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A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

, Daniel Ziemek at Pfizer. Lead authors of the SUMMIT consortium are MM () and LG (). Author Contributions Conceptualization: Shiro Maeda. Data curation: Atsushi Takahashi. Formal analysis: Makiko Taira ... , Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani. Funding acquisition: Toshimasa Yamauchi, Takashi Kadowaki, Shiro Maeda. Investigation: Makiko Taira, Minako Imamura, Shiro Maeda. Methodology: Shiro

Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies

Aim We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and six susceptibility loci (TMEM154, SSR1, FAF1, POU5F1, ARL15, and MPHOSPH9) originally identified by a transethnic meta-analysis of genome-wide association studies (GWAS) in 2014. Methods We genotyped 7,620 Japanese participants (5,817 type 2 diabetes patients and...

FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men

Aim Several studies have demonstrated that polymorphisms within the fat-mass and obesity-associated gene (FTO) are associated with type 2 diabetes (T2D). However, whether the effects of the FTO locus on T2D susceptibility are independent of fat-mass increases remains controversial. To investigate this issue, we examined the association of FTO variants with T2D and various aspects...

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes

Aim We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genome-wide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, and BCAR1. We also examined the association of 3 additional loci: CCND2 and GIPR, identified in sex-differentiated...

The Construction of Risk Prediction Models Using GWAS Data and Its Application to a Type 2 Diabetes Prospective Cohort

Hirakawa Toshiharu Ninomiya Yutaka Kiyohara Michiaki Kubo Yusuke Nakamura Shiro Maeda Tatsuhiko Tsunoda Zhi Wei, New Jersey Institute of Technology, United States of America Recent genome-wide association ... Interests: Dr. Shiro Maeda is a PLOS ONE Editorial Broad Member. This does not alter the authors adherence to all the PLOS ONE policies on sharing data and materials. No competing interests exist for the

Replication Study for the Association of 9 East Asian GWAS-Derived Loci with Susceptibility to Type 2 Diabetes in a Japanese Population

AimsEast Asian genome-wide association studies (GWAS) for type 2 diabetes identified 8 loci with genome-wide significance, and 2 loci with a borderline association. However, the associations of these loci except MAEA locus with type 2 diabetes have not been evaluated in independent East Asian cohorts. We performed a replication study to investigate the association of these...

A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population

Diabetes, and Obesity . N Engl J Med 363 : 2339 - 2350 . 4. Imamura M , Shiro Maeda ( 2011 ) Genetics of type 2 diabetes: the GWAS era and future perspectives . Endocr J 58 : 723 - 739 . 5. Sladek R

Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals


The Influence of a Single Nucleotide Polymorphism within CNDP1 on Susceptibility to Diabetic Nephropathy in Japanese Women with Type 2 Diabetes

Maeda 0 Yong-Gang Yao, Kunming Institute of Zoology, Chinese Academy of Sciences, China 0 1 Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine , Yokohama, Kanagawa , Japan , 2

Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese

Hiroshi Hirose Kohei Kaku Hiroshi Maegawa Hirotaka Watada Atsunori Kashiwagi Ryuzo Kawamori Kazuyuki Tobe Takashi Kadowaki Yusuke Nakamura Shiro Maeda Niyaz Ahmed, University of Hyderabad, India

Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes

Background Sirtuin is a member of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, and has been reported to play a pivotal role in energy expenditure, mitochondrial function and pathogenesis of metabolic diseases, including aging kidneys. In this study, we focused on the genes encoding sirtuin families, and examined the association between single nucleotide...

A Single Nucleotide Polymorphism in KCNQ1 Is Associated With Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes

NAKAMURA PHD SHIRO MAEDA PHD OBJECTIVE - Genetic factors have been considered to contribute to the development and progression of diabetic nephropathy. The KCNQ1 gene (potassium voltage-gated channel

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 With Susceptibility to Type 2 Diabetes in a Japanese Population

OBJECTIVE—Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome-wide association studies in white populations. To further investigate the involvement of these polymorphisms in conferring susceptibility to type 2 diabetes, we examined the association of 14 single nucleotide polymorphisms (SNPs) within 11 candidate loci with...

Identification of independent risk loci for Graves’ disease within the MHC in the Japanese population

Takahashi 10 Kenichiro Hata 7 Yasuo Takashima 6 11 Midori Koyanagi 6 11 Hirofumi Nakaoka 12 Takashi Akamizu 5 13 Naofumi Ishikawa 14 Sumihisa Kubota 15 Shiro Maeda 0 Tatsuhiko Tsunoda 1 Michiaki Kubo 2

Replication Study for the Association Between Four Loci Identified by a Genome-Wide Association Study on European American Subjects With Type 1 Diabetes and Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes

Shiro Maeda Shin-ichi Araki Tetsuya Babazono Masao Toyoda Tomoya Umezono Koichi Kawai Masahito Imanishi Takashi Uzu Hirotaka Watada Daisuke Suzuki Atsunori Kashiwagi Yasuhiko Iwamoto Kohei Kaku

The Type 2 Diabetes Associated Minor Allele of rs2237895 KCNQ1 Associates with Reduced Insulin Release Following an Oral Glucose Load

Background Polymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present study was to investigate the putative impact of these KCNQ1 polymorphisms (rs2283228, rs2237892, rs2237895, and rs2237897) on estimates of glucose stimulated insulin release...

Genome-wide association study identifies three novel loci for type 2 diabetes

Kamatani Michiaki Kubo Shiro Maeda Takashi Kadowaki 0 The Author 2013. Published by Oxford University Press. All rights reserved Although over 60 loci for type 2 diabetes (T2D) have been identified, there

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

journals • PubMed • Google ScholarSearch for Shiro Maeda in:Nature Research journals • PubMed • Google ScholarSearch for Takashi Kadowaki in:Nature Research journals • PubMed • Google Scholar Contributions S ... discovery. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Shiro Maeda or Takashi Kadowaki. Supplementary information PDF files1

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

Minako Imamura Shiro Maeda Toshimasa Yamauchi Kazuo Hara Kazuki Yasuda Takashi Morizono Atsushi Takahashi Momoko Horikoshi Masahiro Nakamura Hayato Fujita Tatsuhiko Tsunoda Michiaki Kubo Hirotaka

An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects

Pamela J. Hicks Kurt A. Langberg Meredith A. Bostrom Jessica N. Cooke Daisuke Suzuki Tetsuya Babazono Takashi Uzu Sydney C. W. Tang Ashis K. Mondal Neeraj K. Sharma Shiro Maeda John S. Parks Peter Kovacs