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92 papers found.
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A mathematical model of case-ascertainment bias: Applied to case-control studies nested within a randomized screening trial

integrity and validity of the data collected and analyzed. Author Contributions Conceptualization: Rick J. Jansen, Richard B. Hayes, Anthony B. Miller, Sholom Wacholder, Timothy R. Church. Formal analysis ... : Rick J. Jansen, Timothy R. Church. Funding acquisition: Timothy R. Church. Investigation: Rick J. Jansen, Bruce H. Alexander, Richard B. Hayes, Anthony B. Miller, Sholom Wacholder, Timothy R. Church

Time to First Morning Cigarette and Risk of Chronic Obstructive Pulmonary Disease: Smokers in the PLCO Cancer Screening Trial

Background Time to first cigarette (TTFC) after waking is an indicator of nicotine dependence. The association between TTFC and chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States, has not yet been reported. Methods We investigated the cross-sectional association between TTFC and prevalent COPD among 6,108 current smokers in the...

Invited Commentary: More Surprises From a Gene Desert

Sholom Wacholder 0 Meredith Yeager 0 Linda M. Liao 0 0 6120 Executive Boulevard , Suite 5050, MSC 7229, Rockville, MD 20852 ( Pleiotropy across the 8q24 region is perhaps the most intriguing of the ... , Bethesda, Maryland (Sholom Wacholder); National Cancer Institute, Core Genotyping Facility, SAIC-Frederick (Meredith Yeager); and Division of Cancer Epidemiology and Genetics, Occupational and Environmental

A prospective study of absolute risk and determinants of human papillomavirus incidence among young women in Costa Rica

), and Sholom Wacholder (Statistician); at SAIC, NCIFrederick, Frederick, MD: Ligia Pinto (Head, HPV Immunology Laboratory) and Alfonso Garcia-Pineres (Scientist, HPV Immunology Laboratory); at Womens and

Inference From a Multiplicative Model of Joint Genetic Effects for Ovarian Cancer Risk

0 6120 Executive Blvd. , EPS 5050, MSC-7244, Rockville, MD 20892-7244 ( 1 Sholom Wacholder , Summer S. Han , Clarice R. Weinberg 2 Affiliations of authors: Biostatistics Branch, Division of Cancer

Invited Commentary: Efficient Testing of Gene-Environment Interaction

Nilanjan Chatterjee Sholom Wacholder Gene-environment-wide interaction studies of disease occurrence in human populations may be able to exploit the same agnostic approach to interrogating the human ... of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Bethesda, Maryland (Nilanjan Chatterjee, Sholom Wacholder). This

Performance of Self-Collected Cervical Samples in Screening for Future Precancer Using Human Papillomavirus DNA Testing

coordinator), Mark Schiffman (medical monitor and NCI co-project officer), John T. Schiller (HPV virologist), Mark Sherman (QC pathologist), Diane Solomon (medical monitor and QC pathologist), Sholom Wacholder

Invited Commentary: From Genome-Wide Association Studies to Gene-Environment-Wide Interaction Studies—Challenges and Opportunities

The recent success of genome-wide association studies in finding susceptibility genes for many common diseases presents tremendous opportunities for epidemiologic studies of environmental risk factors. Analysis of gene-environment interactions, included in only a small fraction of epidemiologic studies until now, will begin to accelerate as investigators integrate analyses of...

A regression model for risk difference estimation in population-based case–control studies clarifies gender differences in lung cancer risk of smokers and never smokers

smokers Stephanie A Kovalchik 0 Sara De Matteis Maria Teresa Landi Neil E Caporaso Ravi Varadhan Dario Consonni Andrew W Bergen Hormuzd A Katki Sholom Wacholder 0 Economics, Sociology, and Statistics

A Flexible Bayesian Model for Studying Gene–Environment Interaction

An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence the disease risk. The standard approach to this study of gene–environment interaction considers one genetic marker at a time and...

Impact of Human Papillomavirus Vaccination on Cervical Cytology Screening, Colposcopy, and Treatment

of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland (Diane Solomon, Allan Hildesheim, Sholom Wacholder, Mark Schiffman); and Prevention and Implementation Group ... monitor and NCI co-Project Officer), John T. Schiller (HPV virologist), Mark Sherman (quality control pathologist), Diane Solomon (medical monitor and quality control pathologist), and Sholom Wacholder

Response: Re: Human Papillomavirus Testing in the Prevention of Cervical Cancer

limited, and the opportunities for benefit so great that all earnest approaches must be welcomed. MARK SCHIFFMAN NICOLAS WENTZENSEN SHOLOM WACHOLDER WALTER KINNEY JULIA C. GAGE PHILIP E. CASTLE

Human Papillomavirus Testing in the Prevention of Cervical Cancer

Mark Schiffman Nicolas Wentzensen Sholom Wacholder Walter Kinney Julia C. Gage Philip E. Castle Strong evidence now supports the adoption of cervical cancer prevention strategies that explicitly

Time to Smoke First Morning Cigarette and Lung Cancer in a Case–Control Study

Background Targeting smokers at higher lung cancer risk can improve efficiency and reduce false-positive detection in lung cancer screening. We evaluated whether time to first cigarette after waking (TTFC), a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics (intensity, duration, and pack-years).

A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection

Background Vaginal pH is related to genital tract inflammation and changes in the bacterial flora, both suggested cofactors for persistence of human papillomavirus (HPV) infection. To evaluate the relationship between vaginal pH and HPV, we analyzed data from our large population-based study in Guanacaste, Costa Rica. We examined vaginal pH and the risk of HPV infection...

Are Women Who Smoke at Higher Risk for Lung Cancer Than Men Who Smoke?

affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland (Sara De Matteis, Andrew W. Bergen, Neil E. Caporaso, Jay H. Lubin, Sholom Wacholder, Maria Teresa Landi