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Search: authors:"Siddhartha P Kar"

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Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Background:Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriched for target genes of transcription factors (TFs) critical to somatic tumorigenesis.Methods:All 615 TF-target sets from the...