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Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

Limited efficacy of current antivirals and antiviral-resistant mutations impairs anti-influenza treatment. Here, we evaluate the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Viral replication is significantly reduced in cell lines transfected with DIG-3. Mice treated with DIG-3 encoded by jetPEI-vector, as prophylaxis and...

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses

information AffiliationsDepartment of Microbiology, The University of Hong Kong, Hong Kong, ChinaLei Wen, Hin Chu, Dong Wang, Cun Li, Xiaoyu Zhao, Man-Chun Chiu, Shuofeng Yuan, Honglin Chen, Jie Zhou & Kwok ... journals • PubMed • Google Scholar Search for Shuofeng Yuan in:Nature Research journals • PubMed • Google Scholar Search for Yanhui Fan in:Nature Research journals • PubMed • Google Scholar Search for

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways potential therapeutic targets. Here, by exploring a lipid library, we show that AM580, a retinoid derivative and RAR-α agonist, is highly potent in interrupting the life cycle of diverse viruses including Middle East respiratory...

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus

Zhang, Cun Li, Shuofeng Yuan, Wenjun Song, Jie Zhou & Bo-Jian ZhengSchool of Biological Sciences, Faculty of Science, The University of Hong Kong, Hong Kong SAR, ChinaKailash Singh & Billy K. C. Chow ... • Google ScholarSearch for Kailash Singh in:Nature Research journals • PubMed • Google ScholarSearch for Cun Li in:Nature Research journals • PubMed • Google ScholarSearch for Shuofeng Yuan in:Nature

Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines

Background Despite the development of various systems to generate live recombinant Salmonella Typhimurium vaccine strains, little work has been performed to systematically evaluate and compare their relative immunogenicity. Such information would provide invaluable guidance for the future rational design of live recombinant Salmonella oral vaccines. Result To compare vaccine...