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25 papers found.
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Impact of a selective cyclooxygenase-2 inhibitor, celecoxib, on cortical excitability and electrophysiological properties of the brain in healthy volunteers: A randomized, double-blind, placebo-controlled study

Contributions Conceptualization: Ki-Young Jung, Kon Chu, Sang Kun Lee, Kyung-Il Park. Formal analysis: Jung-Ah Lim, Ki-Young Jung, Boram Park, Tae-Joon Kim, Jin-Sun Jun, Keun Tae Kim, Tae-Won Yang, Soon-Tae Lee

HLA-A*11:01 is associated with levetiracetam-induced psychiatric adverse events

-Joon Kim. Supervision: Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee. Validation: Soon-Tae Lee, Keun-Hwa Jung. Visualization: Tae-Joon Kim. Writing ? original draft: Tae-Won Yang, Jangsup Moon

High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis

). S.T.L was supported by a research grant by Samjin Pharm (Seoul National University Hospital #0620170830). Author information Author notes Yoonhyuk Jang and Soon-Tae Lee contributed equally to this work ... . AffiliationsDepartment of Neurology, Seoul National University Hospital, Seoul, South KoreaYoonhyuk Jang, Soon-Tae Lee, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kon Chu & Sang Kun LeeDepartment of Neurology

Depletion of nerve growth factor in chemotherapy-induced peripheral neuropathy associated with hematologic malignancies

express our thanks to the patients who voluntarily participated in this study. Author Contributions Conceptualization: Soon-Tae Lee, Inho Kim. Formal analysis: Jeonghwan Youk, Dong-Yeop Shin, Youngil Koh ... , Soon-Tae Lee. Funding acquisition: Soon-Tae Lee, Inho Kim. Methodology: Young-Sook Kim, Jung-Ah Lim. Project administration: Young-Sook Kim, Inho Kim. Resources: Young-Sook Kim, Jung-Ah Lim, Inho Kim

Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model

: Jung-Ah Lim, Jangsup Moon, Kyung-Il Park, Soon-Tae Lee, Keun-Hwa Jung, Ki-Young Jung, Manho Kim. 9 / 11 Investigation: Tae-Joon Kim, Jin-Sun Jun, Byeongsu Park, Jung-Ick Byun, Jun-Sang Sunwoo

Cystatin C, a potential marker for cerebral microvascular compliance, is associated with white-matter hyperintensities progression

. Investigation: Woo-Jin Lee, Young Jin Ryu, Soon-Tae Lee. Methodology: Young Jin Ryu, Soon-Tae Lee, Kon Chu. Project administration: Manho Kim. Resources: Jeong-Min Kim. Software: Jeong-Min Kim. Validation

Association of blood pressure variability with orthostatic intolerance symptoms

The short-term blood pressure variability (BPV) reflects autonomic regulatory mechanisms. However, the influence of BPV in orthostatic intolerance (OI) is unknown. Herein, we assessed BPV profiles in patients with OI and determined their association with orthostatic symptoms. In this cross-sectional study, we prospectively enrolled 126 patients presenting with OI at the Seoul...

Gamma oscillation in functional brain networks is involved in the spontaneous remission of depressive behavior induced by chronic restraint stress in mice

Background Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients with depression experience spontaneous remission without any treatment. However, the relationship between electroencephalographic (EEG) functional connectivity...

MR Imaging Analysis of Non-Measurable Enhancing Lesions Newly Appearing after Concomitant Chemoradiotherapy in Glioblastoma Patients for Prognosis Prediction

Purpose To analyze the enhancement patterns and apparent diffusion coefficient (ADC) values of non-measurable surgical cavity wall enhancement pattern, newly appearing after completion of standard concurrent chemoradiotherapy (CCRT) with temozolomide in glioblastoma patients for the prognosis prediction. Materials and Methods From January 2010 to April 2014, among 190 patients...

Rhythmical Photic Stimulation at Alpha Frequencies Produces Antidepressant-Like Effects in a Mouse Model of Depression

Current therapies for depression consist primarily of pharmacological agents, including antidepressants, and/or psychiatric counseling, such as psychotherapy. However, light therapy has recently begun to be considered as an effective tool for the treatment of the neuropsychiatric behaviors and symptoms of a variety of brain disorders or diseases, including depression. One...

Orthostatic intolerance symptoms are associated with depression and diminished quality of life in patients with postural tachycardia syndrome

Background Patients with postural tachycardia syndrome often appear depressive and report diminished quality of life (QOL). In the current study, we first evaluated if the maximal heart rate (HR) increment after standing is associated with the clinical symptoms in patients with excessive orthostatic tachycardia (OT). Next, we investigated the correlations among the symptoms of...

Extracts of Adipose Derived Stem Cells Slows Progression in the R6/2 Model of Huntington's Disease

Stem cell therapy is a promising treatment for incurable disorders including Huntington's disease (HD). Adipose-derived stem cell (ASC) is an easily available source of stem cells. Since ASCs can be differentiated into nervous stem cells, it has clinically feasible potential for neurodegenerative disease. In addition, ASCs secrete various anti-apoptotic growth factors, which...

The long-term efficacy and safety of levetiracetam in a tertiary epilepsy centre

AimTo evaluate the long-term efficacy and safety of levetiracetam based on a large population of patients in a tertiary epilepsy centre.MethodsAll patients who received levetiracetam at the Seoul National University Hospital between January 2007 and March 2009 were evaluated. Patients who underwent brain surgery for seizure control or who had associated progressive disease were...

Echocardiographic Evidence of Innate Aortopathy in the Human Intracranial Aneurysm

Background Intracranial aneurysm (IA) is significantly more prevalent in patients with coarctation of the aorta or bicuspid aortic valve than in the general population, suggesting a common pathophysiology connecting IA and aortopathy. Here, we analyzed echocardiographic aortic root dimension (ARD) in patients with IA to confirm this possibility. Methods From January 2008 to...

Inhibition of Let7c MicroRNA Is Neuroprotective in a Rat Intracerebral Hemorrhage Model

Intracerebral hemorrhage (ICH) is a devastating neurological disease with a grave prognosis. We evaluated microRNA (miRNA) expression after ICH and evaluated Let7c as a therapeutic target. We harvested hemorrhagic brain 24 hours after collagenase induced ICH in the rat. Microarray analysis was performed to compare the miRNAs expression pattern between hemorrhagic hemisphere and...

Dynamic Temporal Change of Cerebral Microbleeds: Long-Term Follow-Up MRI Study

Background Cerebral microbleeds (MBs) are understood as an important radiologic marker of intracerebral hemorrhage. We sought to investigate the temporal changes of MBs and clinical factors associated with the changes using long-term follow-up MRI. Methods/Principal Findings From October 2002 to July 2006, we prospectively enrolled patients with stroke or transient ischemic...

Unique Behavioral Characteristics and microRNA Signatures in a Drug Resistant Epilepsy Model

Background Pharmacoresistance is a major issue in the treatment of epilepsy. However, the mechanism underlying pharmacoresistance to antiepileptic drugs (AEDs) is still unclear, and few animal models have been established for studying drug resistant epilepsy (DRE). In our study, spontaneous recurrent seizures (SRSs) were investigated by video-EEG monitoring during the entire...

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an expansion of cytosine-adenine-guanine repeats in the huntingtin gene. The aggregation of mutant huntingtin (mtHTT) and striatal cell loss are representative features to cause uncontrolled movement and cognitive defect in HD. However, underlying mechanism of mtHTT aggregation and cell toxicity...