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Plasma cytokine levels and the presence of colorectal cancer

volunteers for their support and participation in this study. Author Contributions Conceptualization: Masaki Yamaguchi. Data curation: Masaki Yamaguchi, Shin Okamura, Taiki Yamaji, Motoki Iwasaki. Funding ... acquisition: Masaki Yamaguchi. Investigation: Masaki Yamaguchi, Shin Okamura, Taiki Yamaji, Motoki Iwasaki. Resources: Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane. Supervision: Shoichiro Tsugane, Vivek

Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1

Fuse, Junichi Sugawara, Atsushi Shimizu, Akimune Fukushima, Asahi Hishida, Norihiro Furusyo, Mariko Naito, Kenji Wakai, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Yoshinori Murakami

Association between plasma concentrations of branched-chain amino acids and adipokines in Japanese adults without diabetes

AffiliationsEpidemiology and Prevention Group, Centre for Public Health Sciences, National Cancer Centre, Tokyo, JapanRyoko Katagiri, Atsushi Goto, Sanjeev Budhathoki, Taiki Yamaji, Motoki Iwasaki & Shoichiro ... journals • PubMed • Google Scholar Search for Taiki Yamaji in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto in:Nature Research journals • PubMed • Google Scholar Search

Association of plasma C-reactive protein level with the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo

Epidemiologic studies have identified a positive association between obesity and colorectal neoplasia. Adiposity induces systemic low-grade inflammation, which is commonly assessed with a sensitive biomarker, C-reactive protein (CRP). To understand the molecular mechanisms of obesity in the etiology of colorectal neoplasia, the present study was conducted in 782 adenoma cases and...

Perceived stress level and risk of cancer incidence in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study

for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji Chuo-ku, Tokyo, 104-0045, JapanEiko Saito, Norie Sawada, Akihisa Hidaka, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Motoki Iwasaki ... journals • PubMed • Google Scholar Search for Taiki Yamaji in:Nature Research journals • PubMed • Google Scholar Search for Atsushi Goto in:Nature Research journals • PubMed • Google Scholar Search for

Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study

Epidemiological and experimental evidence suggest that vitamin D is protective against the risk of colorectal cancer. Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic...

Neighborhood Deprivation and Risk of Cancer Incidence, Mortality and Survival: Results from a Population-Based Cohort Study in Japan

Background In many developed countries, socioeconomic status is associated with cancer incidence and survival. However, research in Japan is sparse. We examined the association between neighborhood deprivation based on the Japanese Deprivation Index and the risk of incidence, mortality and survival from total and major cancers in the Japan Public Health Center-based Prospective...

Dietary arsenic intake and subsequent risk of cancer: the Japan Public Health Center-based (JPHC) Prospective Study

Purpose Arsenic is a known human carcinogen and has been linked to adverse health outcomes, including cancer. However, the effects of arsenic exposure from food on health are still unknown. We researched to examine the association between arsenic exposure from food and incidence of cancer in a Japanese population. Methods We conducted a population-based prospective study in 90...

Association Between Plasma 25-Hydroxyvitamin D and Colorectal Adenoma According to Dietary Calcium Intake and Vitamin D Receptor Polymorphism

: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan (Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Shoichiro Tsugane); and Genetics

Association of Pancreatic Fatty Infiltration With Pancreatic Ductal Adenocarcinoma

histopathological analysis and revision of the manuscript; Taiki Yamaji contributed to the statistical analysis and revision of the manuscript; Michihiro Mutoh contributed to data analysis and revision of the

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols

Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type...

Green tea drinking and subsequent risk of breast cancer in a population to based cohort of Japanese women

Introduction Although many in vitro and animal studies have demonstrated a protective effect of green tea against breast cancer, findings from epidemiological studies have been inconsistent, and whether high green tea intake reduces the risk of breast cancer remains unclear. Methods In this Japan Public Health Center-based Prospective Study, 581 cases of breast cancer were newly...

Use of vitamin supplements and risk of total cancer and cardiovascular disease among the Japanese general population: A population-based survey

Background Despite the popular use of vitamin supplements and several prospective cohort studies investigating their effect on cancer incidence and cardiovascular disease (CVD), scientific data supporting their benefits remain controversial. Inconsistent results may be partly explained by the fact that use of supplements is an inconsistent behavior in individuals. We examined...

Visceral Fat Volume and the Prevalence of Colorectal Adenoma

Few epidemiologic investigations of visceral adiposity and colorectal neoplasms have attempted the direct quantification of visceral fat. The authors measured visceral fat volume among middle-aged and elderly Japanese men and women who underwent colonoscopy and positron emission tomography/computed tomography for cancer screening in Tokyo, Japan, between February 2004 and...

Plasma levels of C-reactive protein and serum amyloid A and gastric cancer in a nested case–control study: Japan Public Health Center-based prospective study

Screening, National Cancer Center , Tokyo 104-0045 , Japan 2 Shizuka Sasazuki , Manami Inoue, Norie Sawada, Motoki Iwasaki, Taichi Shimazu, Taiki Yamaji , Shoichiro Tsugane for the Japan Public Health Center

Dietary Patterns and Colorectal Adenomas in Japanese Men: The Self-Defense Forces Health Study

The role of dietary patterns in colorectal carcinogenesis remains unclear in Asian populations. Using 1999–2002 data, the authors investigated the association between dietary patterns and colorectal adenomas in 1,341 Japanese men who underwent total colonoscopy. Information about diet was obtained using a 74-item food frequency questionnaire prior to the colonoscopy. Three...

Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs

3 4 Motoki Iwasaki 1 4 Taiki Yamaji 1 4 Hideo Kunitoh 0 4 13 Kenji Suzuki 4 8 11 Yoko Shimada 4 Kouya Shiraishi 4 Yoshio Kasuga 4 7 Gerson Shigeaki Hamada 4 6 Koh Furuta 4 5 Koji Tsuta 4 10 Hiromi