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Search: authors:"Shing M. Lee"

3 papers found.
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Continual reassessment method with multiple toxicity constraints

This paper addresses the dose-finding problem in cancer trials in which we are concerned with the gradation of severe toxicities that are considered dose limiting. In order to differentiate the tolerance for different toxicity types and grades, we propose a novel extension of the continual reassessment method that explicitly accounts for multiple toxicity constraints. We apply...

Naltrexone Dampens Ethanol-Induced Cardiovascular and Hypothalamic-Pituitary-Adrenal Axis Activation

journals • PubMed • Google ScholarSearch for Shing M Lee in:Nature Research journals • PubMed • Google ScholarSearch for Charles A Rohde in:Nature Research journals • PubMed • Google Scholar Corresponding

Assessment of Plasma DNA Levels, Allelic Imbalance, and CA 125 as Diagnostic Tests for Cancer

Background: Allelic imbalance (AI), the loss or gain of chromosomal regions, is found in many cancers. AI can be detected in genomic tumor DNA released into the blood after necrosis or apoptosis. We evaluated plasma DNA concentration, allelic status in plasma DNA, and serum CA 125 level as screening tests for ovarian and other cancers. Methods: Plasma samples were obtained from...