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Effect of ZFN-edited myostatin loss-of-function mutation on gut microbiota in Meishan pigs

Li. Methodology: Sheng-Wang Jiang, Li-Li Qian, Chun-Bo Cai. Project administration: Wen-Tao Cui, Shan-Shan Xie, Ting Gao. Resources: Kui Li. Writing ? original draft: Wen-Tao Cui, Gao-Jun Xiao

Spectroscopic characterization of DOM and the nitrogen removal mechanism during wastewater reclamation plant

Contributions Conceptualization: Xiang Li, Ming-Xuan Cai. Data curation: Lei Wang, Ying-Jun Li, Xiang Li, Xiao-Shu Wang, Jian-feng Xu, Tong-Tong Li, Jin-Sheng Wang. Formal analysis: Lei Wang, Jian-feng Xu ... . Resources: Lei Wang, Di-Hua Wang. Software: Wen-Bing Tan. Supervision: Ming-Xuan Cai, Bei-Dou Xi. Writing ± original draft: Lei Wang, Ying-Jun Li, Jin-Sheng Wang. Writing ± review & editing: Lei Wang

Study on association of working hours and occupational physical activity with the occurrence of coronary heart disease in a Chinese population

) Scales. (DOCX) S1 File. STROBE checklist. (DOCX) Author Contributions Conceptualization: Lian-Sheng Wang. Data curation: Hao-Jie Shi. Formal analysis: Hao-Jie Shi, Hao Wang. Funding acquisition: Lian ... -Sheng Wang. Investigation: Mohammad Reeaze Khurwolah. Methodology: Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Yang Yang. Project administration: Yao Ma. Resources: Mohammad Reeaze Khurwolah, Ya-Fei Li

Physiological and genomic features of a novel violacein-producing bacterium isolated from surface seawater

Strains JW1T and JW3, isolated from surface seawater of the Arabian Sea, were subjected to polyphasic taxonomic analysis. Cells of both strains were Gram-stain-negative, aerobic, and rod-shaped. They formed violet pigment and produced violacein. On the basis of 16S rRNA gene sequence analysis, strains JW1T and JW3 showed high 16S rRNA gene sequence similarity with...

Model-based optimization approaches for precision medicine: A case study in presynaptic dopamine overactivity

, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Blood pressure and expression of microRNAs in whole blood

Background Blood pressure (BP) is a complex, multifactorial clinical outcome driven by genetic susceptibility, behavioral choices, and environmental factors. Many molecular mechanisms have been proposed for the pathophysiology of high BP even as its prevalence continues to grow worldwide, increasing morbidity and marking it as a major public health concern. To address this, we...

Correction: Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses

Sisi Luo Jiaoling Huang Yanfang Zhang Tingting Zeng Sheng Wang Jiabo Liu Yaoshan Pang There is an error in the Funding section. The correct funding information is as follows: This work was supported by

Development of a GeXP-multiplex PCR assay for the simultaneous detection and differentiation of six cattle viruses

Foot-and-mouth disease virus (FMDV), Bluetongue virus (BTV), Vesicular stomatitis Virus (VSV), Bovine viral diarrheal (BVDV), Bovine rotavirus (BRV), and Bovine herpesvirus 1 (IBRV) are common cattle infectious viruses that cause a great economic loss every year in many parts of the world. A rapid and high-throughput GenomeLab Gene Expression Profiler (GeXP) analyzer-based...

A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork

Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats...

Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency

-E-194-045-MY3, MOST104-2627B-194-001, and MOST105-2627-M-194-001, grant recipient Prof. Feng-Sheng Wang. The funders had no role in study design, data collection and analysis, decision to publish, or

Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events

Background Minor ischemic stroke (MIS) represents a major global public health problem worldwide due to high incidence. The aim of this study was to investigate whether metabolic syndrome (MetS) is a strong risk for MIS and subsequent vascular events (SVE). Methods A retrospective cohort study was performed examining symptomatic MIS in a Chinese neurologic outpatient population...

Use of Myometrium as an Internal Reference for Endometrial and Cervical Cancer on Multiphase Contrast-Enhanced MRI

Background Myometrial smooth muscle is normally within the field of view for the gynecological imaging. This study aimed to investigate the use of normal myometrium as an internal reference for endometrial and cervical cancer during multiphase contrast-enhanced magnetic resonance imaging (MCE-MRI) and to explore whether this information regarding tumor enhancement relative to the...

The Ratio of Circulating Regulatory T Cells (Tregs)/Th17 Cells Is Associated with Acute Allograft Rejection in Liver Transplantation

CD4+CD25+FoxP3+ regulatory T cells (Tregs) and Th17 cells are known to be involved in the alloreactive responses in organ transplantation, but little is known about the relationship between Tregs and Th17 cells in the context of liver alloresponse. Here, we investigated whether the circulating Tregs/Th17 ratio is associated with acute allograft rejection in liver transplantation...

Wnt Signaling Cross-Talks with JH Signaling by Suppressing Met and gce Expression

Juvenile hormone (JH) plays key roles in controlling insect growth and metamorphosis. However, relatively little is known about the JH signaling pathways. Until recent years, increasing evidence has suggested that JH modulates the action of 20-hydroxyecdysone (20E) by regulating expression of broad (br), a 20E early response gene, through Met/Gce and Kr-h1. To identify other...

A Scheme to Optimize Flow Routing and Polling Switch Selection of Software Defined Networks

This paper aims at minimizing the communication cost for collecting flow information in Software Defined Networks (SDN). Since flow-based information collecting method requires too much communication cost, and switch-based method proposed recently cannot benefit from controlling flow routing, jointly optimize flow routing and polling switch selection is proposed to reduce the...

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4

Background Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and that its downregulation influences the activation of hepatic stellate cells (HSCs). In addition, inhibition of the activity of histone deacetylases 4 (HDAC4) has been shown to strongly reduce HSC activation in the context of liver fibrosis. Objectives In this study, we...

Effects of Computer Navigation versus Conventional Total Knee Arthroplasty on Endothelial Damage Marker Levels: A Prospective Comparative Study

Total knee arthroplasty (TKA) inevitably perturbs the femoral medullary canal, which increases blood loss or morbidities associated with marrow embolization postoperatively. Computer navigation TKA reportedly minimizes medullary disturbance to alleviate perioperative blood loss. We performed a prospective comparative study, enrolling 87 patients with osteoarthritic knees from...

Biogenesis of C-Glycosyl Flavones and Profiling of Flavonoid Glycosides in Lotus (Nelumbo nucifera)

Flavonoids in nine tissues of Nelumbo nucifera Gaertner were identified and quantified by high-performance liquid chromatography with diode array detector (HPLC-DAD) and HPLC-electrospray ionization-mass spectrometry (HPLC-ESI-MSn). Thirty-eight flavonoids were identified; eleven C-glycosides and five O-glycosides were discovered for the first time in N. nucifera. Most...

Mitigation of Oxidative Damage by Green Tea Polyphenols and Tai Chi Exercise in Postmenopausal Women with Osteopenia

Background Osteoporosis is a degenerative bone disease predominantly in postmenopausal women. Green tea polyphenols (GTP) and Tai Chi (TC) have been shown to be beneficial on human bone health. This study examined the efficacy of GTP and TC on mitigation of oxidative damage in postmenopausal women with osteopenia. Methods A 6-month randomized and placebo-controlled clinical trial...

MicroRNA Discovery and Analysis of Pinewood Nematode Bursaphelenchus xylophilus by Deep Sequencing

Background MicroRNAs (miRNAs) are considered to be very important in regulating the growth, development, behavior and stress response in animals and plants in post-transcriptional gene regulation. Pinewood nematode, Bursaphelenchus xylophilus, is an important invasive plant parasitic nematode in Asia. To have a comprehensive knowledge about miRNAs of the nematode is necessary for...