Li. Methodology: Sheng-Wang Jiang, Li-Li Qian, Chun-Bo Cai. Project administration: Wen-Tao Cui, Shan-Shan Xie, Ting Gao. Resources: Kui Li. Writing ? original draft: Wen-Tao Cui, Gao-Jun Xiao

Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity

, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency

-E-194-045-MY3, MOST104-2627B-194-001, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or

Physiological and genomic features of a novel violacein-producing bacterium isolated from surface seawater

Strains JW1T and JW3, isolated from surface seawater of the Arabian Sea, were subjected to polyphasic taxonomic analysis. Cells of both strains were Gram-stain-negative, aerobic, and rod-shaped. They formed violet pigment and produced violacein. On the basis of 16S rRNA gene sequence analysis, strains JW1T and JW3 showed high 16S rRNA gene sequence similarity with...

Study on association of working hours and occupational physical activity with the occurrence of coronary heart disease in a Chinese population

) Scales. (DOCX) S1 File. STROBE checklist. (DOCX) Author Contributions Conceptualization: Lian-Sheng Wang. Data curation: Hao-Jie Shi. Formal analysis: Hao-Jie Shi, Hao Wang. Funding acquisition: Lian ... -Sheng Wang. Investigation: Mohammad Reeaze Khurwolah. Methodology: Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Yang Yang. Project administration: Yao Ma. Resources: Mohammad Reeaze Khurwolah, Ya-Fei Li

Spectroscopic characterization of DOM and the nitrogen removal mechanism during wastewater reclamation plant

Contributions Conceptualization: Xiang Li, Ming-Xuan Cai. Data curation: Lei Wang, Ying-Jun Li, Xiang Li, Xiao-Shu Wang, Jian-feng Xu, Tong-Tong Li, Jin-Sheng Wang. Formal analysis: Lei Wang, Jian-feng Xu ... . Resources: Lei Wang, Di-Hua Wang. Software: Wen-Bing Tan. Supervision: Ming-Xuan Cai, Bei-Dou Xi. Writing ± original draft: Lei Wang, Ying-Jun Li, Jin-Sheng Wang. Writing ± review & editing: Lei Wang

Use of Myometrium as an Internal Reference for Endometrial and Cervical Cancer on Multiphase Contrast-Enhanced MRI

Background Myometrial smooth muscle is normally within the field of view for the gynecological imaging. This study aimed to investigate the use of normal myometrium as an internal reference for endometrial and cervical cancer during multiphase contrast-enhanced magnetic resonance imaging (MCE-MRI) and to explore whether this information regarding tumor enhancement relative to the...

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

Background Minor ischemic stroke (MIS) represents a major global public health problem worldwide due to high incidence. The aim of this study was to investigate whether metabolic syndrome (MetS) is a strong risk for MIS and subsequent vascular events (SVE). Methods A retrospective cohort study was performed examining symptomatic MIS in a Chinese neurologic outpatient population...

Correction: Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses

Sisi Luo Jiaoling Huang Yanfang Zhang Tingting Zeng Sheng Wang Jiabo Liu Yaoshan Pang There is an error in the Funding section. The correct funding information is as follows: This work was supported by

Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses

Foot-and-mouth disease virus (FMDV), Bluetongue virus (BTV), Vesicular stomatitis Virus (VSV), Bovine viral diarrheal (BVDV), Bovine rotavirus (BRV), and Bovine herpesvirus 1 (IBRV) are common cattle infectious viruses that cause a great economic loss every year in many parts of the world. A rapid and high-throughput GenomeLab Gene Expression Profiler (GeXP) analyzer-based...

A Scheme to Optimize Flow Routing and Polling Switch Selection of Software Defined Networks

This paper aims at minimizing the communication cost for collecting flow information in Software Defined Networks (SDN). Since flow-based information collecting method requires too much communication cost, and switch-based method proposed recently cannot benefit from controlling flow routing, jointly optimize flow routing and polling switch selection is proposed to reduce the...

MRFalign: Protein Homology Detection through Alignment of Markov Random Fields

Sequence-based protein homology detection has been extensively studied and so far the most sensitive method is based upon comparison of protein sequence profiles, which are derived from multiple sequence alignment (MSA) of sequence homologs in a protein family. A sequence profile is usually represented as a position-specific scoring matrix (PSSM) or an HMM (Hidden Markov Model...

A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork

Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats...

Local Plasticity of Dendritic Excitability Can Be Autonomous of Synaptic Plasticity and Regulated by Activity-Based Phosphorylation of Kv4.2

While plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains unknown whether modulation of dendritic excitability is controlled by synaptic...

The Frequency of Patient-Initiated Violence and Its Psychological Impact on Physicians in China: A Cross-Sectional Study

Introduction In China, the severity of medical disputes has greatly increased during the past two decades, which has caused various adverse outcomes for health professionals. Previous research on violence in healthcare settings has primarily examined the occurrence of patient-initiated violence and its effects on physicians, but few studies have focused on the impact of the...

Effects of Computer Navigation versus Conventional Total Knee Arthroplasty on Endothelial Damage Marker Levels: A Prospective Comparative Study

Total knee arthroplasty (TKA) inevitably perturbs the femoral medullary canal, which increases blood loss or morbidities associated with marrow embolization postoperatively. Computer navigation TKA reportedly minimizes medullary disturbance to alleviate perioperative blood loss. We performed a prospective comparative study, enrolling 87 patients with osteoarthritic knees from...

Impaired Function of CD4+ T Follicular Helper (Tfh) Cells Associated with Hepatocellular Carcinoma Progression

described. - Competing Interests: Fu-Sheng Wang is a PLOS ONE Editorial Board member, and declares that this A total of 85 HCC patients with hepatitis B virus (HBV) infection, 25 HBV-relative liver

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

Background Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and that its downregulation influences the activation of hepatic stellate cells (HSCs). In addition, inhibition of the activity of histone deacetylases 4 (HDAC4) has been shown to strongly reduce HSC activation in the context of liver fibrosis. Objectives In this study, we...

Blood pressure and expression of microRNAs in whole blood

Background Blood pressure (BP) is a complex, multifactorial clinical outcome driven by genetic susceptibility, behavioral choices, and environmental factors. Many molecular mechanisms have been proposed for the pathophysiology of high BP even as its prevalence continues to grow worldwide, increasing morbidity and marking it as a major public health concern. To address this, we...

Discovering Link Communities in Complex Networks by an Integer Programming Model and a Genetic Algorithm

Identification of communities in complex networks is an important topic and issue in many fields such as sociology, biology, and computer science. Communities are often defined as groups of related nodes or links that correspond to functional subunits in the corresponding complex systems. While most conventional approaches have focused on discovering communities of nodes, some...