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21 papers found.
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A partial agonist for retinoid X receptor mitigates experimental colitis

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is an intractable disease of the gastrointestinal tract. Multiple environmental factors, including food ingredients, have been implicated in the development of these diseases. For example, animal fat-rich diets are predisposing factors for ulcerative colitis, whereas n-3 unsaturated fatty acids...

Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation

journals • PubMed • Google Scholar Search for Takahiro Yamada in:Nature Research journals • PubMed • Google Scholar Search for Takafumi Naito in:Nature Research journals • PubMed • Google Scholar Search

Manual on the proper use of lutetium-177-labeled somatostatin analogue (Lu-177-DOTA-TATE) injectable in radionuclide therapy (2nd ed.)

Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. This guideline was prepared by a study supported by Ministry of Health, Labour, and Welfare, and approved by Japanese Society of Nuclear Medicine. Lu-177-DOTA-TATE treatment in Japan should be carried out according to this guideline...

A prospective study of atopic dermatitis managed without topical corticosteroids for a 6-month period

A prospective study of atopic dermatitis managed without topical corticosteroids for a 6-month period Mototsugu Fukaya,1 Kenji Sato,2 Takahiro Yamada,2 Mitsuko Sato,3 Shigeki Fujisawa,4 Satoko

Alteration of podocyte phenotype in the urine of women with preeclampsia

, Mamoru Morikawa, Takahiro Yamada, Takahiro Koyama & Hisanori Minakami AuthorsSearch for Tianyue Zhai in:Nature Research journals • PubMed • Google ScholarSearch for Itsuko Furuta in:Nature Research ... Mamoru Morikawa in:Nature Research journals • PubMed • Google ScholarSearch for Takahiro Yamada in:Nature Research journals • PubMed • Google ScholarSearch for Takahiro Koyama in:Nature Research journals

MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells

Background In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs). Methods We first used a computational target prediction analysis to identify 6 candidate miRNAs that bind to...

Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124

Derepression of wild-type p53 by suppressing its negative inhibitor iASPP (Inhibitor of apoptosis-stimulating protein of p53) represents a potential therapeutic option for cervical cancer (CC). Here, we reported a novel functional significance of iASPP upregulation in cervical tumorigenesis: iASPP acts as a key promoter of CC cell proliferation, epithelial-mesenchymal transition...

Increased epigenetic alterations at the promoters of transcriptional regulators following inadequate maternal gestational weight gain

Epigenetic modifications are thought to serve as a memory of exposure to in utero environments. However, few human studies have investigated the associations between maternal nutritional conditions during pregnancy and epigenetic alterations in offspring. In this study, we report genome-wide methylation profiles for 33 postpartum placentas from pregnancies of normal and foetal...

Measurement of the Physical Properties during Laparoscopic Surgery Performed on Pigs by Using Forceps with Pressure Sensors

 Masato Ogata,2 Takahiro Yamada,3 and Yoshinobu Kubota1 1Department of Urology, Yokohama City University, Yokohama 236-0004, Japan 2Mitsubishi Precision Co., Ltd., Kamakura 247-8505, Japan 3Graduate School ... Nagasaka, Masato Ogata, and Takahiro Yamada developed the equipment used in this study. Yoshinobu Kubota conceived of the study and helped to draft the paper. All authors read and approved the final paper

Measurement of the Physical Properties during Laparoscopic Surgery Performed on Pigs by Using Forceps with Pressure Sensors

 Masato Ogata,2 Takahiro Yamada,3 and Yoshinobu Kubota1 1Department of Urology, Yokohama City University, Yokohama 236-0004, Japan 2Mitsubishi Precision Co., Ltd., Kamakura 247-8505, Japan 3Graduate School ... Nagasaka, Masato Ogata, and Takahiro Yamada developed the equipment used in this study. Yoshinobu Kubota conceived of the study and helped to draft the paper. All authors read and approved the final paper

Spontaneous Perforation of Pyometra Presenting as Acute Abdomen and Pneumoperitoneum Mimicking Those of Gastrointestinal Origin

; Accepted 20 December 2014 Academic Editor: Steve de Castro Copyright © 2015 Takahiro Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Spontaneous Perforation of Pyometra Presenting as Acute Abdomen and Pneumoperitoneum Mimicking Those of Gastrointestinal Origin

; Accepted 20 December 2014 Academic Editor: Steve de Castro Copyright © 2015 Takahiro Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Interface properties of SiOxNy layer on Si prepared by atmospheric-pressure plasma oxidation-nitridation

SiOxNy films with a low nitrogen concentration (< 4%) have been prepared on Si substrates at 400°C by atmospheric-pressure plasma oxidation-nitridation process using O2 and N2 as gaseous precursors diluted in He. Interface properties of SiOxNy films have been investigated by analyzing high-frequency and quasistatic capacitance-voltage characteristics of metal-oxide-semiconductor...

Effects of campaign for postpartum vaccination on seronegative rate against rubella among Japanese women

Background Japan experienced two rubella outbreaks in the past decade (2004 and 2012 – 2013), resulting in 10 and 20 infants with congenital rubella syndrome (CRS), respectively. This study was performed to determine whether the seronegative rate was lower in multiparous women than in primiparous women in Japan. Methods Hemagglutination inhibition (HI) test results during...

Urinary protein-to-creatinine ratio in pregnant women after dipstick testing: prospective observational study

Background The dipstick test is widely used as a primary screening test for detection of significant proteinuria in pregnancy (SPIP). However, it often shows a false positive test result. This study was performed to determine which pregnant women should be recommended to undergo determination of urinary protein-to-creatinine ratio (mg/mg, P/Cr test) after dipstick test for...

A type of familial cleft of the soft palate maps to 2p24.2–p24.1 or 2p21–p12

Cleft of the soft palate (CSP) and the hard palate are subtypes of cleft palate. Patients with either condition often have difficulty with speech and swallowing. Nonsyndromic, cleft palate isolated has been reported to be associated with several genes, but to our knowledge, there have been no detailed genetic investigations of CSP. We performed a genome-wide linkage analysis...

Present status of neutron fundamental physics at J-PARC

A neutron beamline for the study of fundamental physics has been constructed at the spallation neutron source of the Japan Proton Accelerator Research Complex (J-PARC). In-flight measurement of the neutron lifetime and the development of the transport optics of ultracold neutrons are in progress. The present status of the beamline and these experiments is reported.

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells

Wolfram syndrome, an autosomal recessive disorder associated with diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene encoding an endoplasmic reticulum (ER) membrane protein. Herein, we report that pancreatic islets of wfs1-deficient mice exhibit increases in phosphorylation of RNA-dependent protein kinase-like ER kinase, chaperone gene expressions and...

A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-β1 (TGF-β1) and its signaling pathway

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that is produced in the platelet, bone, placenta, and other tissues. It acts as a growth inhibitor in many types of cells, and also mediates extracellular matrix production and immunosuppression. Mutations in the specific domain of its gene (TGFB1) cause Camurati-Engelmann disease, a bone-sclerosing disorder...

Disruption of the WFS1 gene in mice causes progressive β-cell loss and impaired stimulus–secretion coupling in insulin secretion

Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene. In order to gain insight into the pathophysiology of this disease, we disrupted the wfs1 gene in mice. The mutant mice developed glucose intolerance or overt diabetes due to insufficient insulin secretion in vivo. Islets...