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Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair

Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting chondrocytes from hypertrophic differentiation during the process of endochondral ossification has been demonstrated. However, application of PTHrP in cartilage repair has not been extensively considered. This...

Holographic detection of AIS real-time signals based on sparse representation

To use the existing Automatic Identification System (AIS) shore stations for positioning so that the AIS can be used as an additional land-based positioning system for coastal vessels is a cutting-edge research topic, responding to the call of the International Maritime Organization (IMO). In order to use the ship-borne AIS for positioning function, a holographic detection of AIS...

A novel sparse representation algorithm for AIS real-time signals

Sparse representation of signals based on a redundant dictionary is a new signal representation theory. Recent research activities in this field have concentrated mainly on the study of dictionary design and sparse decomposition algorithms. Currently, the application of sparse representation on an Automatic Identification System (AIS) signal still requires further investigations...

Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells

Background Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce anti-tumor immune responses. In the current study, we aim to investigate the regulatory effect of the epigenetic drug MS-275 on hepatoma G2 (HepG2) cell-derived exosomes, especially for their immunostimulatory properties and alteration of some non-specific immune protein...

The Role of Macrophages in the Pathogenesis of ALI/ARDS

), the Medical and Health Research Program of Zhejiang Province (Core Talents Plan; no. 2016RCA014, Gensheng Zhang), and the Medical and Health Research Program of Zhejiang Province (no. 2018KY094, Shufang ... Zhang). References L. B. Ware and M. A. Matthay, “The acute respiratory distress syndrome,” New England Journal of Medicine, vol. 342, no. 18, pp. 1334–1349, 2000. View at Publisher · View at Google

A Protective Role of Glibenclamide in Inflammation-Associated Injury

glibenclamide to clinical application in inflammatory diseases. Conflicts of Interest The authors declare they have no competing interests. Authors’ Contributions Gensheng Zhang, Xiuhui Lin, and Shufang Zhang ... Research Program of Hangzhou (Grant no. 20140633B27, Shufang Zhang). References A. Marble, “Glibenclamide, a new sulphonylurea: whither oral hypoglycaemic agents?” Drugs, vol. 1, no. 2, pp. 109–115, 1971

Kazakhstan can achieve ambitious HIV targets despite expected donor withdrawal by combining improved ART procurement mechanisms with allocative and implementation efficiencies

Background Despite a non-decreasing HIV epidemic, international donors are soon expected to withdraw funding from Kazakhstan. Here we analyze how allocative, implementation, and technical efficiencies could strengthen the national HIV response under assumptions of future budget levels. Methodology We used the Optima model to project future scenarios of the HIV epidemic in...

Disparity and Convergence: Chinese Provincial Government Health Expenditures

The huge regional disparity in government health expenditures (GHE) is a major policy concern in China. This paper addresses whether provincial GHE converges in China from 1997 to 2009 using the economic convergence framework based on neoclassical economic growth theory. Our empirical investigation provides compelling evidence of long-term convergence in provincial GHE within...

Transcriptome Profiling of a Multiple Recurrent Muscle-Invasive Urothelial Carcinoma of the Bladder by Deep Sequencing

Urothelial carcinoma of the bladder (UCB) is one of the commonly diagnosed cancers in the world. The UCB has the highest rate of recurrence of any malignancy. A genome-wide screening of transcriptome dysregulation between cancer and normal tissue would provide insight into the molecular basis of UCB recurrence and is a key step to discovering biomarkers for diagnosis and...

A Gelatin-sulfonated Silk Composite Scaffold based on 3D Printing Technology Enhances Skin Regeneration by Stimulating Epidermal Growth and Dermal Neovascularization

, Quan Wang, Heng Sun, Varitsara Bunpetch, Shufang Zhang & Hongwei OuyangZhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou, ChinaSi Xiong, Xianzhu Zhang, Ping Lu ... , Yan Wu, Quan Wang, Heng Sun, Varitsara Bunpetch, Shufang Zhang & Hongwei OuyangUniversity of Hong Kong, Faculty of Dentistry, Pokfulam, Hong Kong SAR, ChinaBoon Chin HengState Key Laboratory for

High fever and multi-nodular lung consolidations after whole lung lavage in a patient with pulmonary alveolar proteinosis

Introduction Whole lung lavage is the most effective method to treat pulmonary alveolar proteinosis (PAP), and most potential complications occur often during the lavage process, but few happen after lavage. Theoretically, pulmonary edema would be more common after whole lung lavage. However, no such case was reported in the literature. Case description A 47-year-old Chinese male...

Empyema, acute respiratory failure, and septic shock after aspiration of a soft-shelled turtle (Pelodiscus sinensis) bone by an adult

Introduction The common late complications of foreign body aspiration include granulation formation, obstructive pneumonia, and atelectasis. However, a foreign body-induced pleural infection is very rare, and especially when it is not iatrogenic. Case description A 64-year-old Chinese man was admitted to our hospital with septic shock and acute respiratory failure requiring...

Gene silencing of heparanase results in suppression of invasion and migration of hepatoma cells

Background This study investigated the effect of transcriptional gene silencing (TGS) of the heparanase gene on hepatoma SMCC-7721 cells. Methods SiRNAs targeting the promoter region and coding region of the heparanase gene were designed and synthesized. Then the siRNAs were transfected into hepatoma SMCC-7721 cells by nuclear transfection or cytoplasmic transfection. The...