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Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum

Angela Huttner 0 Stephan Harbarth 0 Jean Carlet Sara Cosgrove Herman Goossens Alison Holmes Vincent Jarlier Andreas Voss Didier Pittet 0 for the World Healthcare-Associated Infections Forum ... Kulakkattil Ghafur (India), Achilles Gikas (Greece), Marek Gniadkowski (Poland), Herman Goossens (Belgium), Thomas Gottlieb (Australia), M. Lindsay Grayson (Australia), Manuel Guzman (Venezuela), Stephan

Prevention of hospital-acquired pneumonia in non-ventilated adult patients: a narrative review

Background Pneumonia is one of the leading hospital-acquired infections worldwide and has an important impact. Although preventive measures for ventilator-associated pneumonia (VAP) are well known, less is known about appropriate measures for prevention of hospital-acquired pneumonia (HAP). Aim The purpose of this narrative review is to provide an overview of the current...

Hydrogen peroxide room disinfection – ready for prime time?

Non-manual techniques for terminal disinfection of hospital rooms have gained increasing interest in recent years as means to reduce transmission of multidrug-resistant organisms (MDROs). A prospective crossover study by Blazejewski and colleagues in five ICUs of a French academic hospital with a high prevalence of MDRO carriers showed that two different hydrogen peroxide (H2O2...

Comparative Genomics of Community-Associated Methicillin-Resistant Staphylococcus aureus Shows the Emergence of Clone ST8-USA300 in Geneva, Switzerland

Background. Previous investigations of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates have revealed a wide diversity of genetic backgrounds, with only sporadic occurrence of ST8-USA300, in Geneva, Switzerland. We conducted a molecular epidemiologic analysis to identify the origin of a sudden increase of ST8 PVL–positive isolates in Geneva...

Low frequency of asymptomatic carriage of toxigenic Clostridium difficile in an acute care geriatric hospital: prospective cohort study in Switzerland

Background The role of asymptomatic carriers of toxigenic Clostridium difficile (TCD) in nosocomial cross-transmission remains debatable. Moreover, its relevance in the elderly has been sparsely studied. Objectives To assess asymptomatic TCD carriage in an acute care geriatric population. Methods We performed a prospective cohort study at the 296-bed geriatric hospital of the...

Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net

Purpose In this era of rising antimicrobial resistance, slowly refilling antibiotic development pipelines, and an aging population, we need to ensure that randomized clinical trials (RCTs) determine the added benefit of new antibiotic agents effectively and in a valid way, especially for severely ill patients. Unfortunately, universally accepted endpoints for the evaluation of...

The effect of improved hand hygiene on nosocomial MRSA control

The purpose of this review is to examine studies that have assessed the association between hand hygiene enhancement and methicillin-resistant Staphylococcus aureus (MRSA) rates and to explore controversies surrounding this association. Many studies have been published confirming the link between improved hand hygiene compliance and reduction in MRSA acquisition and infections...

De-escalation as a potential way of reducing antibiotic use and antimicrobial resistance in ICU

Jean-Francois Timsit Stephan Harbarth Jean Carlet - First, on an individual basis, antibiotic therapy clearly The study is important because it is the first eagerly awaited increases the risk of

Multisite Infection with Mycobacterium abscessus after Replacement of Breast Implants and Gluteal Lipofilling

Introduction. Medical tourism for aesthetic surgery is popular. Nontuberculous mycobacteria (NTM) occasionally cause surgical-site infections. As NTM grow in biofilms, implantations of foreign bodies are at risk. Due to late manifestation, infections occur when patients are back home, where they must be managed properly. Case Report. A 39-year-old healthy female was referred for...

Adjunctive Corticotherapy for Community Acquired Pneumonia: A Systematic Review and Meta-Analysis

Background Community-acquired pneumonia (CAP) induces lung and systemic inflammation, leading to high morbidity and mortality. We systematically reviewed the risks and benefits of adjunctive corticotherapy in the management of patients with CAP. Methods We systematically searched Pubmed, Embase and the Cochrane Library for randomized controlled trials comparing adjunctive...

Predictors and Implications of Early Clinical Stability in Patients Hospitalized for Moderately Severe Community-Acquired Pneumonia

Background Assessment of early response to treatment is crucial for the management of community-acquired pneumonia (CAP). Objective To describe the predictors and the outcomes of early clinical stability Methods We did a secondary analysis of a multicentre randomized controlled trial on CAP treatment in which 580 patients hospitalized for moderately severe CAP were included. The...

Antimicrobial resistance: one world, one fight!

(USA), Marek Gniadkowski (Poland), Herman Goossens (Belgium), Thomas Gottlieb (Australia), Lindsay Grayson (Australia),Hajo Grundmann (Netherlands), Yoshiaki Gu (Japan), Deniz Gur (Turkey), Stephan ... Harbarth (Switzerland), Loreen Herwaldt (USA), Alison Holmes (UK), Susan Huang (USA), Benedikt Huttner (Switzerland), Nordiah Jalil (Malaysia), Vincent Jarlier (France), John Jernigan (USA) ; James R

Year in review 2011: Critical Care - infection

There is an ever-growing importance for critical assessment of benefits and harms of various strategies with regards to antibiotic stewardship, infection control, molecular detection of pathogens and adequate treatment of multidrug-resistant organisms in ICUs. Ongoing financial constraints globally, changing demographics with an increasing and aging population and the slow...

Clostridium: Transmission difficile?

Stephan Harbarth and Matthew Samore discuss the implications, and the limitations, of new research that might indicate that most Clostridium difficile cases are imported into hospitals.

Variable performance of models for predicting methicillin-resistant Staphylococcus aureus carriage in European surgical wards

Harbarth 1 Andrea Patroni 6 Annie Chalfine 5 George L Daikos 4 Silvia Garilli 2 José Antonio Martínez 3 Ben S Cooper 7 8 in collaboration with the MOSAR- Study Team 0 Departments of Infectious Diseases and

Year in review 2010: Critical Care - infection

Infections remain among the most important concerns in critically ill patients. Early and reliable diagnosis of infection still poses difficulties in this setting but also represents a crucial step toward appropriate antimicrobial therapy. Increasing antimicrobial resistance challenges established approaches to the optimal management of infections in the intensive care unit...

Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection - a new frontier?

Arash Afshari 0 Jacques Schrenzel Margareta Ieven Stephan Harbarth 0 0 Infection Control Program, Geneva University Hospitals and Medical School , 4, rue Gabrielle-Perret-Gentil, CH-1211 Geneva 14

Year in review 2009: Critical Care - infection

Stephan Harbarth 0 Thomas Haustein 0 0 Infection Control Program, Geneva University Hospitals and Medical School , 4 rue G-P-G, CH-1211 Geneva 14 , Switzerland In 2009 Critical Care provided