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8 papers found.
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Neuroreceptor kinetics in rats repeatedly exposed to quinpirole as a model for OCD

. Methodology: Stijn Servaes, Dorien Glorie, Steven Staelens. Project administration: Sigrid Stroobants, Steven Staelens. Resources: Sigrid Stroobants. Supervision: Sigrid Stroobants, Steven Staelens

MR-based spatial normalization improves [18F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington’s disease

, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens. Supervision: Jeroen Verhaeghe, Annemie Van der Linden, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav

A simulation study on the impact of the blood flow-dependent component in [18F]AV45 SUVR in Alzheimer’s disease

Staelens. Data curation: Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Sebastiaan Engelborghs, Sigrid Stroobants, Steven Staelens. Formal analysis: Julie Ottoy. Funding acquisition: Sebastiaan ... Engelborghs, Sigrid Stroobants, Steven Staelens. Investigation: Julie Ottoy, Jeroen Verhaeghe, Sigrid Stroobants, Steven Staelens. Methodology: Julie Ottoy, Jeroen Verhaeghe. Project administration: Julie

18F-FDG-PET/CT for the detection of disease in patients with head and neck cancer treated with radiotherapy

Objective The aim of this study is to evaluate the diagnostic performance of FDG-PET/CT for the detection of residual disease after (chemo)radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic value of the FDG-PET/CT findings. Methods Patients with HNSCC who underwent FDG-PET/CT after (chemo)radiotherapy were studied...

In vivo molecular neuroimaging of glucose utilization and its association with fibrillar amyloid-β load in aged APPPS1-21 mice

Introduction Radioligand imaging is a powerful in vivo method to assess the molecular basis of Alzheimer’s Disease. We therefore aimed to visualize the pathological deposition of fibrillar amyloid-β and neuronal dysfunction in aged double transgenic mice. Methods Using non-invasive positron emission tomography (PET) we assessed brain glucose utilization with [18F]FDG and...

Characterization of [99mTc]Duramycin as a SPECT Imaging Agent for Early Assessment of Tumor Apoptosis

Purpose We investigated the usefulness of [99mTc]duramycin for monitoring early response to cancer therapy in mice, with an eye towards clinical translation. Procedures [99mTc]Duramycin was injected in healthy CD1−/− mice to estimate human [99mTc]duramycin radiation dose. [99mTc]Duramycin single-photon emission computed tomography (SPECT) imaging of apoptosis was evaluated in a...

FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0

The purpose of these guidelines is to assist physicians in recommending, performing, interpreting and reporting the results of FDG PET/CT for oncological imaging of adult patients. PET is a quantitative imaging technique and therefore requires a common quality control (QC)/quality assurance (QA) procedure to maintain the accuracy and precision of quantitation. Repeatability and...