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Search: authors:"Swerdlow, Anthony J"

14 papers found.
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Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study

Growth hormone (GH) is prescribed for an increasing range of indications, but there has been concern that it might raise cancer risk. Published data are limited.

Risk of Premature Menopause After Treatment for Hodgkin’s Lymphoma

Modern treatment of Hodgkin’s lymphoma (HL) has transformed its prognosis but causes late effects, including premature menopause. Cohort studies of premature menopause risks after treatment have been relatively small, and knowledge about these risks is limited.

Tamoxifen Treatment for Breast Cancer and Risk of Endometrial Cancer: A Case–Control Study

Background: Tamoxifen treatment of breast cancer is associated with an increased risk of endometrial cancer, but tamoxifen-related risks of endometrial cancer are unclear in premenopausal women, in long-term users of tamoxifen, and in women for whom several years have passed since ending treatment. We conducted a case–control study in Britain to investigate these risks. Methods...

Mortality in Women with Turner Syndrome in Great Britain: A National Cohort Study

Context: Turner syndrome is characterized by complete or partial X chromosome monosomy. It is associated with substantial morbidity, but mortality risks and causes of death are not well described.

Infectious Mononucleosis in University Students in the United Kingdom: Evaluation of the Clinical Features and Consequences of the Disease

Infectious mononucleosis (IM) resulted in marked reductions in student study time, social activities, and physical exercise, and sustained hypersomnia. Females were more likely to discontinue their studies following IM and reported more-prolonged fatigue. Elevated levels of γΔ T cells persisted into the convalescent period.

Mortality in Patients with Klinefelter Syndrome in Britain: A Cohort Study

Context: Klinefelter syndrome is characterized by hypogonadism and infertility, consequent on the presence of extra X chromosome(s). There is limited information about long-term mortality in this syndrome because there have been no large cohort studies.

Cancer Incidence and Mortality in Men with Klinefelter Syndrome: A Cohort Study

Background: Men with Klinefelter syndrome have one or more extra X chromosomes and have endocrine abnormalities. Case reports have led to suggestions that men with Klinefelter syndrome have elevated risks of several cancers, but published cohort studies have been relatively small. We conducted a nationwide cohort study to examine these risks. Methods: We followed a cohort of 3518...

A Cohort Study among University Students: Identification of Risk Factors for Epstein-Barr Virus Seroconversion and Infectious Mononucleosis

Background. A vaccine against Epstein-Barr virus (EBV) infection is in clinical trials. Up-to-date information on risk factors for EBV infection and infectious mononucleosis (IM) among young adults is required to inform a vaccination strategy.

Myocardial Infarction Mortality Risk After Treatment for Hodgkin Disease: A Collaborative British Cohort Study

Myocardial infarction is a major cause of excess long-term mortality in survivors of Hodgkin disease, but limited information exists on the effects of specific chemotherapy regimens used to treat these patients on their risk of death from myocardial infarction.

Inherited variation in immune genes and pathways and glioblastoma risk

To determine whether inherited variations in immune function single-nucleotide polymorphisms (SNPs), genes or pathways affect glioblastoma risk, we analyzed data from recent genome-wide association studies in conjunction with predefined immune function genes and pathways. Gene and pathway analyses were conducted on two independent data sets using 6629 SNPs in 911 genes on 17...

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.