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A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining

Background Inflammation is a hallmark of many human diseases. Elucidating the mechanisms underlying systemic inflammation has long been an important topic in basic and clinical research. When primary pathogenetic events remains unclear due to its immense complexity, construction and analysis of the gene regulatory network of inflammation at times becomes the best way to...

Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNF╬▒-induced inflammatory responses

Shih-Kuang Yang 0 Yu-Chao Wang 0 Chun-Cheih Chao Yung-Jen Chuang Chung-Yu Lan Bor-Sen Chen 0 0 Laboratory of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua