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16 papers found.
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Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism

Background The pathogenesis of cardiovascular (CV) mortality, whose rate is increased in type 2 diabetes, is poorly understood. While high serum adiponectin is associated with increased CV mortality in the general population, no data are available in type 2 diabetes. We here investigated whether this counterintuitive association was observable also in diabetic patients and...

Kidney dysfunction and related cardiovascular risk factors among patients with type 2 diabetes

Background Kidney dysfunction is a strong predictor of end-stage renal disease and cardiovascular (CV) events. The main goal was to study the clinical correlates of diabetic kidney disease in a large cohort of patients with type 2 diabetes mellitus (T2DM) attending 236 Diabetes Clinics in Italy.

Poor Glycemic Control Is an Independent Risk Factor for Low HDL Cholesterol in Patients With Type 2 Diabetes

ALESSANDRA GATTI MARIANNA MARANGHI SIMONETTA BACCI CLAUDIO CARALLO AGOSTINO GNASSO C a r d i o v a s c u l a r a n d OBJECTIVE - To determine whether the association observed between poor glycemic

Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes

Background High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes...

The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European Populations: Evidence From an Updated Meta-Analysis in 42,042 Subjects

Jarred B. McAteer Sabrina Prudente Simonetta Bacci Helen N. Lyon Joel N. Hirschhorn Vincenzo Trischitta Jose C. Florez for the ENPP Consortium OBJECTIVE-Functional studies suggest that the

Heart Rate Response During Positive Exercise Stress Test Predicts Coronary Artery Disease and Its Severity in High- Risk Type 2 Diabetic Patients With Silent Ischemia

reducing time and cost of diagnosis. SIMONETTA BACCI, MD1 TOMMASO IANGIALONGA, MD1 MASSIMO VILLELLA, MD1 ANNA RAUSEO, MD1 RAFFAELE FANELLI, MD1 VINCENZO TRISCHITTA, MD1,2 From the 1Department of ... . Address correspondence to Dr. Simonetta Bacci, Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy. E-mail: . 2003 by

Tag Polymorphisms at the A20 (TNFAIP3) Locus Are Associated With Lower Gene Expression and Increased Risk of Coronary Artery Disease in Type 2 Diabetes

Watip Boonyasrisawat Delphine Eberle Simonetta Bacci Yuan-Yuan Zhang David Nolan Ernest V. Gervino Michael T. Johnstone Vincenzo Trischitta Steven E. Shoelson Alessandro Doria alessandro.doria

The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients


The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy

Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2 diabetes. TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance. We here report that the prevalent...

The ENPP1 Q121 Variant Predicts Major Cardiovascular Events in High-Risk Individuals: Evidence for Interaction With Obesity in Diabetic Patients

Simonetta Bacci Stefano Rizza Sabrina Prudente Belinda Spoto Christine Powers Antonio Facciorusso Antonio Pacilli Davide Lauro Alessandra Testa Yuan-Yuan Zhang Giuseppe Di Stolfo Francesca Mallamaci

Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes

Adiponectin, an adipokine facilitating insulin action, has antiatherogenic effects. This study investigated whether common polymorphisms in the adiponectin receptor 1 (ADIPOR1) gene mediating these effects influence the risk of coronary artery disease (CAD) in type 2 diabetes. Linkage disequilibrium analysis of 28 single nucleotide polymorphisms (SNPs) spanning the entire ADIPOR1...

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control subjects (n = 638), type 2 diabetic patients without CAD (n = 535), and type 2 diabetic patients with...

A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians

Xiaowei Ma Simonetta Bacci Wojciech Mlynarski Lucia Gottardo Teresa Soccio Claudia Menzaghi Elisabetta Iori Robert A. Lager Adhir R. Shroff Ernest V. Gervino Richard W. Nesto Michael T. Johnstone

A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians

CD36 is a class B scavenger receptor recognizing a variety of ligands including long-chain fatty acids and modified LDL. We investigated whether genetic variability at this locus is a determinant of free fatty acid (FFA) plasma levels and risk of coronary artery disease (CAD) in Caucasians. Typing of 21 polymorphic markers, evenly spanning the CD36 gene, revealed two linkage...

The role of PC‐1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression

Background. The DD genotype of the ACE gene predisposes to faster diabetic nephropathy (DN) progression but its role in DN development is more controversial. We reported previously, in type 1 diabetic patients, an association between faster DN progression and the PC‐1 gene Q121 variant, which associates with insulin resistance in non‐diabetic subjects. We investigated here...