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Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis

metastasis. KeywordsHepatocellular carcinoma CD147 Phosphorylation Invasion Metastasis  Jin Jin and Shi-Jie Wang contributed equally to this work. Electronic supplementary material The online version of

CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma

Background The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigated the molecular mechanism underlying CD147 induced RhoA deactivation in hepatocellular carcinoma (HCC) cells. Methods Wound-healing assay was performed to study...

Antitumor effects and mechanisms of dendritic cells stimulated by sCD40L on ovarian cancer cells in vitro

Kang,1 Shi-jie Wang,4 Bao-en Shan21Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, 2Research Center, Fourth Hospital of Hebei Medical University, 3Department of