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The Nox1/Nox4 inhibitor attenuates acute lung injury induced by ischemia-reperfusion in mice

. Writing ? review & editing: Gen Li, Xiao-shuang Zhou, Bin Liu. 13 / 15 14 / 15 1. Gielis JF , Beckers PAJ , Briede JJ , Cos P , Van Schil PE. Oxidative and nitrosative stress during pulmonary ischemia ... Wang, Bin Liu. Data curation: Gen Li, Wan Ma, Bin Liu. Formal analysis: Jia Wang. Funding acquisition: Bin Liu. Methodology: Yu Cui, Yu Wang, Jia Wang. Project administration: Yu Wang, Xiao-shuang

Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method

A risk assessment of deoxynivalenol (DON) was recently conducted for the residents in Henan province, China, where wheat as the staple food are highly consumed. A high-throughput sensitive UPLC-MS/MS method following 96-well μElution solid-phase extraction (SPE) were developed and validated for the determination of DON biomarkers in human urine. Isotope labelled internal standard...

Fine structure of the topological defect cores studied for disclinations in lyotropic chromonic liquid crystals

The detailed structure of singularities of ordered field represents a fundamental problem in diverse areas of physics. At the defect cores, the deformations are so strong that the system explores states with symmetry different from that of an undistorted material. These regions are difficult to explore experimentally as their spatial extension is very small, a few molecular...

Electroacupuncture Ameliorates Cerebral Ischemia-Reperfusion Injury by Regulation of Autophagy and Apoptosis

Qian participated in the statistical analysis. Shuang Zhou participated in the design of the study and Chang-quan Ling reviewed the study and supervised the experiments. All authors read and approved the

Sharp power-type Heronian mean bounds for the Sándor and Yang means

We prove that the double inequalities H α ( a , b ) < X ( a , b ) < H β ( a , b ) and H λ ( a , b ) < U ( a , b ) < H μ ( a , b ) hold for all a , b > 0 with a ≠ b if and only if α ≤ 1 / 2 , β ≥ log 3 / ( 1 + log 2 ) = 0.6488 ⋯ , λ ≤ 2 log 3 / ( 2 log π − log 2 ) = 1.3764 ⋯ , and μ ≥ 2 , where H p ( a , b ) , X ( a , b ) , and U ( a , b ) are, respectively, the pth power-type...

An Improved Feature Selection Based on Effective Range for Classification

Feature selection is a key issue in the domain of machine learning and related fields. The results of feature selection can directly affect the classifier’s classification accuracy and generalization performance. Recently, a statistical feature selection method named effective range based gene selection (ERGS) is proposed. However, ERGS only considers the overlapping area (OA...

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

University of Hong Kong and Hong Kong Scholar Program. Author information Author notesPatrick Ming-Kuen Tang, Shuang Zhou & Xiao-Ming Meng These authors contributed equally to this work ... Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR 999077, ChinaPatrick Ming-Kuen Tang, Shuang Zhou, Xiao-Ming Meng, Qing-Ming Wang, Chun-Jie Li, Guang-Yu Lian, Xiao-Ru

Wrist-ankle acupuncture (WAA) for precompetition nervous syndrome: study protocol for a randomized controlled trial

Cheng-lin Zhou 0 Shuang Zhou 1 0 Department of Sport Psychology, School of Kinesiology, Shanghai University of Sport , 399, Changhai Road, Yangpu District, Shanghai 200433 , China 1 Changhai Hospital of

Depletion of CD4+ CD25+ Regulatory T Cells Promotes CCL21-Mediated Antitumor Immunity

CCL21 is known to attract dendritic cells (DCs) and T cells that may reverse tumor-mediated immune suppression. The massive infiltration of tumors by regulatory T cells (Tregs) prevents the development of a successful helper immune response. In this study, we investigated whether elimination of CD4+ CD25+ Tregs in the tumor microenvironment using anti-CD25 monoclonal antibodies...

CCR7 Expression and Intratumoral FOXP3+ Regulatory T Cells are Correlated with Overall Survival and Lymph Node Metastasis in Gastric Cancer

investigator (to Dr. Shuang Zhou) and Hong Kong Scholar program (No. XJ2011025). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

The anti-tumor effect and increased tregs infiltration mediated by rAAV-SLC vector

To explore the anti-tumor effect and immune mechanism mediated by a new recombinant adeno-associated virus (rAAV) encoding secondary lymphoid tissue chemokine (SLC) mature peptide gene. AAV Helper-Free system was used for rAAV-SLC package. The anti-tumor effect of SLC was detected by bearing tumor established from Hepal-6 cells both in C57BL/6J and nude mice. Flow cytometry...

Combination Therapy of VEGF-Trap and Gemcitabine Results in Improved Anti-Tumor Efficacy in a Mouse Lung Cancer Model

. 10140900400), National Natural Science Foundation of China (No. 31000527), Shanghai Health Bureau Research Fund for young investigator (to Dr. Shuang Zhou) and Hong Kong Scholar program (No. XJ2011025). The

Resveratrol Possesses Protective Effects in a Pristane-Induced Lupus Mouse Model

Background Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of autoantibodies. To date, no therapy has been found to satisfactorily treat SLE. SIRT1 deficiency results in the development of an autoimmune syndrome in mice, including a high titer of anti-nuclear antibody in serum, immunoglobulin deposition in the kidney, and...

Transgenic Bt Rice Does Not Challenge Host Preference of the Target Pest of Rice Leaffolder, Cnaphalocrocis medinalis (Lepidoptera: Pyralidae)

Background Transgenic Bt rice line T2A-1 expresses a synthesized cry2A gene that shows high resistance to Lepidoptera pests, including Cnaphalocrocis medinalis (Guenée) (Lepidoptera: Pyralidae). Plant volatile orientation cues and the physical characteristics of the leaf surface play key roles in host location or host-plant acceptance of phytophagous insects. These volatile...

Normalized Born Approximation-Based Two-Stage Reconstruction Algorithm for Quantitative Fluorescence Molecular Tomography

Fluorescence molecular tomography (FMT) is a promising technique for in vivo small animal imaging. In this paper, a two-stage reconstruction method based on normalized Born approximation is developed for FMT, which includes two steps for quantitative reconstruction. First, the localization of fluorescent fluorophore is determined by -norm regularization method. Then, in the...

Normalized Born Approximation-Based Two-Stage Reconstruction Algorithm for Quantitative Fluorescence Molecular Tomography

Fluorescence molecular tomography (FMT) is a promising technique for in vivo small animal imaging. In this paper, a two-stage reconstruction method based on normalized Born approximation is developed for FMT, which includes two steps for quantitative reconstruction. First, the localization of fluorescent fluorophore is determined by -norm regularization method. Then, in the...

Normalized Born Approximation-Based Two-Stage Reconstruction Algorithm for Quantitative Fluorescence Molecular Tomography

Fluorescence molecular tomography (FMT) is a promising technique for in vivo small animal imaging. In this paper, a two-stage reconstruction method based on normalized Born approximation is developed for FMT, which includes two steps for quantitative reconstruction. First, the localization of fluorescent fluorophore is determined by -norm regularization method. Then, in the...

Effects of Moxibustion Stimulation on the Intensity of Infrared Radiation of Tianshu (ST25) Acupoints in Rats with Ulcerative Colitis

ST25 is a key acupoint used in the treatment of ulcerative colitis by moxibustion stimulation, but the biophysical mechanism underlying its effects is still unknown. The aim of the present study was to explore the biophysical properties of ST25 acupoint stimulated by moxibustion in a rat model of ulcerative colitis. The infrared radiation intensity of fourteen wavelengths of ST25...

Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma

Background Secondary lymphoid tissue chemokine (SLC) is a key CC chemokine for chemotaxis of immune cells and has been an attractive candidate for anti-tumor treatments. However, among the immune cells recruited by SLC to tumors, the CD25+ Foxp3+ regulatory T cells (Tregs) compromise the anti-tumor effects. In this study, we proposed the combination therapy of intratumoral co...

High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR

Multiple lines of evidence suggest that a large portion of pancreatic cancer patients suffer from either hyperglycemia or diabetes, both of which are characterized by high blood glucose level. However, the underlying biological mechanism of this phenomenon is largely unknown. In the present study, we demonstrated that the proliferative ability of two human pancreatic cancer cell...