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16 papers found.
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Hydrogen Peroxide–Inducible Clone-5 Regulates Mesangial Cell Proliferation in Proliferative Glomerulonephritis in Mice

Hydrogen peroxide-inducible clone-5 (Hic-5) is a transforming growth factor (TGF)-β1-inducible focal adhesion protein. We previously demonstrated that Hic-5 was localized in mesangial cells and its expression was associated with glomerular cell proliferation and matrix expansion in human and rat glomerulonephritis (GN). In the present study, we first assessed the role of Hic-5 in...

Evidence-based clinical practice guidelines for IgA nephropathy 2014

2014. Committee chairman: Yukio Yuzawa. Committee members: Maki Urushihara, Shoji Kagami, Ritsuko Katafuchi, Hiroshi Kitamura, Hiroyuki Komatsu, Masashi Goto, Shuji Kondo, Mitsuhiro Sato, Kazuo Takahashi

The First Nationwide Survey and Genetic Analyses of Bardet-Biedl Syndrome in Japan

Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder characterized by central obesity, mental impairment, rod-cone dystrophy, polydactyly, hypogonadism in males, and renal abnormalities. The causative genes have been identified as BBS1-19. In Western countries, this disease is often reported, but remains undiagnosed in many patients until later in life, while only a few...

A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection

Infantile systemic lupus erythematosus (iSLE) is extremely rare. Patients with iSLE usually become severely unwell and have poor prognosis. Epstein–Barr virus (EBV) infection has been implicated in the development of SLE in both adults and children. Recently, we experienced a case of iSLE with severe lupus nephritis (LN) and EBV infection. A 14-month-old Japanese boy was...

Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy

Enhanced intrarenal renin-angiotensin system (RAS) is implicated in the development and progression of renal injury. To investigate whether angiotensinogen (AGT) expression is involved in glomerular RAS activity and glomerular injury, we examined glomerular AGT expression and its correlation with expression of other RAS components, and levels of glomerular injury in samples from...

Associations between headache and stress, alcohol drinking, exercise, sleep, and comorbid health conditions in a Japanese population

We conducted a cross-sectional survey of 12,988 subjects aged 20–79 years (5,908 men and 7,090 women) receiving health checkups at a Tokyo clinic. They filled out a self-administered structured questionnaire, and 5.4% of the men and 15.4% of the women reported having headaches. Younger subjects were more prone to having headaches. The likelihood of having headaches increased with...

Role of integrin-linked kinase in epithelial–mesenchymal transition in crescent formation of experimental glomerulonephritis

Background. Glomerular parietal epithelial–mesenchymal transition (EMT) is a key event in crescent formation of glomerulonephritis (GN). Integrin-linked kinase (ILK) is an integrin cytoplasmic-binding protein that has been implicated in the regulation of cell adhesion, extracellular matrix organization and EMT. Transforming growth factor-β (TGF-β) is involved in the induction and...

Big Mitogen-Activated Protein Kinase 1 (BMK1)/Extracellular Signal Regulated Kinase 5 (ERK5) Is Involved in Platelet-Derived Growth Factor (PDGF)−Induced Vascular Smooth Muscle Cell Migration

Cell Migration Yuki IZAWA Masanori YOSHIZUMI Keisuke ISHIZAWA Yoshiko FUJITA Shuji KONDO Shoji KAGAMI Kazuyoshi KAWAZOE Koichiro TSUCHIYA Shuhei TOMITA Toshiaki TAMAKI Big mitogen-activated protein

Synthesis of Polystyrene and Poly(methyl methacrylate) Each with a Phenyl Seleno Group at Terminal Chain End by Radical Polymerization in the Presence of Benzyl Phenyl Selenide as a Photoiniferter

The photopolymerization of styrene with benzyl phenyl selenide proceeded smoothly to give polystyrene having benzyl and phenylseleno groups at α- and ω-chain ends, respectively, and the degree of functionality was 0.95. In a limited range of conversion, both the polymer yields and number average of molecular weights (M̄n) increased with the reaction time and the M̄n linearly...

Side-Chain Crystallization of Comb-Like Copolymers Obtained from Isopropenyltriazines with Comonomers Having Octadecyl Group

Copolymerizations of 2-amino-4-anilino-6-isopropenyl-1,3,5-triazine and 2-amino-4-(N-octadecylanilino)-6-isopropenyl-1,3,5-triazine with octadecyl acrylate, octadecyl methacrylate, N-octadecylacrylamide, and N-octadecylmethacrylamide were carried out in order to investigate the side-chain crystallization of the resulting comb-like copolymers. Crystallization exothermic and...

Graft Copolymerization of Polydimethylsiloxane Macromonomers with Isopropenyl-1,3,5-triazines

Polydimethylsiloxane macromonomers (M1) having various molecular weights were copolymerized with two isopropenyltriazines (M2), 2-amino-4-anilino- and 4-(N-octadecylanilino)-6-isopropenyl-1,3,5-triazine (AAIT and N18), using azobisisobutyronitrile as an initiator in tetrahydrofuran. r1 decreased from 0.50 to 0.10 and r2 increased from 1.97 to 6.47 with the molecular weight of...

Synthesis of New Polyguanamine Macromonomers by Self-Polyaddition and Their Copolymerization

Polyguanamine macromonomers were synthesized by self-polyaddition reaction of 2-amino-4-(m-amino-N-alkylanilino)-6-isopropenyl-1,3,5-triazines. Alkyl groups were ethyl and octadecyl. Molecular weight of the macromonomers was determined to be 3000–4000 (number average molecular weight) by their 1H NMR spectra and gel permeation chromatography. Copolymerizations of the...

Synthesis and Characterization of New Comb-Like Polyguanamines Containing Three Long Alkyl Side-Chains in Repeating Unit

Novel comb-like poly(amide-guanamine)s, poly(urea-guanamine)s and poly-(imide-guanamine)s which contain three long alkyl side-chains in each repeating unit (three side-chains polymers), were synthesized by the reaction of 2,4-bis(amino-N-octadecylanilino)-6-heptadecyl-1,3,5-triazines with aromatic or aliphatic diacid chlorides, diisocyanates and pyromellitic dianhydride...

Synthesis and Side-Chain Crystallization of Comb-Like Polymers from Isopropenyltriazines Containing Several Long Alkyl Groups

2-Octadecylamino-4-(N-octadecylanilino)-6-isopropenyl-1,3,5-triazine (2N18) and 2-dioctadecylamino-4-(N-octadecylanilino)-6-isopropenyl-1,3,5-triazine (3N18) were prepared from 2-amino-4-(N-octadecylanilino)-6-isopropenyl-1,3,5-triazine (N18) with octadecyl bromide in the presence of sodium hydride. In the polymerization of these monomers, the polymer yield decreased with...

Synthesis and Characterization of New Comb-Like Aromatic Polyamides, Polyimides, and Polyureas Containing 1,3,5-Triazine Rings in their Side Chains

New comb-like aromatic polyamides, polyimides, and polyureas containing the 1,3,5-triazine ring with two long alkyl groups in the side chain (DA18-polymers) were synthesized by the reaction of m-phenylene diamine derivative, that is, 2,4-bis(N-octadecylanilino)-6-(3,5-diaminophenyl)-1,3,5-triazine (DA18) with aromatic diacid chlorides, pyromellitic dianhydride, and diisocyanates...