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Search: authors:"Takahiro Yamada"

6 papers found.
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Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation

journals • PubMed • Google Scholar Search for Takahiro Yamada in:Nature Research journals • PubMed • Google Scholar Search for Takafumi Naito in:Nature Research journals • PubMed • Google Scholar Search

Alteration of podocyte phenotype in the urine of women with preeclampsia

, Mamoru Morikawa, Takahiro Yamada, Takahiro Koyama & Hisanori Minakami AuthorsSearch for Tianyue Zhai in:Nature Research journals • PubMed • Google ScholarSearch for Itsuko Furuta in:Nature Research ... Mamoru Morikawa in:Nature Research journals • PubMed • Google ScholarSearch for Takahiro Yamada in:Nature Research journals • PubMed • Google ScholarSearch for Takahiro Koyama in:Nature Research journals

Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124

Derepression of wild-type p53 by suppressing its negative inhibitor iASPP (Inhibitor of apoptosis-stimulating protein of p53) represents a potential therapeutic option for cervical cancer (CC). Here, we reported a novel functional significance of iASPP upregulation in cervical tumorigenesis: iASPP acts as a key promoter of CC cell proliferation, epithelial-mesenchymal transition...

Increased epigenetic alterations at the promoters of transcriptional regulators following inadequate maternal gestational weight gain

Epigenetic modifications are thought to serve as a memory of exposure to in utero environments. However, few human studies have investigated the associations between maternal nutritional conditions during pregnancy and epigenetic alterations in offspring. In this study, we report genome-wide methylation profiles for 33 postpartum placentas from pregnancies of normal and foetal...

A type of familial cleft of the soft palate maps to 2p24.2–p24.1 or 2p21–p12

Cleft of the soft palate (CSP) and the hard palate are subtypes of cleft palate. Patients with either condition often have difficulty with speech and swallowing. Nonsyndromic, cleft palate isolated has been reported to be associated with several genes, but to our knowledge, there have been no detailed genetic investigations of CSP. We performed a genome-wide linkage analysis...

A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-β1 (TGF-β1) and its signaling pathway

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that is produced in the platelet, bone, placenta, and other tissues. It acts as a growth inhibitor in many types of cells, and also mediates extracellular matrix production and immunosuppression. Mutations in the specific domain of its gene (TGFB1) cause Camurati-Engelmann disease, a bone-sclerosing disorder...