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Monitoring polycyclic aromatic hydrocarbon concentrations and distributions in rice paddy soils from Gyeonggi-do, Ulsan, and Pohang

first authors Hoon Choi, Tae-Oh Kim and Sung-Eun Lee have equally contributed to this paper as corresponding authors Electronic supplementary material The online version of this article ( https://doi.org

B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15

Kyeongsoon Kim Sung-Eun Lee Published: xx xx xxxx Fibroblast growth factor 21 (FGF21) is a hormone that is vital for the regulation of metabolic homeostasis. In the present study, we report that Kruppel-like

Repositioning of the antipsychotic drug TFP for sepsis treatment

Sepsis is a disease responsible for the death of almost all critical patients. Once infected by virus or bacteria, patients can die due to systemic inflammation within a short period of time. Cytokine storm plays an essential role in causing organ dysfunction and septic shock. Thus, inhibition of cytokine secretion is considered very important in sepsis therapy. In this study, we...

Central and cerebral haemodynamic changes after antihypertensive therapy in ischaemic stroke patients: A double-blind randomised trial

Central and cerebral haemodynamic parameters can vary under similar brachial blood pressure (BP). We aimed to investigate the effects of antihypertensive agents on central and cerebral haemodynamic parameters in hypertensive patients with ischaemic stroke. The Fimasartan, Atenolol, and Valsartan On haemodynamic paRameters (FAVOR) study was conducted in a prospective, double...

Comparison of theoretical and experimental values for plant uptake of pesticide from soil

Pesticides that persist in soils may be taken up by the roots of plants. One way to assess plant uptake is to theoretically predict the extent of plant uptake using a mathematical model. In this study, a model was developed to predict plant uptake of pesticide residues in soils using various parameters, such as pesticide mobility within soil, plant transpiration stream, root–soil...

Plant Uptake and Distribution of Endosulfan and Its Sulfate Metabolite Persisted in Soil

The distributions of endosulfan (ED) residues (α-, β-isomers, and sulfate-metabolite) in cucumbers grown in soils treated with ED at concentrations of 20 and 40 mg kg-1 were assessed using indoor and outdoor experiments. In all treatments, degradation rates of the α-isomer in soils were higher than that of the β-isomer. In the indoor tests, uptake amounts of total ED by cucumbers...

Oral proteasome inhibitor with strong preclinical efficacy in myeloma models

Background The proteasome is a validated anti-cancer target and various small-molecule inhibitors are currently in clinical development or on the market. However, adverse events and resistance associated with those proteasome inhibitors indicate the need for a new generation of drugs. Therefore, we focused on developing an oral proteasome inhibitor with improved efficacy and...

Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives

Pesticidal activities of 4-[5-(2-cyclopropylaminopyrimidin-4-yl)-4-(4-chloro-2-fluoro-phenyl)thiazol-2-yl]-1-methylpiperidine, designated as Comp I, have been determined against a mosquito larva, Culex pipiens pallens, and a phytopathogenic fungus, Phytophthora capsici. Comp I was used as the leading compound in this study. The compounds were synthesized by reacting them with two...

Model-based adaptive phase I trial design of post-transplant decitabine maintenance in myelodysplastic syndrome

Background This report focuses on the adaptive phase I trial design aimed to find the clinically applicable dose for decitabine maintenance treatment after allogeneic hematopoietic stem cell transplantation in patients with higher-risk myelodysplastic syndrome and secondary acute myeloid leukemia. Methods The first cohort (three patients) was given the same initial daily dose of...