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Search: authors:"Tadashi Yokoi"

6 papers found.
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Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells

We recently established a novel method for generating functional human retinal ganglion cells (RGCs) from human induced pluripotent cells (hiPSCs). Here, we confirmed that RGCs can also be generated from human embryonic stem cells (hESCs). We investigated the usefulness of human RGCs with long axons for assessing the effects of chemical agents, such as the neurotrophic factor...

Molecular Diagnosis of 34 Japanese Families with Leber Congenital Amaurosis Using Targeted Next Generation Sequencing

Science, National Center for Child Health and Development, Tokyo, JapanSachiko Nishina, Tadashi Yokoi, Satoshi Katagiri & Noriyuki AzumaDepartment of Ophthalmology, The Jikei University School of Medicine ... AuthorsSearch for Katsuhiro Hosono in:Nature Research journals • PubMed • Google Scholar Search for Sachiko Nishina in:Nature Research journals • PubMed • Google Scholar Search for Tadashi Yokoi in:Nature

Electroretinographic effects of retinal dragging and retinal folds in eyes with familial exudative vitreoretinopathy

We evaluated the retinal function of retinal dragging (Rdrag) and radial retinal folds (Rfolds) in eyes with familial exudative vitreoretinopathy (FEVR) using full-field electroretinography (ERG). Seventeen eyes of nine patients with FEVR who had Rdrag or Rfolds were retrospectively studied. Eyes were classified into four groups according to the severity of the retinal...

Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells

We generated self-induced retinal ganglion cells (RGCs) with functional axons from human induced pluripotent stem cells. After development of the optic vesicle from the induced stem cell embryoid body in three-dimensional culture, conversion to two-dimensional culture, achieved by supplementation with BDNF, resulted in differentiation of RGCs at a rate of nearly 90% as indicated...

Establishment of Functioning Human Corneal Endothelial Cell Line with High Growth Potential

as positive controls. The skin of dorsal flanks of inoculated mice was surgically opened and the tumorigenic status was examined. Conceived and designed the experiments: Tadashi Yokoi YS Tae Yokoi TK ... AU HN NA. Performed the experiments: Tadashi Yokoi YS Tae Yokoi HM SH MY TK HN NA. Analyzed the data: Tadashi Yokoi YS Tae Yokoi HM SH MY AU HN NA. Contributed reagents/materials/ analysis tools

Two Novel Mutations in the EYS Gene Are Possible Major Causes of Autosomal Recessive Retinitis Pigmentosa in the Japanese Population

Yasuhiko Hirami Hiroshi Nakanishi Shinji Ueno Tadashi Yokoi Akiko Hikoya Taichi Fujita Yang Zhao Sachiko Nishina Jae Pil Shin In Taek Kim Shuichi Yamamoto Noriyuki Azuma Hiroko Terasaki Miho Sato Mineo Kondo