Advanced search    

Search: authors:"Takashi Kasai"

8 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients

were conducted using Spearman?s rank correlation coefficient test). (TIF) Author Contributions Conceptualization: Takashi Kasai, Masafumi Morimoto, Tomohiro Chiyonobu, Takahiko Tokuda. Data curation ... : Makiko Shinomoto, Takashi Kasai, Harutsugu Tatebe. Formal analysis: Takashi Kasai, Isao Yokota. Funding acquisition: Takashi Kasai, Takahiko Tokuda. 10 / 13 Investigation: Takashi Kasai, Harutsugu Tatebe

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

There is still a substantial unmet need for less invasive and lower-cost blood-based biomarkers to detect brain Alzheimer’s disease (AD) pathology. This study is aimed to determine whether quantification of plasma tau phosphorylated at threonine 181 (p-tau181) is informative in the diagnosis of AD. We have developed a novel ultrasensitive immunoassay to quantify plasma p-tau181...

Increased levels of plasma total tau in adult Down syndrome

Conceptualization: Takashi Kasai, Masaki Kondo, Masafumi Morimoto, Tomohiro Chiyonobu, Masanori Nakagawa, Takahiko Tokuda. Data curation: Takashi Kasai, Harutsugu Tatebe. Formal analysis: Takashi Kasai. 9 / 12 ... Investigation: Takashi Kasai, Harutsugu Tatebe, Masaki Kondo, Ryotaro Ishii, Takuma Ohmichi, Takahiko Tokuda. Methodology: Takashi Kasai. Project administration: Takashi Kasai. Resources: Takashi Kasai

A retrospective study of amrubicin monotherapy for the treatment of relapsed small cell lung cancer in elderly patients

Purpose Amrubicin is one of the most active chemotherapeutic drugs for small cell lung cancer (SCLC). Previous studies reported its effectiveness and severe hematological toxicity. However, the efficacy of amrubicin monotherapy in elderly patients with SCLC has not been described. The objective of this study was to investigate the feasibility of amrubicin monotherapy in elderly...

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

Intravenous immunoglobulin (IVIg) has been a candidate as a potential anti-amyloid immunotherapy for Alzheimer disease (AD) because it contains anti-amyloid β (Aβ) antibodies. Although several studies with IVIg in AD have been published, changing levels of Aβ efflux from the brain, or disaggregation of Aβ species induced by immunotherapy, have not been properly investigated. Here...

Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy

The COQ2 gene encodes an essential enzyme for biogenesis, coenzyme Q10 (CoQ10). Recessive mutations in this gene have recently been identified in families with multiple system atrophy (MSA). Moreover, specific heterozygous variants in the COQ2 gene have also been reported to confer susceptibility to sporadic MSA in Japanese cohorts. These findings have suggested the potential...

Decrease in Plasma Levels of α-Synuclein Is Evident in Patients with Parkinson’s Disease after Elimination of Heterophilic Antibody Interference

There is substantial biochemical, pathological, and genetic evidence that α-synuclein (A-syn) is a principal molecule in the pathogenesis of Parkinson disease (PD). We previously reported that total A-syn levels in cerebrospinal fluid (CSF), measured with the specific enzyme-linked immunosorbent assay (ELISA) developed by ourselves, were decreased in patients with PD, and...

Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study

Ozaki 0 Daisuke Matsui 0 Isao Watanabe 0 Fumitaro Miyatani 0 Masaki Kondo Aiko Tamura Takashi Kasai Yoichi Ohshima Tomokatsu Yoshida Takahiko Tokuda Ikuko Mizuta Shigeto Mizuno Kei Yamada Kazuo Takeda