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Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferation, cell motility, and vesicle transport. We hypothesized that common germline...

Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study

Background:Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer.Methods:We examined the association between postdiagnosis use of low-dose aspirin and mortality in a nationwide cohort of women with epithelial ovarian cancer between 2000 and 2012. Information on filled prescriptions of low-dose aspirin, dates and...

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Florian Heitz Michelle A T Hildebrandt Estrid H?gdall Claus K H?gdall David G Huntsman Allan Jensen Beth Y Karlan Linda E Kelemen Lambertus A Kiemeney Susanne K Kjaer Jolanta Kupryjanczyk Diether Lambrechts

Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience

Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January 2007 through February 2016 to identify observational studies reporting the...

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including...

Prescription Use of Paracetamol and Risk for Ovarian Cancer in Denmark

Jørgen H. Olsen 0 Susanne KKjaer ) 0 0 Center , Strandboulevarden 49, Copenhagen DK-2100 , Denmark ( It has been suggested that paracetamol reduces the risk for ovarian cancer.We examined the

Early Impact of Human Papillomavirus Vaccination on Cervical Neoplasia—Nationwide Follow-up of Young Danish Women

Background In clinical trials, vaccines against human papillomavirus (HPV) have been highly effective against HPV16- or HPV18-associated cervical lesions. The quadrivalent HPV vaccine was licensed in 2006 and subsequently implemented in the Danish vaccination program. The study aim was to use individual information on HPV vaccination status to assess subsequent risk of cervical...

Strongly Decreased Risk of Genital Warts After Vaccination Against Human Papillomavirus: Nationwide Follow-up of Vaccinated and Unvaccinated Girls in Denmark

Background. A reduction in the incidence of genital warts (GWs) is one of the first markers of the effectiveness of vaccination against human papillomavirus (HPV) at the population level. The aim of this cohort study was to use individual information on HPV vaccination status to assess the effect on risk of GWs. Methods. Population-based registries were used to identify all girls...

Genital Warts and Risk of Cancer: A Danish Study of Nearly 50 000 Patients With Genital Warts

Background We conducted a large national cohort study to examine the risk of cancer among men and women with genital warts (GW).

Sexual risk taking behaviour: prevalence and associated factors. A population-based study of 22 000 Danish men

Kjaer 0 1 0 Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society , DK-2100 Copenhagen , Denmark 1 Department of Obstetrics and Gynaecology, Rigshospitalet

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

Paul D.P. Pharoah Honglin Song Susanne K. Kjaer Estrid Hogdall Claus Hogdall Alice S. Whittemore Valerie McGuire Weiva Sieh Jacek Gronwald Krzysztof Medrek Anna Jakubowska Jan Lubinski Georgia Chenevix

Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”

We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes involved in stromal epithelial interactions in the Ovarian Cancer Association...

Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women

Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were “negative to 14 HPV types” and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group).

Use of Fertility Drugs and Risk of Uterine Cancer: Results From a Large Danish Population-based Cohort Study

, Heidi Sharif, Susanne K. Kjaer); and Gynecologic Clinic, The Juliane Marie Center, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark (Susanne K. Kjaer). This research was supported by the

The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Generally HPV-Naive Women Aged 16–26 Years

BackgroundHuman papillomavirus (HPV)–6/11/16/18 vaccine reduces the risk of HPV-6/11/16/18–related cervical intraepithelial neoplasia (CIN) 1–3 or adenocarcinoma in situ (AIS). Here, its impact on CIN1–3/AIS associated with nonvaccine oncogenic HPV types was evaluated MethodsWe enrolled 17,622 women aged 16–26 years. All underwent cervicovaginal sampling and Pap testing at...

YKL-40 tissue expression and plasma levels in patients with ovarian cancer

Jarle Christensen Julia S Johansen Susanne K Kjaer Jan Blaakaer Lene Ostenfeld-Mller Paul A Price Lise H Christensen Background: YKL-40 (chitinase-3-like-1) is a member of "mammalian chitinase