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Effect of ZFN-edited myostatin loss-of-function mutation on gut microbiota in Meishan pigs

Li. Methodology: Sheng-Wang Jiang, Li-Li Qian, Chun-Bo Cai. Project administration: Wen-Tao Cui, Shan-Shan Xie, Ting Gao. Resources: Kui Li. Writing ? original draft: Wen-Tao Cui, Gao-Jun Xiao

Explicit bounds of unknown function of some new weakly singular retarded integral inequalities for discontinuous functions and their applications

The purpose of the present paper is to establish some new retarded weakly singular integral inequalities of Gronwall-Bellman type for discontinuous functions, which generalize some known weakly singular and impulsive integral inequalities. The inequalities given here can be used in the analysis of the qualitative properties of certain classes of singular differential equations...

Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity

, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency

-E-194-045-MY3, MOST104-2627B-194-001, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or

AUCpreD: proteome-level protein disorder prediction by AUC-maximized deep convolutional neural fields

Motivation: Protein intrinsically disordered regions (IDRs) play an important role in many biological processes. Two key properties of IDRs are (i) the occurrence is proteome-wide and (ii) the ratio of disordered residues is about 6%, which makes it challenging to accurately predict IDRs. Most IDR prediction methods use sequence profile to improve accuracy, which prevents its...

Physiological and genomic features of a novel violacein-producing bacterium isolated from surface seawater

Strains JW1T and JW3, isolated from surface seawater of the Arabian Sea, were subjected to polyphasic taxonomic analysis. Cells of both strains were Gram-stain-negative, aerobic, and rod-shaped. They formed violet pigment and produced violacein. On the basis of 16S rRNA gene sequence analysis, strains JW1T and JW3 showed high 16S rRNA gene sequence similarity with...

Study on association of working hours and occupational physical activity with the occurrence of coronary heart disease in a Chinese population

) Scales. (DOCX) S1 File. STROBE checklist. (DOCX) Author Contributions Conceptualization: Lian-Sheng Wang. Data curation: Hao-Jie Shi. Formal analysis: Hao-Jie Shi, Hao Wang. Funding acquisition: Lian ... -Sheng Wang. Investigation: Mohammad Reeaze Khurwolah. Methodology: Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Yang Yang. Project administration: Yao Ma. Resources: Mohammad Reeaze Khurwolah, Ya-Fei Li

CMsearch: simultaneous exploration of protein sequence space and structure space improves not only protein homology detection but also protein structure prediction

Motivation: Protein homology detection, a fundamental problem in computational biology, is an indispensable step toward predicting protein structures and understanding protein functions. Despite the advances in recent decades on sequence alignment, threading and alignment-free methods, protein homology detection remains a challenging open problem. Recently, network methods that...

Protein contact prediction by integrating joint evolutionary coupling analysis and supervised learning

Motivation: Protein contact prediction is important for protein structure and functional study. Both evolutionary coupling (EC) analysis and supervised machine learning methods have been developed, making use of different information sources. However, contact prediction is still challenging especially for proteins without a large number of sequence homologs. Results: This article...

Use of Myometrium as an Internal Reference for Endometrial and Cervical Cancer on Multiphase Contrast-Enhanced MRI

Background Myometrial smooth muscle is normally within the field of view for the gynecological imaging. This study aimed to investigate the use of normal myometrium as an internal reference for endometrial and cervical cancer during multiphase contrast-enhanced magnetic resonance imaging (MCE-MRI) and to explore whether this information regarding tumor enhancement relative to the...

Spectroscopic characterization of DOM and the nitrogen removal mechanism during wastewater reclamation plant

Contributions Conceptualization: Xiang Li, Ming-Xuan Cai. Data curation: Lei Wang, Ying-Jun Li, Xiang Li, Xiao-Shu Wang, Jian-feng Xu, Tong-Tong Li, Jin-Sheng Wang. Formal analysis: Lei Wang, Jian-feng Xu ... . Resources: Lei Wang, Di-Hua Wang. Software: Wen-Bing Tan. Supervision: Ming-Xuan Cai, Bei-Dou Xi. Writing ± original draft: Lei Wang, Ying-Jun Li, Jin-Sheng Wang. Writing ± review & editing: Lei Wang

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

Background Minor ischemic stroke (MIS) represents a major global public health problem worldwide due to high incidence. The aim of this study was to investigate whether metabolic syndrome (MetS) is a strong risk for MIS and subsequent vascular events (SVE). Methods A retrospective cohort study was performed examining symptomatic MIS in a Chinese neurologic outpatient population...

Exploiting ontology graph for predicting sparsely annotated gene function

Motivation: Systematically predicting gene (or protein) function based on molecular interaction networks has become an important tool in refining and enhancing the existing annotation catalogs, such as the Gene Ontology (GO) database. However, functional labels with only a few (<10) annotated genes, which constitute about half of the GO terms in yeast, mouse and human, pose a...

Correction: Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses

Sisi Luo Jiaoling Huang Yanfang Zhang Tingting Zeng Sheng Wang Jiabo Liu Yaoshan Pang There is an error in the Funding section. The correct funding information is as follows: This work was supported by

Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses

Foot-and-mouth disease virus (FMDV), Bluetongue virus (BTV), Vesicular stomatitis Virus (VSV), Bovine viral diarrheal (BVDV), Bovine rotavirus (BRV), and Bovine herpesvirus 1 (IBRV) are common cattle infectious viruses that cause a great economic loss every year in many parts of the world. A rapid and high-throughput GenomeLab Gene Expression Profiler (GeXP) analyzer-based...

A Scheme to Optimize Flow Routing and Polling Switch Selection of Software Defined Networks

This paper aims at minimizing the communication cost for collecting flow information in Software Defined Networks (SDN). Since flow-based information collecting method requires too much communication cost, and switch-based method proposed recently cannot benefit from controlling flow routing, jointly optimize flow routing and polling switch selection is proposed to reduce the...

Fuzzy optimization for detecting enzyme targets of human uric acid metabolism

Motivation: Mathematical modeling and optimization have been used for detecting enzyme targets in human metabolic disorders. Such optimal drug design methods are generally differentiated as two stages, identification and decision-making, to find optimal targets. We developed a unified method named fuzzy equal metabolic adjustment to formulate an optimal enzyme target design...

Some new generalized retarded nonlinear integral inequalities with iterated integrals and their applications

Some new generalized retarded nonlinear integral inequalities with iterated integrals are discussed and upper bound estimations of unknown functions are given by analysis technique. These estimations can be used as tools in the study of differential-integral equations with the initial conditions.MSC: 26D10, 26D15, 26D20, 34A12, 34A40.

A class of retarded nonlinear integral inequalities and its application in nonlinear differential-integral equation

In this paper, we discuss a class of retarded nonlinear integral inequalities and give an upper bound estimation of an unknown function by the integral inequality technique. This estimation can be used as a tool in the study of differential-integral equations with the initial conditions.MSC: 26D10, 26D15, 26D20, 34A12, 34A40.

A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork

Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats...