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Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women

Background In clinical trials, vaccines against human papillomavirus (HPV) have been highly effective against HPV16- or HPV18-associated cervical lesions. The quadrivalent HPV vaccine was licensed in 2006 and subsequently implemented in the Danish vaccination program. The study aim was to use individual information on HPV vaccination status to assess subsequent risk of cervical...

Strongly Decreased Risk of Genital Warts After Vaccination Against Human Papillomavirus: Nationwide Follow-up of Vaccinated and Unvaccinated Girls in Denmark

Background. A reduction in the incidence of genital warts (GWs) is one of the first markers of the effectiveness of vaccination against human papillomavirus (HPV) at the population level. The aim of this cohort study was to use individual information on HPV vaccination status to assess the effect on risk of GWs. Methods. Population-based registries were used to identify all girls...

Prescription Use of Paracetamol and Risk for Ovarian Cancer in Denmark

Jørgen H. Olsen 0 Susanne KKjaer ) 0 0 Center , Strandboulevarden 49, Copenhagen DK-2100 , Denmark ( It has been suggested that paracetamol reduces the risk for ovarian cancer.We examined the

Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience

Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January 2007 through February 2016 to identify observational studies reporting the...

Genital Warts and Risk of Cancer: A Danish Study of Nearly 50 000 Patients With Genital Warts

Background We conducted a large national cohort study to examine the risk of cancer among men and women with genital warts (GW).

Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study

, Heidi Sharif, Susanne K. Kjaer); and Gynecologic Clinic, The Juliane Marie Center, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark (Susanne K. Kjaer). This research was supported by the

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

Paul D.P. Pharoah Honglin Song Susanne K. Kjaer Estrid Hogdall Claus Hogdall Alice S. Whittemore Valerie McGuire Weiva Sieh Jacek Gronwald Krzysztof Medrek Anna Jakubowska Jan Lubinski Georgia Chenevix

Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women

Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were “negative to 14 HPV types” and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group).

The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Generally HPV-Naive Women Aged 16–26 Years

BackgroundHuman papillomavirus (HPV)–6/11/16/18 vaccine reduces the risk of HPV-6/11/16/18–related cervical intraepithelial neoplasia (CIN) 1–3 or adenocarcinoma in situ (AIS). Here, its impact on CIN1–3/AIS associated with nonvaccine oncogenic HPV types was evaluated MethodsWe enrolled 17,622 women aged 16–26 years. All underwent cervicovaginal sampling and Pap testing at...