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Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent?

Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent? Sukhwinder Singh Sohal Discipline of Laboratory Medicine, School of Health Sciences, Faculty of Health

Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease

Sukhwinder Singh Sohal 0 Stephen Myers 0 0 Faculty of Health, School of Health Sciences, University of Tasmania , Newnham Campus, Launceston, TAS 7250 , Australia Background: Zinc is a metal ion that is

Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease

Sukhwinder Singh Sohal 0 Stephen Myers 0 0 Faculty of Health, School of Health Sciences, University of Tasmania , Newnham Campus, Launceston, TAS 7250 , Australia Background: Zinc is a metal ion that is

Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease

Sukhwinder Singh Sohal 0 Stephen Myers 0 0 Faculty of Health, School of Health Sciences, University of Tasmania , Newnham Campus, Launceston, TAS 7250 , Australia Background: Zinc is a metal ion that is

Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease

Sukhwinder Singh Sohal 0 Stephen Myers 0 0 Faculty of Health, School of Health Sciences, University of Tasmania , Newnham Campus, Launceston, TAS 7250 , Australia Background: Zinc is a metal ion that is

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven inflammatory diseases. However, the effect of MCC950 on colonic inflammation has not yet been reported. In the present study we investigated the effect of MCC950 in a spontaneous chronic colitis mouse model...

β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction

COPD is characterised by poorly reversible airflow obstruction usually due to cigarette smoking. The transcription factor clusters of β-catenin/Snail1/Twist has been implicated in the process of epithelial mesenchymal transition (EMT), an intermediate between smoking and airway fibrosis, and indeed lung cancer. We have investigated expression of these transcription factors and...

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)

Tillie-Louise Hackett in:Nature Research journals • PubMed • Google Scholar Search for Eugene H. Walters in:Nature Research journals • PubMed • Google Scholar Search for Sukhwinder Singh Sohal in:Nature ... preparation of the manuscript. All authors reviewed the manuscript. Competing Interests The authors declare that they have no competing interests. Corresponding author Correspondence to Sukhwinder Singh

ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)

Sukhwinder Singh Sohal 1 Elizabeth T. Snow 1 0 Department of Primary Industries, Parks Water and Environment, Animal Health Laboratory , Launceston, Tasmania , Australia , 2 Save the Tasmanian Devil Program

Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses

Inflammatory bowel diseases, such as ulcerative colitis, cause significant morbidity and decreased quality of life. The currently available treatments are not effective in all patients, can be expensive and have potential to cause severe side effects. This prompts the need for new treatment modalities. Enoxaparin, a widely used antithrombotic agent, is reported to possess anti...

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease Shakti Dhar Shukla,1,* Sukhwinder Singh Sohal,1,* Malik Quasir ... lnodow rsnope PowerdbyTCPDF(ww.tcpdf.org) O r I g I n a l r e s e a r C h sukhwinder singh sohal 1,* David reid 2 hans Konrad Muller 1 eugene haydn Walters 1 Background: We recently published that platelet

Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction

Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction Malik Quasir Mahmood,1,* Sukhwinder Singh Sohal,1,2,* Shakti Dhar Shukla,1 Chris Ward,3 ... l.y rom on f e d s de lu loa ona PowerdbyTCPDF(ww.tcpdf.org) O r I g I n a l r e s e a r C h sukhwinder singh sohal 1,2,* shakti Dhar shukla 1 ashutosh hardikar 4 hans Konrad Muller 1 Darr yl a Knight 5

Non-Anticoagulant Fractions of Enoxaparin Suppress Inflammatory Cytokine Release from Peripheral Blood Mononuclear Cells of Allergic Asthmatic Individuals

Background Enoxaparin, a low-molecular-weight heparin, is known to possess anti-inflammatory properties. However, its clinical exploitation as an anti-inflammatory agent is hampered by its anticoagulant effect and the associated risk of bleeding. Objective The aim of the current study was to examine the ability of non-anticoagulant fractions of enoxaparin to inhibit the release...

Opposing Effects of Low Molecular Weight Heparins on the Release of Inflammatory Cytokines from Peripheral Blood Mononuclear Cells of Asthmatics

Background T-cell-mediated inflammatory cytokines, such as interleukin (IL)-4, IL-5, IL-13 and tumor necrosis factor-alpha (TNF-α), play an important role in the initiation and progression of inflammatory airways diseases. Low-molecular-weight heparins (LMWHs), widely used anticoagulants, possess anti-inflammatory properties making them potential treatment options for...

A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial–mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study

Singh Sohal,1,* Amir Soltani,1,* David Reid,1,2 Chris Ward,1,3 Karen E Wills,1,4 H. Konrad Muller,1 Eugene Haydn Walters1 1National Health and Medical Research Council Centre of Research Excellence for ... singh sohal 1,* amir soltani 1,* David reid 1,2 lung cancer in COPD. Background Smoking-related chronic obstructive pulmonary disease (COPD) is the fourth most common cause of chronic disability and

Changes in Airway Histone Deacetylase2 in Smokers and COPD with Inhaled Corticosteroids: A Randomized Controlled Trial

The expression of HDAC2 is reported as reduced in chronic obstructive pulmonary disease (COPD). We assessed HDAC2 expression within the airways of smokers and subjects with COPD and effects of inhaled corticosteroids (ICS), using immuno-histology to contrast with previous molecular methodology. Endobronchial biopsies (ebb) from current smokers with COPD (COPD-CS; n = 15), ex...

Vessel-Associated Transforming Growth Factor-Beta1 (TGF-β1) Is Increased in the Bronchial Reticular Basement Membrane in COPD and Normal Smokers

Background Transforming growth factor-beta1 (TGF-β1) is a multipotential cytokine with angiogenic activity. There are only limited data about its role in airway remodeling in COPD. We have previously shown that the reticular basement membrane (Rbm) is hypervascular in the airways of current smokers either with or without chronic obstructive pulmonary disease (COPD). This study...