Advanced search    

Search: authors:"So-Yeon Park"

33 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Modeling scattered radiation from multi-leaf collimators (MLCs) to improve calculation accuracy of in-air output ratio

This study aims to model an extra-focal source for the scattered radiation from multi-leaf collimators (MLCs), namely an MLC scatter source, and to correct in-air output ratio (Sc) calculated using the conventional dual source model (DSM) to achieve better accuracy of point dose calculation. To develop the MLC scatter source, a 6 MV photon beam from a Varian Clinac® iX linear...

Assessment of the modulation degrees of intensity-modulated radiation therapy plans

To evaluate the modulation indices (MIs) for predicting the plan delivery accuracies of intensity-modulated radiation therapy (IMRT) plans. A total of 100 dynamic IMRT plans that used TrueBeam STx and 102 dynamic IMRT plans that used Trilogy were selected. For each plan, various MIs were calculated, which included the modulation complexity score (MCS), plan-averaged beam area (PA...

Comparison of the IPSA and HIPO algorithms for interstitial tongue high-dose-rate brachytherapy

Choi, So-Yeon Park, Jong Min Park, Hong-Gyun Wu. Formal analysis: Chang Heon Choi, So-Yeon Park, Jong Min Park, Hong-Gyun Wu. Funding acquisition: Chang Heon Choi, Jung-in Kim. Investigation: Hong-Gyun ... Wu, Jung-in Kim. Methodology: Jong Min Park, Jung-in Kim. Resources: Hong-Gyun Wu, Jin-Ho Kim. Software: So-Yeon Park. 10 / 12 Supervision: Hong-Gyun Wu, Jin-Ho Kim, Jung-in Kim. Validation: So

Optimal collimator rotation based on the outline of multiple brain targets in VMAT

The aim of this study was to investigate the dosimetric quality in volumetric modulated arc therapy (VMAT) plans with optimal collimator angles that can represent the outline of multiple brain targets. Twenty patients with multiple target volumes in the brain cases were selected retrospectively. To better represent the outline of the multiple brain targets, four conformal arc...

Integrative analyses of genes and microRNA expressions in human trisomy 21 placentas

The most frequent chromosomal aneuploidy is trisomy 21 (T21) that is caused by an extra copy of chromosome 21. The imbalance of whole genome including genes and microRNAs contributes to the various phenotypes of T21. However, the integrative association between genes and microRNAs in the T21 placenta has yet to be determined. We analyzed the expressions of genes and microRNAs in...

A comparison of Ki-67 counting methods in luminal Breast Cancer: The Average Method vs. the Hot Spot Method

In spite of the usefulness of the Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability in its measurement and the absence of a standard method of interpretation. This study was designed to compare the two methods of assessing Ki-67 LI: the average method vs. the hot spot method and thus to...

Dosimetric characteristics of a reusable 3D radiochromic dosimetry material

government (MSIP) Conceptualization: Jong Min Park, Jung-in Kim. Data curation: So-Yeon Park, Minsoo Chun, Ji Hye Han, Jin Dong Cho. Formal analysis: Jong Min Park, Minsoo Chun, Ji Hye Han, Jin Dong Cho ... . Funding acquisition: Jong Min Park, Jung-in Kim. Investigation: So-Yeon Park, Chang Heon Choi, Minsoo Chun, Ji Hye Han, Jin Dong Cho. Methodology: Jong Min Park, Minsoo Chun, Jung-in Kim. Project

Dosimetric effects of sectional adjustments of collimator angles on volumetric modulated arc therapy for irregularly-shaped targets

Purpose To calculate an optimal collimator angle at each of sectional arcs in a full-arc volumetric modulated arc therapy (VMAT) plan and evaluate dosimetric quality of these VMAT plans comparing full-arc VMAT plans with a fixed collimator angle. Methods Seventeen patients who had irregularly-shaped target in abdominal, head and neck, and chest cases were selected retrospectively...

The effect of extremely narrow MLC leaf width on the plan quality of VMAT for prostate cancer

Background To investigate the effect of multi-leaf collimators (MLCs) with leaf width of 1.25 mm on the plan quality of volumetric modulated arc therapy (VMAT) for prostate cancer. Methods A total of 20 patients with prostate cancer were retrospectively selected. Using a high definition MLC (HD MLC), primary and boost VMAT plans with two full arcs were generated for each patient...

A Patient-Specific Polylactic Acid Bolus Made by a 3D Printer for Breast Cancer Radiation Therapy

Purpose The aim of this study was to assess the feasibility and advantages of a patient-specific breast bolus made using a 3D printer technique. Methods We used the anthropomorphic female phantom with breast attachments, which volumes are 200, 300, 400, 500 and 650 cc. We simulated the treatment for a right breast patient using parallel opposed tangential fields. Treatment plans...

The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis

Lichens are symbiotic organisms that produce various secondary metabolites. Here, different lichen extracts were examined to identify secondary metabolites with anti-migratory activity against human lung cancer cells. Everniastrum vexans had the most potent inhibitory activity, and atranorin was identified as an active subcomponent of this extract. Atranorin suppressed β-catenin...

The effect of extremely narrow MLC leaf width on the plan quality of VMAT for prostate cancer

To investigate the effect of multi-leaf collimators (MLCs) with leaf width of 1.25 mm on the plan quality of volumetric modulated arc therapy (VMAT) for prostate cancer. A total of 20 patients with prostate cancer were retrospectively selected. Using a high definition MLC (HD MLC), primary and boost VMAT plans with two full arcs were generated for each patient (original plan...

Ultrasound-guided cable-free 13-gauge vacuum-assisted biopsy of non-mass breast lesions

Purpose To compare the outcomes of ultrasound-guided core biopsy for non-mass breast lesions by the novel 13-gauge cable-free vacuum-assisted biopsy (VAB) and by the conventional 14-gauge semi-automated core needle biopsy (CCNB). Materials and methods Our institutional review board approved this prospective study, and all patients provided written informed consent. Among 1840...

Texture analysis on the edge-enhanced fluence of VMAT

Background Textural features of edge-enhanced fluence were analysed to quantify modulation degree of volumetric modulated arc therapy (VMAT) plans. Methods Twenty prostate and twenty head and neck VMAT plans were retrospectively selected. Fluences of VMAT plans were generated by integration of monitor units shaped by multi-leaf collimators (MLCs) at each control point. When...

Texture analysis on the edge-enhanced fluence of VMAT

Textural features of edge-enhanced fluence were analysed to quantify modulation degree of volumetric modulated arc therapy (VMAT) plans. Twenty prostate and twenty head and neck VMAT plans were retrospectively selected. Fluences of VMAT plans were generated by integration of monitor units shaped by multi-leaf collimators (MLCs) at each control point. When generating fluences, the...

Prognostic Value of Tumor-Associated Macrophages According to Histologic Locations and Hormone Receptor Status in Breast Cancer

Tumor-associated macrophages (TAMs) are involved in tumor progression by promoting epithelial-mesenchymal transition (EMT), tumor cell invasion, migration and angiogenesis. However, in breast cancer, the clinical relevance of the TAM infiltration according to distinct histologic locations (intratumoral vs. stromal) and hormone receptor status is unclear. We investigated the...

TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

Transforming growth factor-β (TGF-β) signaling plays a key role in progression and metastasis of HCC. This study was undertaken to gain the proof of concept of a small-molecule inhibitor of TGF-β type I receptor kinase, EW-7197 as a potent anti-cancer therapy for HCC. We identified tissue inhibitors of metalloproteinases-1 (TIMP-1) as one of the secreted proteins of hepatic...

The sensitivity of gamma-index method to the positioning errors of high-definition MLC in patient-specific VMAT QA for SBRT

Background To investigate the sensitivity of various gamma criteria used in the gamma-index method for patient-specific volumetric modulated arc therapy (VMAT) quality assurance (QA) for stereotactic body radiation therapy (SBRT) using a flattening filter free (FFF) photon beam. Methods Three types of intentional misalignments were introduced to original high-definition multi...

Dosimetric comparison of 4 MeV and 6 MeV electron beams for total skin irradiation

Background In this study, dosimetric aspects of TSEI consisting of a 4 MeV beam with no spoiler were investigated in comparison to a nominal 6 MeV beam with spoiler, and the potential for clinical applications was evaluated. Methods The TSEI technique is based on the Stanford technique, which utilizes a beam configuration of six-dual fields. MOSFETs were used to measure the...