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Formononetin Enhances the Tumoricidal Effect of Everolimus in Breast Cancer MDA-MB-468 Cells by Suppressing the mTOR Pathway

Yuan,2 and Desheng Fan3 1Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2Breast Surgery Department, Baoshan

Highly extended filaments in aqueous gold nano-particle colloidals

A new regime of filamentation has been discovered in aqueous gold nanoparticle colloidals (AGNC). Different from filamentation in liquids, in this regime, by doping water with gold nanoparticles, there is no observable multiple small-scale filaments, but instead a spatially continuous plasma channel is formed. The length of the filament is more than ten times as compared with...

A New Smart Surface-Enhanced Raman Scattering Sensor Based on pH-Responsive Polyacryloyl Hydrazine Capped Ag Nanoparticles

A novel pH-responsive Ag@polyacryloyl hydrazide (Ag@PAH) nanoparticle for the first time as a surface-enhanced Raman scattering (SERS) substrate was prepared without reducing agent and end-capping reagent. Ag@PAH nanoparticles exhibited an excellent tunable detecting performance in the range from pH = 4 to pH = 9. This is explained that the swelling-shrinking behavior of...

Speech Denoising in White Noise Based on Signal Subspace Low-rank Plus Sparse Decomposition

In this paper, a new subspace speech enhancement method using low-rank and sparse decomposition is presented. In the proposed method, we firstly structure the corrupted data as a Toeplitz matrix and estimate its effective rank for the underlying human speech signal. Then the low-rank and sparse decomposition is performed with the guidance of speech rank value to remove the noise...

Recognition of Aircraft Engine Sound Based on GMM-UBM Model

Gaussian mixture model-universal background model (GMM-UBM) is a commonly-used speaker recognition technology, and which has achieved good effect for detection speaker’s sound. In this paper, we explore GMM-UBM method for use with abnormal aircraft engine sound detection. We designed a GMM-UBM based aircraft engine sound recognition system, which extracts MFCC feature parameters...

Comparative efficacy and acceptability of bibliotherapy for depression and anxiety disorders in children and adolescents: a meta-analysis of randomized clinical trials

Comparative efficacy and acceptability of bibliotherapy for depression and anxiety disorders in children and adolescents: a meta-analysis of randomized clinical trials Shuai Yuan,1,* Xinyu Zhou,1,2 ... comments 2 Editor who approved publication: Professor Wai Kwong Tang Shuai Yuan,1,* Xinyu Zhou,1,2,* Yuqing Zhang,1,3,* Hanpin Zhang,1,3,* Juncai Pu,1,3 Lining Yang,1,3 Lanxiang Liu

Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression

Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28–30 rats were included in each model of depression (chronic unpredictable mild stress...

Full Vehicle Vibration and Noise Analysis Based on Substructure Power Flow

Engineering Institute, Guangzhou Automobile Group Co., Ltd., Guangzhou 511434, China Correspondence should be addressed to Shuai Yuan; moc.qq@043987024 Received 30 November 2016; Revised 6 March 2017

Long non-coding RNA MUC5B-AS1 promotes metastasis through mutually regulating MUC5B expression in lung adenocarcinoma

Long non-coding RNAs (lncRNAs) have been involved in the process of cancer occurrence, progression, and treatment. Lung cancer-related lncRNAs are still an emerging field, thus we sought to identify novel functional lncRNAs as candidate targets in lung cancer. Here, we identified one novel lncRNA, MUC5B-AS1 (Ensembl: ENST00000532061.2). MUC5B-AS1 was upregulated in lung...

Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents

Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma samples based on ultra-high-performance liquid chromatography equipped with quadrupole time-offlight mass spectrometry to...

The study of statistical methods for evaluating the comparability of routine chemistry analytes among 3 routine laboratory measurement systems in China

Chuanbao Zhang Falin He Shuai Yuan Zhiguo Wang Background: Clinical laboratory tests are important for clinicians to make diagnostic decisions, but discrepancies may directly lead to incorrect diagnosis. We

Epidemiological and molecular characterization of dengue viruses imported into Guangzhou during 2009–2013

Background Dengue virus causes one of the most significant infectious diseases in tropical and subtropical regions, notable number of which is imported into China every year. Results In this study, the molecular epidemiologic and phylogenetic analyses of dengue cases imported into Guangzhou in South China during 2009–2013 were conducted. During that period, 46 imported dengue...

Morphologic and Molecular Characterization of a Strain of Zika Virus Imported into Guangdong, China

no conflict of interest. Author Xiaobo Li declares that he has no conflict of interest. Author Shuai Yuan declares that she has no conflict of interest. Author Ling Chen declares that he has no

Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells

Central Universities. Author information AffiliationsDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USAJinshun Xu, Shuai Yuan, Ting Si & Ronald X. XuChongqing Key ... Research journals • PubMed • Google ScholarSearch for Shuai Yuan in:Nature Research journals • PubMed • Google ScholarSearch for Jilai Tian in:Nature Research journals • PubMed • Google ScholarSearch for

Emerging issues for education in E-discovery for electronic health records

In order to provide a foundation for education on e-discovery and security in Electronic Health Record (EHR) systems, this paper identifies emerging issues in the area. Based on a detailed literature review it details key categories: Development in EHR, E-discovery policy and strategy, and Security and privacy in EHR and also discusses e-discovery issues in cloud computing and...

Analysis of Early Postoperative Pain in the First and Second Knee in Staged Bilateral Total Knee Arthroplasty: A Retrospective Controlled Study

Objective A retrospective analysis of early postoperative pain in the first and second knee in staged bilateral total knee arthroplasty (TKA) to provide a clinical evidence for the change of analgesic strategy. Methods From January 2009 to January 2013, 87 cases which meet the inclusion criterion were retrospectively reviewed. In stage TKA, the postoperative pain in the first and...

Combined effects of fruit and vegetables intake and physical activity on the risk of metabolic syndrome among Chinese adults

MetS. Author Contributions Conceptualization: Qi-qiang He. Data curation: Xin-tong Li, Wei Liao. Formal analysis: Xin-tong Li, Wei Liao, Hong-jie Yu, Ming-wei Liu, Shuai Yuan, Bo-wen Tang ... . Methodology: Xin-tong Li, Wei Liao, Hong-jie Yu, Ming-wei Liu, Shuai Yuan, Bo-wen Tang, Xu-hao Yang, Yong Song, Samuel D. Towne, Jr. Project administration: Zong-fu Mao, Qi-qiang He. Resources: Shi-le Cheng

Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute

The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages...

Coaxial Electrospray of Curcumin-Loaded Microparticles for Sustained Drug Release

Curcumin exhibits superior anti-inflammatory, antiseptic and analgesic activities without significant side effects. However, clinical dissemination of this natural medicine is limited by its low solubility and poor bio-availability. To overcome this limitation, we propose to encapsulate curcumin in poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) by an improved coaxial...