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A General Strategy for Nanohybrids Synthesis via Coupled Competitive Reactions Controlled in a Hybrid Process

, ChinaXiaomiao Shen, Xiaodi Zhong & Shuai Li AuthorsSearch for Rongming Wang in:Nature Research journals • PubMed • Google ScholarSearch for Wantai Yang in:Nature Research journals • PubMed • Google ScholarSearch ... • PubMed • Google ScholarSearch for Xiaodi Zhong in:Nature Research journals • PubMed • Google ScholarSearch for Shuai Li in:Nature Research journals • PubMed • Google ScholarSearch for Yujun Song in:Nature

A Novel Algorithm to Scheduling Optimization of Melting-Casting Process in Copper Alloy Strip Production

Melting-casting is the first process in copper alloy strip production. The schedule scheme on this process affects the subsequent processes greatly. In this paper, we build the multiobjective model of melting-casting scheduling problem, which considers minimizing the makespan and total weighted earliness and tardiness penalties comprehensively. A novel algorithm, which we called...

A Novel Algorithm to Scheduling Optimization of Melting-Casting Process in Copper Alloy Strip Production

Melting-casting is the first process in copper alloy strip production. The schedule scheme on this process affects the subsequent processes greatly. In this paper, we build the multiobjective model of melting-casting scheduling problem, which considers minimizing the makespan and total weighted earliness and tardiness penalties comprehensively. A novel algorithm, which we called...

A Novel Mouse Dscam Mutation Inhibits Localization and Shedding of DSCAM

The differential adhesion hypothesis of development states that patterning of organisms, organs and tissues is mediated in large part by expression of cell adhesion molecules. The cues provided by cell adhesion molecules are also hypothesized to facilitate specific connectivity within the nervous system. In this study we characterize a novel mouse mutation in the gene Dscam (Down...

ASD v2.0: updated content and novel features focusing on allosteric regulation

Allostery is the most direct and efficient way for regulation of biological macromolecule function and is induced by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site. AlloSteric Database (ASD, http://mdl.shsmu.edu.cn/ASD) has been developed to provide comprehensive information on allostery. Owing to the inherent high receptor...

ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks

Allosteric regulation, the most direct and efficient way of regulating protein function, is induced by the binding of a ligand at one site that is topographically distinct from an orthosteric site. Allosteric Database (ASD, available online at http://mdl.shsmu.edu.cn/ASD) has been developed to provide comprehensive information featuring allosteric regulation. With increasing data...

Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway

G503 is an anthraquinone compound isolated from the secondary metabolites of a mangrove endophytic fungus from the South China Sea. The present study elucidates the anti-tumor activity and the underlying mechanism of G503. Cell viability assay performed in nine cancer cell lines and two normal cell lines demonstrated that the gastric cancer cell line SGC7901 is the most G503...

Bortezomib, a Proteasome Inhibitor, Attenuates Angiotensin II-Induced Hypertension and Aortic Remodeling in Rats

Background Hypertension is a highly prevalent disorder and a major risk factor for cardiovascular diseases. Hypertensive vascular remodeling is the pathological mal-adaption of blood vessels to the hypertensive condition that contributes to further development of high blood pressure and end-organ damage. Hypertensive remodeling involves, at least in part, changes in protein...

Calibur: a tool for clustering large numbers of protein decoys

Background Ab initio protein structure prediction methods generate numerous structural candidates, which are referred to as decoys. The decoy with the most number of neighbors of up to a threshold distance is typically identified as the most representative decoy. However, the clustering of decoys needed for this criterion involves computations with runtimes that are at best...

Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

BackgroundSmoking has been reported to be associated with peripheral blood DNA methylation, but the causal aspects of the association have rarely been investigated. We aimed to investigate the association and underlying causation between smoking and blood methylation.MethodsThe methylation profile of DNA from the peripheral blood, collected as dried blood spots stored on Guthrie...

Cervical Spine Mechanism for Reproduction of the Biomechanical Behaviours of the Human Neck during Rotation-Traction Manipulation

Rotation-traction (RT) manipulation is a commonly used physical therapy procedure in TCM (traditional Chinese medicine) for cervical spondylosis. This procedure temporarily separates the C3 and C4 cervical vertebrae from each other when a physician applies a jerky action while the neck is voluntarily turned by the patient to a specific position as instructed by the physician...

Changes in apoptotic microRNA and mRNA expression profiling in Caenorhabditis elegans during the Shenzhou-8 mission

Radiation and microgravity exposure have been proven to induce abnormal apoptosis in microRNA (miRNA) and mRNA expression, but whether space conditions, including radiation and microgravity, activate miRNAs to regulate the apoptosis is undetermined. For that purpose, we investigated miRNome and mRNA expression in the ced-1 Caenorhabditis elegans mutant vs the wild-type, both of...

Characterization of Small Interfering RNAs Derived from Sugarcane Mosaic Virus in Infected Maize Plants by Deep Sequencing

RNA silencing is a conserved surveillance mechanism against viruses in plants. It is mediated by Dicer-like (DCL) proteins producing small interfering RNAs (siRNAs), which guide specific Argonaute (AGO)-containing complexes to inactivate viral genomes and may promote the silencing of host mRNAs. In this study, we obtained the profile of virus-derived siRNAs (vsiRNAs) from...

Clinicopathological Features and Prognosis of Metaplastic Breast Carcinoma: Experience of a Major Chinese Cancer Center

Metaplastic breast carcinoma (MBC) is a rare heterogeneous group of primary breast malignancies, with low hormone receptor expression and poor outcomes. To date, no prognostic markers for this tumor have been validated. The current study was undertaken to evaluate the clinicopathologic characteristics, the response to various therapeutic regimens and the prognosis of MBCs in a...

Coordinated Parameter Identification Technique for the Inertial Parameters of Non-Cooperative Target

Space operations will be the main space missions in the future. This paper focuses on the precise operations for non-cooperative target, and researches of coordinated parameter identification (CPI) which allows the motion of multi-joints. The contents of this paper are organized: (1) Summarize the inertial parameters identification techniques which have been conducted now, and...

Correction to: miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a

The original article [1] contains an error in Fig. 5a whereby the Western blot bands representing CyclinD1 have mistakenly been duplicated over the Western blot bands intended to represent SGK.

Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia

Several cell types are considered to be effector cells in bile duct injury in rhesus rotavirus (RRV)-induced experimental biliary atresia (BA). Here, we identified an increased T helper 17 (Th17) cell population in a BA mode. By depleting the Th17 cells, the BA symptoms (onset of jaundice, acholic stools and retarded growth) were attenuated and the survival rate was improved...

Design of Flow Big Data System Based on Smart Pipeline Theory

As telecom operators to build intelligent pipe more and more, analysis and processing of big data technology to deal the huge amounts of data intelligent pipeline generated has become an inevitable trend. Intelligent pipe describes operational data, sales data; operator’s pipe flow data make the value for e-commerce business form and business model in mobile e-business...

Development of Novel Biocomposite Scaffold of Chitosan-Gelatin/Nanohydroxyapatite for Potential Bone Tissue Engineering Applications

In this study, a three-dimensional chitosan-gelatin/nanohydroxyapatite (ChG/nHaP) scaffold was successfully fabricated and characterized in terms of swelling, degradation, cell proliferation, cell attachment, and mineralization characterizations. The ChG/nHaP scaffold was fabricated with a mean pore size of 100–180 μm. Our results showed that the physicochemical and biological...

Effect of Anionic Polyacrylamide on the Structural Stability of Thickened Tailings Slurry in Pipeline Transportation

, Changsha 410083, China 3Department of Personnel, Guangxi University of Science and Technology, Liuzhou 545006, China Correspondence should be addressed to Shuai Li; moc.361@02462800251 Received 18 December